- Dave T F Kuo: Graduate Institute of Environmental Engineering, National Taiwan University, Taipei City, Taiwan. Electronic address: davekuo@ntu.edu.tw.
Ingestive uptake is critical for understanding the accumulation and trophic transfer of chemicals and synthesized particles in general. This study explored the contribution of ingestion in the bioaccumulation of chemicals focusing on worms. Novel theory and equations were developed to derive fractional ingestive contribution, f, from a broad range of dietary uptake and accumulation studies, and to build a small dataset of f (n = 43) from relevant toxicokinetic and bioaccumulation measurements. Worm f could be fitted to log K-based sigmoidal models with small errors (RSE < 0.15, RMSE<0.15). The basis and limitations of the applied f equations were elaborated. These included the assumption that aqueous-based and dietary-based elimination rate constants (k and k) may be statistically equivalent, as demonstrated using fish and worm data. Bioaccumulation and toxicokinetic parameters obtained at under-exposed conditions can also result in non-sensical, negative f. The developed f theory suggested a novel way to model bioaccumulation in the presence of aqueous and solid sources, and the potential to consolidate bioaccumulation data in their variant forms and definitions for assessment, modeling, and benchmarking purposes. While the presented f-log K dependence remained to be explored in other species, the importance of ingestive uptake for high-log K chemicals questioned the validity of characterizing and regulating bioaccumulation potential of hydrophobic organics - for which dietary uptake matters - using aqueous-only bioconcentration factor (BCF). This question, along with other less important ones, is yet to be explored in future works.