Bifurcations in planar, quadratic mass-action networks with few reactions and low molecularity.

Murad Banaji, Bal��zs Boros, Josef Hofbauer
Author Information
  1. Murad Banaji: Mathematical Institute, University of Oxford, Oxford, UK.
  2. Bal��zs Boros: Department of Mathematics, University of Vienna, Vienna, Austria.
  3. Josef Hofbauer: Department of Mathematics, University of Vienna, Vienna, Austria.

Abstract

In this paper we study bifurcations in mass-action networks with two chemical species and reactant complexes of molecularity no more than two. We refer to these as planar, quadratic networks as they give rise to (at most) quadratic differential equations on the nonnegative quadrant of the plane. Our aim is to study bifurcations in networks in this class with the fewest possible reactions, and the lowest possible product molecularity. We fully characterise generic bifurcations of positive equilibria in such networks with up to four reactions, and product molecularity no higher than three. In these networks we find fold, Andronov-Hopf, Bogdanov-Takens and Bautin bifurcations, and prove the non-occurrence of any other generic bifurcations of positive equilibria. In addition, we present a number of results which go beyond planar, quadratic networks. For example, we show that mass-action networks without conservation laws admit no bifurcations of codimension greater than , where is the number of reactions; we fully characterise quadratic, rank-one mass-action networks admitting fold bifurcations; and we write down some necessary conditions for Andronov-Hopf and cusp bifurcations in mass-action networks. Finally, we draw connections with a number of previous results in the literature on nontrivial dynamics, bifurcations, and inheritance in mass-action networks.

Keywords

References

  1. BMC Syst Biol. 2009 Sep 08;3:90 [PMID: 19737387]
  2. Bull Math Biol. 2021 May 1;83(6):64 [PMID: 33932170]
  3. Stud Appl Math. 2024 Jan;152(1):249-278 [PMID: 38516583]

Grants

  1. P 32532/Austrian Science Fund FWF

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