There is very little research on the relationship between interpersonal adverse childhood experiences and depressive symptoms in later adulthood in China. This study examines gender differences in the relationships between childhood physical abuse, bullying victimization, witnessing domestic violence, and depressive symptoms in Chinese middle-aged and older adults, controlling for self-rated physical health and sociodemographic characteristics.The study was based on a nationally representative sample of 4,775 males and 5,596 females aged 45 and older collected through the China Health and Retirement Longitudinal Study (CHARLS). Childhood adversity indicators in the 2014 Life History Survey were merged with the harmonized 2018 CHARLS dataset. Structural equation modeling was conducted for males and females simultaneously.Physical abuse was not significantly associated with depressive symptoms for either males or females. However, bullying victimization was significantly associated with depressive symptoms for both males and females. This association was stronger for males compared to females, but the gender difference was not statistically significant. Additionally, witnessing domestic violence had a significant association with depressive symptoms for both males and females, with a stronger association for females but this gender difference also was not statistically significant.Being bullied and witnessing domestic violence were still influential in middle and late life. To provide more effective prevention and interventions, further investigations are needed regarding the mechanisms behind the significant relationships and to explore why childhood physical abuse was not significantly associated with depressive symptoms among these Chinese participants.