Altered controllability of functional brain networks in obsessive-compulsive disorder.
Ya Tian, Wenqing Shi, Qiuying Tao, Huiting Yang, Huirong Guo, Baohong Wen, Zijun Liu, Jin Sun, Huafu Chen, Yong Zhang, Jingliang Cheng, Shaoqiang Han
Author Information
Ya Tian: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Wenqing Shi: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Qiuying Tao: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Huiting Yang: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Huirong Guo: Department of Psychiatry, First Affiliated Hospital of Zhengzhou University, China.
Baohong Wen: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Zijun Liu: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Jin Sun: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China.
Huafu Chen: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, China.
Yong Zhang: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China. Electronic address: zzuzhangyong2013@163.com.
Jingliang Cheng: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China. Electronic address: fccchengjl@zzu.edu.cn.
Shaoqiang Han: Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, China; Zhengzhou Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging, China; Henan Engineering Technology Research Center for Detection and Application of Brain Function, China; Henan Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment, China; Henan Key Laboratory of Imaging Intelligence Research, China; Henan Engineering Research Center of Brain Function Development and Application, China. Electronic address: shaoqianghan@163.com.
Disruptions in the dynamic transitions between brain states have been implicated in cognitive, emotional, and behavioral dysregulations across various mental disorders. However, the irregularities in dynamic brain state transitions associated with obsessive-compulsive disorder (OCD) remain unclear. The present study included 99 patients with OCD and 104 matched healthy controls (HCs) to investigate alterations in dynamic brain state transitions by using network control theory. Functional controllability metrics were computed and compared between the OCD group and HCs. Additionally, abnormal functional connectivity (FC) between the brain regions with statistical differences in functional controllability and remaining brain regions were assessed. Patients with OCD exhibited significantly decreased average controllability (AC) and increased modal controllability (MC) in the right parahippocampal gyrus (PHG), compared to the HCs. Further analysis showed significantly decreased FC between the right PHG and bilateral superior temporal gyrus and occipital gyrus, left postcentral gyrus, and right cingulate gyrus in OCD patients. The results suggest aberrant brain state transitions in OCD patients, alongside widespread disruptions within the brain functional connectome. This study highlights the critical role of altered functional controllability within the right PHG in the neuropathological mechanisms of OCD, providing novel insights into the pathogenesis of OCD.
