Evaluating Lichen Sclerosus in Phimosis: Insights From a Multidisciplinary Retrospective Study.

Stefano Bighetti, Stefano Mancon, Nazareno Suardi, Piergiacomo Calzavara-Pinton, Vincenzo Maione, Mariachiara Arisi, Giovanni Lughezzani, Nicola Zerbinati, Iacopo Ghini, Luca Bettolini
Author Information
  1. Stefano Bighetti: Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. ORCID
  2. Stefano Mancon: Department of Biomedical Sciences, Humanitas University, Milan, Italy. ORCID
  3. Nazareno Suardi: Urology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. ORCID
  4. Piergiacomo Calzavara-Pinton: Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. ORCID
  5. Vincenzo Maione: Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. ORCID
  6. Mariachiara Arisi: Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. ORCID
  7. Giovanni Lughezzani: Department of Biomedical Sciences, Humanitas University, Milan, Italy. ORCID
  8. Nicola Zerbinati: Dermatology Unit, Department of Medicine and Surgery, University of Insubria, ASST Dei Sette Laghi, Varese, Italy. ORCID
  9. Iacopo Ghini: Pathology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.
  10. Luca Bettolini: Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. ORCID

Abstract

OBJECTIVES: This study aimed to evaluate the prevalence of lichen sclerosus (LS) in male patients undergoing circumcision for phimosis, emphasising the significance of a multidisciplinary approach in the early diagnosis and management of this condition.
METHODS: A retrospective analysis was performed on 841 male patients who underwent circumcision at a high-volume medical centre between 2001 and 2023. Data were collected on clinical diagnoses made by both dermatologists and urologists, along with the corresponding histological findings. Logistic regression models were utilised to assess diagnostic accuracy and the relationship between clinical suspicion and histological confirmation.
RESULTS: Histological confirmation of LS was identified in 30.6% of the cases. Dermatologists demonstrated a diagnostic accuracy of 81.8%, whereas urologists showed an accuracy of 46.1%. The evaluations conducted by dermatologists exhibited a significant correlation with histological confirmation of LS (odds ratio 4.81; 95% confidence interval: 1.96-11.80; p���=���0.001).
CONCLUSIONS: This study elucidates the differences in diagnostic accuracy between dermatologists and urologists in identifying LS in patients undergoing circumcision for phimosis, highlighting the necessity of a multidisciplinary approach to improve the diagnostic process. Furthermore, the epidemiological data obtained from this research offer valuable insights into the prevalence of LS and the associated diagnostic challenges within a substantial patient cohort.

Keywords

References

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MeSH Term

Humans
Male
Phimosis
Retrospective Studies
Circumcision, Male
Lichen Sclerosus et Atrophicus
Adult
Adolescent
Young Adult
Middle Aged
Child
Prevalence
Child, Preschool
Aged

Word Cloud

Created with Highcharts 10.0.0LSdiagnosticcircumcisionaccuracypatientsphimosisdermatologistsurologistshistologicalconfirmationstudyprevalencelichensclerosusmaleundergoingmultidisciplinaryapproachclinical81OBJECTIVES:aimedevaluateemphasisingsignificanceearlydiagnosismanagementconditionMETHODS:retrospectiveanalysisperformed841underwenthigh-volumemedicalcentre20012023DatacollecteddiagnosesmadealongcorrespondingfindingsLogisticregressionmodelsutilisedassessrelationshipsuspicionRESULTS:Histologicalidentified306%casesDermatologistsdemonstrated8%whereasshowed461%evaluationsconductedexhibitedsignificantcorrelationoddsratio495%confidenceinterval:196-1180p���=���0001CONCLUSIONS:elucidatesdifferencesidentifyinghighlightingnecessityimproveprocessFurthermoreepidemiologicaldataobtainedresearchoffervaluableinsightsassociatedchallengeswithinsubstantialpatientcohortEvaluatingLichenSclerosusPhimosis:InsightsMultidisciplinaryRetrospectiveStudydermatologicalconsultationpreputialpathologies

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