Introduction: recent population-based studies indicated an increasing burden of cardiovascular disease risk factors in sub-Saharan Africa. However, there is limited evidence regarding cardiovascular disease prevention practices among the communities. This study aimed to assess cardiovascular disease prevention practices and associated factors among adults in Jimma Town, Southwest Ethiopia. Methods: a community-based cross-sectional study was conducted among 634 adults in Jimma Town from August 30 to September 30, 2021. A multistage sampling technique was employed to get the study participants. Data were entered into Epi-data version 4.6 and exported to Statistical Package for Social Science version 23 for analysis. Multivariable logistic regression was conducted to identify potential predictors of cardiovascular disease prevention practice. Results: the overall good practice was found to be 46.8%. Knowledge of cardiovascular disease risk factors (AOR = 2.013; 95% CI (1.4, 2.9); p < 0.001), self-efficacy (AOR = 1.670; 95% CI (1.1, 2.4); p = 0.007), social support (AOR = 2.063; 95% CI (1.4, 2.9); p < 001), intermediate (AOR = 2.035; 95% CI (1.3, 3.2); p = 0.003) and high (AOR = 2.101; 95% CI (1.3, 3.4); p = 0. 001) self-perceived estimate of cardiovascular disease risk, and working hours (AOR = 0.445; 95% CI (0.3, 0.7); p < 0.001) were significantly associated with cardiovascular diseases prevention practices. Conclusion: the study found cardiovascular disease prevention practice was suboptimal in the study area. Thus, promoting positive health behaviors regarding cardiovascular disease risk factors in the community is a must.