Effects of carbohydrate reduced diet associated with strength training on clinical signs of women with polycystic ovary syndrome: Randomized clinical trial.
Laura Colonetti, Maria Laura Rodrigues Uggioni, Gabriele da Silveira Prestes, Luana Stangherlin, João Carlos Denoni Junior, Rafael Moura, Erica da Silva Sipriano, Kristian Madeira, Hemmylly Silveira Cardoso, Sarah Dagostin Ferraz, Mateus Marcelo Baptista, Antonio Jose Grande, Luciane Bisognin Ceretta, Maria Inês da Rosa, Tamy Colonetti
Author Information
Laura Colonetti: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Maria Laura Rodrigues Uggioni: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Gabriele da Silveira Prestes: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Luana Stangherlin: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
João Carlos Denoni Junior: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil. Electronic address: joaocdenonii@gmail.com.
Rafael Moura: Postgraduate Program in Collective Health, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Erica da Silva Sipriano: Quantitative Methods Research Group, Laboratory of Applied Research in Computing and Quantitative Methods, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Kristian Madeira: Quantitative Methods Research Group, Laboratory of Applied Research in Computing and Quantitative Methods, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Hemmylly Silveira Cardoso: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Sarah Dagostin Ferraz: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Mateus Marcelo Baptista: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Antonio Jose Grande: Laboratory of Evidence-Based Practice, State University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Luciane Bisognin Ceretta: Postgraduate Program in Collective Health, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Maria Inês da Rosa: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
Tamy Colonetti: Epidemiology Group, Laboratory of Biomedicine Translational, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil.
OBJECTIVE: To evaluate the effects of a low-carbohydrate diet associated with strength training on the clinical signs of polycystic ovary syndrome (PCOS). RESEARCH METHODS AND PROCEDURES: A randomized clinical trial was carried out including 29 women over 18 years old diagnosed with PCOS, randomized into two groups, with follow-up for 12 weeks: the low-carbohydrate diet group associated with strength exercise (LCDE); and the standard diet group associated with strength exercise (SDE). We evaluated manifestations of acne, hirsutism by the Ferriman-Gallwey scale and alopecia by the Ludwig-Savin scale, and assessed laboratory tests for total and free testosterone, dehydroepiandrosterone, follicle-stimulating hormone, and luteinizing hormone. The collected data were analyzed using IBM-SPSS software version 21. RESULTS: The study showed statistically significant differences in the hormonal levels of dehydroepiandrosterone (P = 0.045), luteinizing hormone (P = 0.017) and follicle-stimulating hormone (P = 0.014) when comparing the LCDE and SDE groups. CONCLUSIONS: the intervention used can promote an improvement in the clinical presentation of PCOS, especially in hormonal parameters. The clinical trial was registered on the REBEC platform (Brazilian Registry of Clinical Trials) under number RBR4wjqxcv (Carbohydrate Reduction and Exercise in Women with PCOS) and is available on the website: https://ensaiosclinicos.gov.br/rg/RBR-4wjqxcv.
