OBJECTIVE: To report on the management and outcomes of two dogs treated with osseointegrated prosthesis for pelvic-limb salvage. STUDY DESIGN: Short case series. SAMPLE POPULATION: Two client-owned large breed dogs with distal tibial amputation due to neonatal and iatrogenic trauma. METHODS: Preoperative computed tomography (CT) was performed to assess tibial medullary length and width. A custom-made intramedullary prosthesis was implanted and attached to a 3D-printed external prosthesis simulating a foot. Postoperative care included bandaging and regular chlorhexidine washes. Postoperative monitoring included clinical evaluation, owners' assessment of function and radiographs. RESULTS: Both dogs regained good use of the operated limb within 3���weeks of surgery. Osseointegration and bone remodelling around the implants were noted on radiographs, with no evidence of loosening or implant migration observed. Mild serosanguinous discharge at the cutaneous-implant interface was observed in the early postoperative period, resolving without intervention. Progressive osteolysis around the implants was detected on radiographs in both dogs by 22���months. Though osteomyelitis is suspected, both dogs were using the limb adequately and had satisfactory quality of life at more than 36���months after surgery. A consistent hygiene routine is suspected to delay this process and should theoretically prolong the lifespan of these implants. CONCLUSION: This osseointegrated implant system allowed dogs with traumatic loss of the hindpaw to regain normal clinical function of their pelvic limb for 3���years. Occasional soft tissue infections of the stoma sites were observed, but were easily managed, and long-term (36���month) follow-up suggests durability of the prosthesis. CLINICAL SIGNIFICANCE: These results justify further studies in a larger cohort to assess the long-term durability of osseointegrated prostheses as a single-stage strategy to treat partial limb amputation.
Albrektsson T, Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J 2001;10:S96���S101. https://doi.org/10.1007/s005860100282.
Branemark PI. Osseointegration and its experimental background. J Prosthet Dent 1983;50(3):399���410. https://doi.org/10.1016/s0022-3913(83)80101-2.
Hoellwarth JS, Tetsworth K, Akhtar MA et al. The clinical history and basic science origins of transcutaneous osseointegration for amputees Carl AL, ed. Adv Orthop 2022;2022(1):1���14. https://doi.org/10.1155/2022/7960559.
Marcellin���Little DJ, Drum MG, Levine D et al. Orthoses and exoprostheses for companion animals. Vet Clin North Am Small Anim Pract 2015;45(1):167���183. https://doi.org/10.1016/j.cvsm.2014.09.009.
Wendland TM, Seguin B, Duerr FM. Retrospective multi���center analysis of canine socket prostheses for partial limbs. Front Vet Sci 2019;6(100). https://doi.org/10.3389/fvets.2019.00100.
Gailey R. Review of secondary physical conditions associated with lower���limb amputation and long���term prosthesis use. J Rehabil Res Dev 2008;45(1):15���30. https://doi.org/10.1682/jrrd.2006.11.0147.
Koc E, Tunca M, Akar A et al. Skin problems in amputees: a descriptive study. Int J Dermatol 2008;47(5):463���466. https://doi.org/10.1111/j.1365-4632.2008.03604.x.
Hoellwarth JS, Tetsworth K, Rozbruch SR et al. Osseointegration for amputees: current implants, techniques, and future directions. JBJS Rev 2020;8(3):e0043. https://doi.org/10.2106/jbjs.rvw.19.00043.
Jacobs R, Br��nemark R, Olmarker K et al. Evaluation of the psychophysical detection threshold level for vibrotactile and pressure stimulation of prosthetic limbs using bone anchorage or soft tissue support. Prosthetics Orthot Int 2000;24(2):133���142. https://doi.org/10.1080/03093640008726536.
Whitelock RG, Dyce J, Houlton JE et al. A review of 30 tumours affecting joints. Vet Comp Orthop Traumatol 1997;10(3):146���152. https://doi.org/10.1055/s-0038-1632586.
Fox DB, Cook JL, Kreeger JM et al. Canine synovial sarcoma: a retrospective assessment of described prognostic criteria in 16 cases (1994���1999). J Am Anim Hosp Assoc 2002;38(4):347���355. https://doi.org/10.5326/0380347.
Kirpensteijn J, van den Bos R, Endenburg N. Adaptation of dogs to the amputation of a limb and their owners' satisfaction with the procedure. Vet Rec 1999;144(5):115���118. https://doi.org/10.1136/vr.144.5.115.
Shepherd K. Behavioural changes following limb amputation in dogs. Vet Rec 1999;144(7):185���186.
Dickerson VM, Coleman KD, Ogawa M et al. Outcomes of dogs undergoing limb amputation, owner satisfaction with limb amputation procedures, and owner perceptions regarding postsurgical adaptation: 64 cases (2005���2012). J Am Vet Med Assoc 2015;247(7):786���792. https://doi.org/10.2460/javma.247.7.786.
Fitzpatrick N, Smith TJ, Pendegrass CJ et al. Intraosseous transcutaneous amputation prosthesis (ITAP) for limb salvage in 4 dogs. Vet Surg 2011;40(8):909���925. https://doi.org/10.1111/j.1532-950x.2011.00891.x.
Pendegrass CJ, Goodship AE, Price JS et al. Nature's answer to breaching the skin barrier: an innovative development for amputees. J Anat 2006;209(1):59���67. https://doi.org/10.1111/j.1469-7580.2006.00595.x.
Pendegrass CJ, Gordon D, Middleton CA et al. Sealing the skin barrier around transcutaneous implants. J Bone Joint Surg Br 2008;90(1):114���121. https://doi.org/10.1302/0301-620x.90b1.19580.
Pendegrass CJ, Goodship AE, Blunn GW. Development of a soft tissue seal around bone���anchored transcutaneous amputation prostheses. Biomaterials 2006;27(23):4183���4191. https://doi.org/10.1016/j.biomaterials.2006.03.041.
Al Muderis M, Lu W, Tetsworth K et al. Single���stage osseointegrated reconstruction and rehabilitation of lower limb amputees: the osseointegration Group of Australia Accelerated Protocol���2 (OGAAP���2) for a prospective cohort study. BMJ Open 2017;7(3):e013508. https://doi.org/10.1136/bmjopen-2016-013508.
Al Muderis M, Lu W, Li JJ. Osseointegrated prosthetic limb for the treatment of lower limb amputations. Unfallchirurg 2017;120(4):306���311. https://doi.org/10.1007/s00113-016-0296-8.
Quinn MM, Keuler NS, Lu Y et al. Evaluation of agreement between numerical rating scales, visual analogue scoring scales, and force plate gait analysis in dogs. Vet Surg 2007;36(4):360���367. https://doi.org/10.1111/j.1532-950x.2007.00276.x.
Sugiyama T, Woodward A, Ryan SD. Biomechanical evaluation of 6 transarticular tibiotarsal immobilization methods in canine cadaveric limbs. Vet Surg 2018;47(5):705���714. https://doi.org/10.1111/vsu.12923.
Humphries A, Shaheen AF, G��mez ��lvarez CB. Different conformations of the German Shepherd dog breed affect its posture and movement. Sci Rep 2020;10(1):16924. https://doi.org/10.1038/s41598-020-73550-x.
Tobias KM, Johnston SA. Veterinary surgery: small animal. St. Louis, Missouri: Elsevier, 2018.
Tillander J, Hagberg K, Hagberg L et al. Osseointegrated titanium implants for limb prostheses attachments: infectious complications. Clin Orthop Relat Res 2010;468(10):2781���2788. https://doi.org/10.1007/s11999-010-1370-0.
Haque R, Al���Jawazneh S, Hoellwarth J et al. Osseointegrated reconstruction and rehabilitation of transtibial amputees: the osseointegration Group of Australia surgical technique and protocol for a prospective cohort study. BMJ Open 2020;10(10):e038346. https://doi.org/10.1136/bmjopen-2020-038346.
Melekwe GO, Uwagie���Ero EA, Zoaka HA et al. Comparative clinical effectiveness of preoperative skin antiseptic preparations of chlorhexidine gluconate and povidone iodine for preventing surgical site infections in dogs. Int J Vet Sci Med 2018;6(1):113���116. https://doi.org/10.1016/j.ijvsm.2018.03.005.
Solderer A, Kaufmann M, Hofer D et al. Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review. Clin Oral Investig 2018;23(1):21���32. https://doi.org/10.1007/s00784-018-2761-y.
Xiao D, Lu Y, Zhu L et al. Anti���osteosarcoma property of decorin���modified titanium surface: a novel strategy to inhibit oncogenic potential of osteosarcoma cells. Biomed Pharmacother 2020;125:110034. https://doi.org/10.1016/j.biopha.2020.110034.