Innovative Botulinum Toxin Injection: A Promising Nonsurgical Solution for Carpometacarpal Osteoarthritis.

Samuel Ivan Bartlett, Chad David Hulsopple
Author Information
  1. Samuel Ivan Bartlett: Core Faculty, Martin Army Community Hospital Family Medicine Residency, Fort Moore, Georgia; and.
  2. Chad David Hulsopple: Department of Family Medicine, Uniformed Services, Fort Belvoir, Virginia.

Abstract

ABSTRACT: Carpometacarpal joint (CMCJ) osteoarthritis (OA) is a common condition that can cause significant pain and functional limitations. Although mild-to-moderate CMCJ OA symptoms can be managed with conservative measures, effective nonsurgical options for patients with moderate-to-severe OA unresponsive to conservative measures are limited. This case report introduces a novel approach involving intra-articular incobotulinumtoxinA (BoNTA) injection for CMCJ OA, resulting in significant and prolonged pain relief and enhanced functionality. This groundbreaking intervention effectively bridges the gap between nonsurgical and surgical treatments, offering a promising alternative for individuals with CMCJ OA.

References

  1. O'Shaughnessy MA, Rizzo M. Nonoperative management of carpometacarpal joint arthritis. Hand Clin. 2022;38:161���168.
  2. Day CS, Gelberman R, Patel AA, et al. Basal joint osteoarthritis of the thumb: a prospective trial of steroid injection and splinting. J Hand Surg Am. 2004;29:247���251.
  3. Ismiarto YD, Prasetiyo GT. Efficacy and safety of intra-articular botulinum toxin A injection for knee osteoarthritis: a systematic review, meta-analysis, and meta-regression of clinical trials. JB JS Open Access. 2023;8:e2200121.
  4. Sconza C, Leonardi G, Carf�� C, et al. Intra-articular injection of botulinum toxin for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Int J Mol Sci. 2023;24:1486.
  5. Wang C, Zhao J, Gao F, et al. The efficacy and safety of intra-articular botulinum toxin type A injection for knee osteoarthritis: a meta-analysis of randomized controlled trials. Toxicon. 2023;224:107026.
  6. Zhai S, Huang B, Yu K. The efficacy and safety of Botulinum Toxin Type A in painful knee osteoarthritis: a systematic review and meta-analysis. J Int Med Res. 2020;48:300060519895868.
  7. Arendt-Nielsen L, Jiang GL, DeGryse R, et al. Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain. Scand J Rheumatol. 2017;46:303���316.
  8. Blanshan N, Krug H. The use of botulinum toxin for the treatment of chronic joint pain: clinical and experimental evidence. Toxins (Basel). 2020;12:314.

Word Cloud

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