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Echocardiography (Mount Kisco, N.Y.)
Mar, 2025;42 (3): e70091.

Right Atrial Function and Right Ventricular Diastolic Function and Their Relation With Exercise Capacity in OSAS.

Bang Du, Shuxin Liang, Rui Zhang, Wenjia Shi, Ruonan Wang, Yahong Qin, Aiai Chu
Author Information
  1. Bang Du: Department of Echocardiography, The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, China. ORCID
  2. Shuxin Liang: Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine, Shenzhen, China.
  3. Rui Zhang: Department of Echocardiography, The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, China.
  4. Wenjia Shi: Department of Echocardiography, The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, China.
  5. Ruonan Wang: Department of Echocardiography, The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, China.
  6. Yahong Qin: Department of Echocardiography, The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, China.
  7. Aiai Chu: Department of Echocardiography, The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, China.
PMID: 40089901 DOI: 10.1111/echo.70091

Abstract

BACKGROUND: Right ventricular (RV) diastolic function and right atrial (RA) function are poorly characterized in patients with obstructive sleep apnea syndrome (OSAS), but may influence exercise capacity. We aimed to evaluate RA function and RV diastolic function in OSAS and study their relationship with exercise capacity.
METHODS: Fifty-three patients with OSAS and thirty age- and gender-matched controls prospectively underwent echocardiography and cardiopulmonary exercise testing to investigate RV diastolic function, RA function, and exercise capacity.
RESULTS: Altered RV diastolic function in patients with severe OSAS was indicated by the increased tricuspid valve E/e' ratio (TV E/e'), isovolumic relaxation time (IVRT), and by the reduced RV TDI e' velocity. The TV E/e' correlated modestly with peak VO (r = -0.334, p < 0.01). Patients with severe OSAS exhibited impaired RA total emptying fraction, RA passive emptying fraction, and RA reservoir strain (RARS), with RARS being associated with peak oxygen uptake (VO) (r = 0.451, p < 0.01 for reservoir function).
CONCLUSION: Altered RA function and RV diastolic function in patients with OSAS are associated with impaired exercise capacity. The correlation of RA function and RV diastolic function with exercise capacity suggests that it may be important to evaluate RA function and RV diastolic function in this population.

Keywords

echocardiography exercise capacity obstructive sleep apnea syndrome right atrial function right ventricular function

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Grants

  1. JCYJ20210324122410028/Shenzhen Science and Technology Program
  2. SKLRD-OP-202403/202301/Open Project of State Key Laboratory of Respiratory Disease
  3. 19SYPYB-2/In-Hospital Cultivation Fund of Gansu Provincial Hospital
  4. projectnumber���SKLRD-OP-202504)./the State Key Laboratory of Respiratory Disease-Open Project

MeSH Term

Humans
Female
Male
Sleep Apnea, Obstructive
Middle Aged
Exercise Tolerance
Exercise Test
Heart Atria
Prospective Studies
Atrial Function, Right
Diastole
Echocardiography
Ventricular Function, Right
Ventricular Dysfunction, Right
Journal Article

Word Cloud

Created with Highcharts 10.0.0functionRARVdiastolicOSASexercisecapacitypatientsRightrightE/e'ventricularatrialobstructivesleepapneasyndromemayevaluateechocardiographyAlteredsevereTVpeakVOr=p< 001impairedemptyingfractionreservoirRARSassociatedFunctionBACKGROUND:poorlycharacterizedinfluenceaimedstudyrelationshipMETHODS:Fifty-threethirtyage-gender-matchedcontrolsprospectivelyunderwentcardiopulmonarytestinginvestigateRESULTS:indicatedincreasedtricuspidvalveratioisovolumicrelaxationtimeIVRTreducedTDIe'velocitycorrelatedmodestly-0334Patientsexhibitedtotalpassivestrainoxygenuptake0451CONCLUSION:correlationsuggestsimportantpopulationAtrialVentricularDiastolicRelationExerciseCapacity

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