Xiaoyao Xiong: State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China lywang@mail.buct.edu.cn guoc@mail.buct.edu.cn.
Sijia Li: State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China lywang@mail.buct.edu.cn guoc@mail.buct.edu.cn.
Yumin Li: State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China lywang@mail.buct.edu.cn guoc@mail.buct.edu.cn.
Suying Xu: State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China lywang@mail.buct.edu.cn guoc@mail.buct.edu.cn. ORCID
Chang Guo: State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China lywang@mail.buct.edu.cn guoc@mail.buct.edu.cn.
Leyu Wang: State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology Beijing 100029 China lywang@mail.buct.edu.cn guoc@mail.buct.edu.cn. ORCID
Redox processes are indispensable for physiology, and dysregulated redox balance is critical in various metabolic diseases. The development of imaging diagnosis tools for real-time monitoring of the redox state is of great importance yet highly challenging. Here, we designed trifluoromethyl (-CF) grafted selenide polymer nanoprobes for reversible redox sensing . Based on the reversible shift of the F-nuclear magnetic resonance (NMR) peak between oxidation and reduction states of the nanoprobes exposed to different redox species, the F-magnetic resonance imaging (MRI) signal ratio of /( + ) was successfully applied to monitor the redox state in a tumor. These nanoprobes demonstrated good biocompatibility and great potential for exploring physiological and pathological redox processes in deep tissues. We envision that this work will enable the rational design of F-MRI nanoprobes with excellent redox response for the real-time monitoring of the redox state at the lesion location.
