Prevalence of Culture-Confirmed Pulmonary Tuberculosis Requiring ICU Admission and the Trend in Prevalence Before and During the COVID-19 Pandemic in a Tertiary Academic Medical Center in Kuala Lumpur, Malaysia: A 7-Year Retrospective Cohort Study.
Nadia Atiya, M Shahnaz Hasan, Chee Kuan Wong, Azwani Abdullah, Khai Siang Lau, Eu Gene Cheah, Yady Zikry, Ying Xi Ngu, Yik Pheng Teo, Koo Koon Lim
Author Information
Nadia Atiya: Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. ORCID
M Shahnaz Hasan: Department of Anaesthesiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Chee Kuan Wong: Division of Respiratory Medicine, Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Azwani Abdullah: Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Khai Siang Lau: Department of Medical Microbiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia. ORCID
Eu Gene Cheah: Department of Medical Microbiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
Yady Zikry: Department of Medical Microbiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
Ying Xi Ngu: Department of Medical Microbiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
Yik Pheng Teo: Department of Medical Microbiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
Koo Koon Lim: Department of Medical Microbiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia.
There are limited data on pulmonary tuberculosis (PTB) requiring intensive care unit (ICU) admission despite its high mortality rate. The objectives of our study were to determine the prevalence of culture-confirmed PTB requiring ICU admission and the trend in prevalence before and during the COVID-19 pandemic. A retrospective cohort study was conducted on all patients aged ���18 years with culture-confirmed PTB requiring ICU admission in a Malaysian tertiary academic medical center from 2015 to 2021. The linear-by-linear association test was performed to determine if the trend in prevalence was significant. The overall prevalence of culture-confirmed PTB requiring ICU admission was 8.0% (139/1736). Between 2015 and 2021, the prevalence increased by 5.8% from 1.6% (5/312) to 7.4% (16/215) ( < .001). This study demonstrated an overall low but increasing trend in the prevalence of culture-confirmed PTB requiring ICU admission. Disruption in TB services during the COVID-19 pandemic may have impacted the prevalence trend.
