The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases.
U��ur Alta��, Sevin�� Ta��ar, Nurbanu Ba��do��an, Halil Alkaya, Seda ��evik, Zeynep M Alta��, Mehmet Ya��ar ��zkars
Author Information
U��ur Alta��: Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, T��rkiye.
Sevin�� Ta��ar: Department of Paediatric Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Umraniye, Istanbul, T��rkiye.
Nurbanu Ba��do��an: Department of Paediatric Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Umraniye, Istanbul, T��rkiye.
Halil Alkaya: Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, T��rkiye.
Seda ��evik: Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, T��rkiye.
Zeynep M Alta��: Maltepe District Health Directorate, Istanbul, T��rkiye.
Mehmet Ya��ar ��zkars: Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, T��rkiye.
Introduction: An impaired skin barrier has been reported in allergic diseases. Aim: In this study, we aimed to evaluate dermis thickness in children with house dust allergy without skin symptoms. Material and methods: This cross-sectional study included children aged 4-18 years with asthma and/or allergic rhinitis. Participants were divided into three groups: healthy controls ( = 50), patients sensitized to house dust mites ( = 60), and patients with negative house dust mite tests ( = 48). The thickness of the dermis layers of the skin was measured at the cubital fossa using an ultrasound. Results: The median age and gender distribution were similar across the house dust mite-positive and -negative groups and the healthy control group. There was no significant difference between the groups in terms of dermis thickness ( = 0.053). Absolute eosinophils and eosinophil percentage were significantly negatively correlated with dermis ( < 0.05). There was no significant correlation between total IgE, house dust mite specific IgE and skin test values and skin thickness ( > 0.05). Conclusions: The findings of this study highlight the impact of house dust mite sensitization on skin thickness, offering potential contributions to the management and treatment strategies of allergic diseases.
