2-ethylhexyl 4-methoxycinnamate (EHMC), a UV filter commonly used in sunscreen products, is also an emerging environmental pollutant that interferes with the structure and function of bovine serum albumin (BSA). A study was conducted on the interaction between EHMC and BSA when they coexist and are encapsulated within ��-cyclodextrin (��-CD). Multiple spectra demonstrate, both qualitatively and quantitatively, that ��-CD coexistence and encapsulation weaken the interaction between EHMC and BSA, resulting in a more difficult binding process between the two and inhibiting EHMC-induced conformational changes in BSA. Once encapsulated by ��-CD, the inclusion complex (IC) was weakly bound to BSA (=(7.63��������0.01)��10 M), and it had no significant impact on BSA's structure. Despite this, ��-CD did not significantly alter EHMC's UV shielding ability.
