Current role of extracorporeal membrane oxygenation for the management of trauma patients: Indications and results.

Mohammed Abdulrahman, Maryam Makki, Malak Bentaleb, Dana Khamis Altamimi, Marcelo Af Ribeiro Junior
Author Information
  1. Mohammed Abdulrahman: Department of Surgery, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi 11001, United Arab Emirates.
  2. Maryam Makki: Department of Surgery, Division of Trauma, Critical Care and Acute Care Surgery, Sheikh Shakhbout Medical City, Abu Dhabi 11001, United Arab Emirates.
  3. Malak Bentaleb: Department of Surgery, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi 11001, United Arab Emirates.
  4. Dana Khamis Altamimi: Department of Surgery, Sheikh Shakhbout Medical City, Abu Dhabi 91888, AD, United Arab Emirates.
  5. Marcelo Af Ribeiro Junior: Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, United States. drmribeiro@gmail.com.

Abstract

Extracorporeal membrane oxygenation (ECMO) has emerged as a vital circulatory life support measure for patients with critical cardiac or pulmonary conditions unresponsive to conventional therapies. ECMO allows blood to be extracted from a patient and introduced to a machine that oxygenates blood and removes carbon dioxide. This blood is then reintroduced into the patient's circulatory system. This process makes ECMO essential for treating various medical conditions, both as a standalone therapy and as adjuvant therapy. Veno-venous (VV) ECMO primarily supports respiratory function and indicates respiratory distress. Simultaneously, veno-arterial (VA) ECMO provides hemodynamic and respiratory support and is suitable for cardiac-related complications. This study reviews recent literature to elucidate the evolving role of ECMO in trauma care, considering its procedural intricacies, indications, contraindications, and associated complications. Notably, the use of ECMO in trauma patients, particularly for acute respiratory distress syndrome and cardiogenic shock, has demonstrated promising outcomes despite challenges such as anticoagulation management and complications such as acute kidney injury, bleeding, thrombosis, and hemolysis. Some studies have shown that VV ECMO was associated with significantly higher survival rates than conventional mechanical ventilation, whereas other studies have reported that VA ECMO was associated with lower survival rates than VV ECMO. ECMO plays a critical role in managing trauma patients, particularly those with acute respiratory failure. Further research is necessary to explore the full potential of ECMO in trauma care. Clinicians should have a clear understanding of the indications and contraindications for the use of ECMO to maximize its benefits in treating trauma patients.

Keywords

References

  1. Curr Cardiol Rev. 2021;17(4):e290421188337 [PMID: 33238845]
  2. Cureus. 2019 Aug 11;11(8):e5365 [PMID: 31423406]
  3. Circulation. 2019 Dec 10;140(24):2019-2037 [PMID: 31815538]
  4. Ann Card Anaesth. 2016 Jan-Mar;19(1):97-111 [PMID: 26750681]
  5. Curr Opin Crit Care. 2019 Aug;25(4):397-402 [PMID: 31116109]
  6. Korean Circ J. 2019 Aug;49(8):657-677 [PMID: 31364329]
  7. Anaesth Crit Care Pain Med. 2018 Jun;37(3):259-268 [PMID: 29033360]
  8. BMC Anesthesiol. 2014 Aug 06;14:65 [PMID: 25110462]
  9. Transfus Med Rev. 2015 Apr;29(2):90-101 [PMID: 25595476]
  10. Am J Respir Crit Care Med. 2021 Jul 1;204(1):34-43 [PMID: 33823118]
  11. Cureus. 2022 Jul 11;14(7):e26735 [PMID: 35967165]
  12. Front Med Technol. 2022 Jun 21;4:909990 [PMID: 35800469]
  13. ASAIO J. 2021 Jun 1;67(6):601-610 [PMID: 33965970]
  14. J Card Surg. 2016 Apr;31(4):248-52 [PMID: 26842109]
  15. J Trauma Acute Care Surg. 2024 Feb 1;96(2):186-194 [PMID: 37843631]
  16. Pulm Ther. 2023 Mar;9(1):109-126 [PMID: 36670314]
  17. Membranes (Basel). 2021 Jul 30;11(8): [PMID: 34436348]
  18. Front Cardiovasc Med. 2021 Jul 07;8:686558 [PMID: 34307500]
  19. J Thorac Dis. 2018 Mar;10(Suppl 5):S606-S612 [PMID: 29732177]
  20. Semin Thromb Hemost. 2018 Feb;44(1):20-29 [PMID: 28898902]
  21. J Thorac Dis. 2015 Jul;7(7):E166-76 [PMID: 26380745]
  22. J Clin Med. 2023 Aug 26;12(17): [PMID: 37685643]
  23. Cureus. 2019 Sep 20;11(9):e5709 [PMID: 31720177]
  24. Eur J Med Res. 2023 Oct 10;28(1):412 [PMID: 37814326]

Word Cloud

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