The modeling of age-dependent cerebral microangiopathy (CMA) is highly relevant due to its high prevalence and the heavy burden of clinical manifestations - strokes and cognitive disorders in the elderly, as well as the lack of effective pathogenetic treatment. Experimental modeling of CMA is a promising area of preclinical scientific research that contributes to the study of the disease pathogenesis at the genetic, molecular, and cellular levels and the search for optimal methods of its treatment and prevention. This review aimed to analyze, systematize, and compare data on current experimental models of CMA. The review analyzed the results of various studies on experimental models published in journals indexed in the PubMed, Scopus, and eLibrary databases. Available CMA models reflect different CMA attributes and mechanisms. The choice of research model should be based on the experiment's objectives. Understanding available models, combining them, and developing new models should be aimed at choosing the most relevant ones, reproducing the features of modern CMA, characterized by the control of classical risk factors, to assess pathological mechanisms and develop pathogenetic treatment.
