Pooled prevalence and multilevel determinants of stillbirths in sub-Saharan African countries: implications for achieving sustainable development goal.

Bewuketu Terefe, Mahlet Moges Jembere, Nega Nigussie Abrha, Dejen Kahsay Asgedom, Solomon Keflie Assefa, Nega Tezera Assimamaw
Author Information
  1. Bewuketu Terefe: Department of Community Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. woldeabwomariam@gmail.com. ORCID
  2. Mahlet Moges Jembere: Department of Emergency, and Critical Care Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
  3. Nega Nigussie Abrha: Department of Emergency, and Critical Care Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
  4. Dejen Kahsay Asgedom: Department of Public Health, College of Medicine and Health Sciences, Samara University, Afar, Ethiopia.
  5. Solomon Keflie Assefa: Pawe Health Science College, Pawe, Northwest Ethiopia, Ethiopia.
  6. Nega Tezera Assimamaw: Department of Pediatrics, and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Abstract

BACKGROUND: Despite being included in the Millennium Development Goals (MDGs) and now the Sustainable Development Goals (SDGs), stillbirths remain overlooked with limited regional research, highlighting an ongoing gap in addressing this issue. However, a staggering 2 million stillbirths occur each year, equivalent to one every 16 s. Furthermore, approximately 98% of these stillbirths take place in developing countries, particularly in sub-Saharan Africa (SSA). In light of these statistics and the need to address the lack of data, methodological approaches, and population gaps, this study aims to assess the prevalence and determinants of stillbirths in SSA from 2016 to 2023, aligning with the SDGs.
METHODS: This study used data from the Demographic and Health Survey (DHS) conducted in SSA. The analysis included a weighted sample of 212,194 pregnancies of at least 28 weeks' gestation collected from 2016 to 2023, using R-4.4.0 software. Descriptive data, such as frequencies, were performed. Stillbirth prevalence was visualized using a forest plot. A multilevel modeling analysis was used by considering individual-level factors and community level factors. The multilevel model was employed to account for clustering within countries and allow for the examination of both fixed and random effects that influence stillbirths. For the multivariable analysis, variables with a p value ≤ 0.2 in the bivariate analysis were considered. The Adjusted Odds Ratio (AOR) with a 95% Confidence Interval (CI) and a p value < 0.05 were reported to indicate the statistical significance and the degree of association in the final model.
RESULTS: The pooled prevalence of stillbirths was found to be 1.54% per 100 [95% CI 1.19-2.01]. Factors positively associated with stillbirths in SSA included maternal age (25-34 years, 35-49 years), marital status (married, divorced or widowed), antenatal care visits, age at first birth (before age 20), short birth intervals, long birth intervals, birth order (second or third), residence in rural areas, country income level (lower middle income), and low literacy rate. Factors negatively associated with stillbirth mortality included maternal education (primary education, secondary or higher education), wealth index (higher economic status), access to mass media, access to improved drinking water, distance to health facilities, and country income level (upper middle income).
CONCLUSIONS: Stillbirth rates fall significantly short of achieving Every Newborn Action Plan target by 2030 in SSA. The analysis of factors that affect stillbirth mortality reveals important connections. It is essential to improve maternal education, economic status, and healthcare infrastructure to decrease stillbirth rates and enhance the health outcomes of mothers and children in the region. To effectively address these risks, efforts should concentrate on increasing access to antenatal care, raising awareness, and improving socio-economic conditions. By improving access to healthcare and education, these disparities could potentially lead to a decrease in stillbirth rates in the region.

Keywords

References

  1. BJOG. 2007 Sep;114(9):1079-87 [PMID: 17617195]
  2. Glob Pediatr Health. 2021 May 15;8:2333794X211015524 [PMID: 34036123]
  3. BJOG. 2011 Dec;118(13):1636-45 [PMID: 21933338]
  4. Glob Health Action. 2021 Jan 1;14(1):1859823 [PMID: 33446087]
  5. PLoS One. 2022 Dec 13;17(12):e0276220 [PMID: 36512623]
  6. Rev Lat Am Enfermagem. 2013 Sep-Oct;21(5):1062-70 [PMID: 24142214]
  7. BMC Pregnancy Childbirth. 2023 Dec 4;23(1):835 [PMID: 38049743]
  8. Acta Obstet Gynecol Scand. 2024 Jan;103(1):111-120 [PMID: 37891707]
  9. BMC Pregnancy Childbirth. 2009 May 07;9 Suppl 1:S3 [PMID: 19426466]
  10. Reprod Health. 2020 Nov 30;17(Suppl 2):146 [PMID: 33256783]
  11. Lancet. 2012 Jun 9;379(9832):2151-61 [PMID: 22579125]
  12. Lancet Reg Health Southeast Asia. 2022 Dec 06;9:100116 [PMID: 37383033]
  13. Lancet Glob Health. 2016 Feb;4(2):e98-e108 [PMID: 26795602]
  14. Future Child. 1999 Spring-Summer;9(1):44-65, 190-1 [PMID: 10414010]
  15. Reprod Health. 2016 Aug 31;13:103 [PMID: 27581467]
  16. BMC Pregnancy Childbirth. 2014 Mar 03;14:94 [PMID: 24589139]
  17. BMC Public Health. 2018 Jul 18;18(1):888 [PMID: 30021557]
  18. World Health Stat Q. 1993;46(4):222-6 [PMID: 8017081]
  19. BMC Pregnancy Childbirth. 2020 Jul 29;20(1):432 [PMID: 32727403]
  20. BMC Pregnancy Childbirth. 2013 Jan 16;13:12 [PMID: 23324309]
  21. Am J Epidemiol. 2005 Jan 1;161(1):81-8 [PMID: 15615918]
  22. BMJ Glob Health. 2021 Oct;6(10): [PMID: 34615663]
  23. N Engl J Med. 2004 Feb 19;350(8):777-85 [PMID: 14973215]
  24. Lancet. 2016 Feb 6;387(10018):587-603 [PMID: 26794078]
  25. PLOS Glob Public Health. 2023 Jan 26;3(1):e0001468 [PMID: 36963030]
  26. PLoS Med. 2012 Jan;9(1):e1001162 [PMID: 22291577]
  27. Int J Gynaecol Obstet. 2018 Apr;141(1):113-119 [PMID: 29318613]
  28. Acta Obstet Gynecol Scand. 2016 Feb;95(2):135-43 [PMID: 26577070]
  29. BMC Pregnancy Childbirth. 2021 Jun 2;21(1):414 [PMID: 34078299]
  30. BMC Pregnancy Childbirth. 2019 Dec 4;19(1):470 [PMID: 31801488]
  31. Int J Gynaecol Obstet. 2011 May;113(2):91-5 [PMID: 21349517]
  32. Trop Med Int Health. 2017 Jan;22(1):63-73 [PMID: 27910181]
  33. Pan Afr Med J. 2020 Oct 02;37:114 [PMID: 33425147]
  34. JAMA. 2006 Apr 19;295(15):1809-23 [PMID: 16622143]
  35. PLoS One. 2019 Aug 23;14(8):e0221503 [PMID: 31442258]
  36. Paediatr Perinat Epidemiol. 2013 Mar;27(2):158-64 [PMID: 23374060]
  37. PLoS One. 2021 Jan 7;16(1):e0245297 [PMID: 33411850]
  38. Glob Health Action. 2017;10(1):1270536 [PMID: 28156197]
  39. Early Hum Dev. 1990 Jun;22(3):157-69 [PMID: 2397715]
  40. Arch Med Res. 2002 Jul-Aug;33(4):351-5 [PMID: 12234524]
  41. BMC Pregnancy Childbirth. 2022 Jan 4;22(1):11 [PMID: 34983439]
  42. BMJ. 2015 Jun 24;350:h3080 [PMID: 26109551]
  43. BMC Pregnancy Childbirth. 2015 Jul 05;15:146 [PMID: 26143456]
  44. J Clin Diagn Res. 2013 Dec;7(12):2796-699 [PMID: 24551640]
  45. J Pregnancy. 2020 Sep 22;2020:6859157 [PMID: 33029401]
  46. Obstet Gynecol. 2011 May;117(5):1151-1159 [PMID: 21508755]
  47. PLoS Med. 2017 Aug 1;14(8):e1002364 [PMID: 28763442]
  48. Am J Obstet Gynecol. 2006 Sep;195(3):764-70 [PMID: 16949411]

MeSH Term

Stillbirth
Humans
Africa South of the Sahara
Prevalence
Female
Sustainable Development
Adult
Pregnancy
Young Adult
Middle Aged
Adolescent
Health Surveys

Word Cloud

Created with Highcharts 10.0.0stillbirthsSSAanalysiseducationincludedprevalencebirthincomeaccessdataStillbirthmultilevelfactorslevelmaternalagestatusstillbirthDevelopmentGoalsSustainableSDGs2countriessub-SaharanAfricaaddressstudydeterminants20162023usedusingmodelingmodelpCI1FactorsassociatedantenatalcareshortintervalscountrymiddlemortalityhighereconomichealthachievinghealthcaredecreaseregionimprovingdevelopmentgoalBACKGROUND:DespiteMillenniumMDGsnowremainoverlookedlimitedregionalresearchhighlightingongoinggapaddressingissueHoweverstaggeringmillionoccuryearequivalentoneevery16 sFurthermoreapproximately98%takeplacedevelopingparticularlylightstatisticsneedlackmethodologicalapproachespopulationgapsaimsassessaligningMETHODS:DemographicHealthSurveyDHSconductedweightedsample212194pregnanciesof atleast28 weeks'gestationcollected fromR-440softwareDescriptivefrequenciesperformedvisualizedforestplotconsideringindividual-levelcommunityemployedto accountclusteringwithinallowexaminationfixedrandomeffectsinfluencemultivariablevariablesvalue ≤ 0bivariateconsideredAdjustedOddsRatioAOR95%ConfidenceIntervalvalue < 005reportedindicatestatisticalsignificancedegreeassociationfinalRESULTS:pooledfound54%per100[95%19-201]positively25-34 years35-49 yearsmaritalmarrieddivorcedwidowedvisitsfirst20longordersecondthirdresidenceruralareaslowerlowliteracyratenegativelyprimarysecondarywealthindexmassmediaimproveddrinkingwaterdistancefacilitiesupperCONCLUSIONS:rates fallsignificantlyEveryNewbornActionPlantarget2030affectrevealsimportantconnectionsessentialimproveinfrastructurestillbirth ratesenhanceoutcomesmotherschildreneffectivelyriskseffortsconcentrateincreasingraisingawarenesssocio-economicconditionsdisparitiespotentiallyleadratesPooledAfricancountries:implicationssustainableDeterminantsMultilevelSub-Saharan

Similar Articles

Cited By