Diagnostic platforms for snakebite: Current approaches and challenges in medically important species.
Nairo Brilhante-da-Silva, Sibele Andrade Roberto, Nidiane Dantas Reis Prado, Laura Rosilene Soares-de-Souza, Anna Carolina Machado Marinho, Carla Freire Celedonio Fernandes, Soraya Dos Santos Pereira
Author Information
Nairo Brilhante-da-Silva: Laborat��rio de Engenharia de Anticorpos, Funda����o Oswaldo Cruz Rond��nia, FIOCRUZ RO, 76812-245, Porto Velho, RO, Brazil.
Sibele Andrade Roberto: Laborat��rio de Engenharia de Anticorpos, Funda����o Oswaldo Cruz Rond��nia, FIOCRUZ RO, 76812-245, Porto Velho, RO, Brazil; Programa de P��s-gradua����o em Biologia Experimental, PPG-BIOEXP, Universidade Federal de Rond��nia, UNIR, Porto Velho, Rond��nia, Brazil.
Nidiane Dantas Reis Prado: Laborat��rio de Engenharia de Anticorpos, Funda����o Oswaldo Cruz Rond��nia, FIOCRUZ RO, 76812-245, Porto Velho, RO, Brazil.
Laura Rosilene Soares-de-Souza: Laborat��rio de Engenharia de Anticorpos, Funda����o Oswaldo Cruz Rond��nia, FIOCRUZ RO, 76812-245, Porto Velho, RO, Brazil.
Anna Carolina Machado Marinho: Laborat��rio Multiusu��rio de Pesquisa e Desenvolvimento, Funda����o Oswaldo Cruz Cear��, FIOCRUZ CE, 61760-000, Eusebio, CE, Brazil.
Carla Freire Celedonio Fernandes: Laborat��rio Multiusu��rio de Pesquisa e Desenvolvimento, Funda����o Oswaldo Cruz Cear��, FIOCRUZ CE, 61760-000, Eusebio, CE, Brazil.
Soraya Dos Santos Pereira: Laborat��rio de Engenharia de Anticorpos, Funda����o Oswaldo Cruz Rond��nia, FIOCRUZ RO, 76812-245, Porto Velho, RO, Brazil; Programa de P��s-gradua����o em Biologia Experimental, PPG-BIOEXP, Universidade Federal de Rond��nia, UNIR, Porto Velho, Rond��nia, Brazil. Electronic address: soraya.santos@fiocruz.br.
Diagnosing snakebite envenoming is a critical aspect of managing this life-threatening condition. Achieving the impacts and clinical applications of the diagnosis of snakebites is important to help clarify the challenges faced in identifying venomous snakebites and implementing effective treatment strategies. The complexity of the envenomation requires a comprehensive diagnostic approach, considering both clinical symptoms and laboratory findings. Despite advances in diagnostic technologies, the lack of standardized tools represents a significant obstacle to obtaining accurate and timely assessments. This paper analyzes the state-of-the-art snakebite diagnosis, emphasizing the need for methodologies for differential diagnosis of snakebites. Furthermore, it investigates the far-reaching consequences of late or incorrect diagnoses, emphasizing their role in the potential development of serious morbidity and even mortality. The discussion extends to the global health burden caused by snakebite envenoming, emphasizing the importance of personalized diagnostic methods in regions with diverse snake species. Furthermore, the review explores recent advances in the global scale diagnosis of snakebite venom. The clinical applications of these innovations are explored, highlighting their potential to revolutionize snakebite management in resource-limited settings. By addressing the multifaceted challenges in snakebite diagnosis, this summary contributes to ongoing efforts to mitigate the global impact of snakebite envenoming by highlighting the critical need for collaborative research, standardization, and accessibility of diagnostic tools.