This study analyzed solvent extractions of Urelytrum giganteum Pilg, a perennial wild tufted grass in dry tropical African countries, to determine its antioxidant potential, chemical composition, proximate analysis, antimicrobial efficacy, and molecular docking. The ethanolic extract showed the highest antioxidant activity across various assays and showed the most substantial antibacterial activity against all tested bacterial strains. The phytochemicals identified included alkaloids, flavonoids, saponins, phenolic substances, tannins, carbohydrates, terpenes, and C-glycosides. The majority of the phytochemicals demonstrated notable inhibitory activity, with Stigmasterol showing the highest inhibition score.