Platinum-induced ototoxicity in pediatric patients with solid tumors: Younger and male children are more susceptible.
Jie Bai, Yao Song, Xuetong Wang, Zhihan Lin, Yi Zhou, Xin Jin, Ying Li, Zhipeng Zheng, Xueyao Wang, Jifeng Shi, Haihong Liu
Author Information
Jie Bai: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Yao Song: Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Xuetong Wang: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhihan Lin: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Yi Zhou: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Xin Jin: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Ying Li: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhipeng Zheng: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Xueyao Wang: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jifeng Shi: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Haihong Liu: Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: haihongliu6@aliyun.com.
The purpose of this study was to explore prevalence and risk factors of platinum drug-induced ototoxicity, delineate the severity of ototoxicity, and quantify the cumulative dose of platinum-based drugs, in China. This retrospective study involved 108 pediatric solid tumor patients who underwent platinum-containing chemotherapy. We utilized logistics regression to identify risk factors. A threshold for the cumulative dose of platinum-drugs was determined by ROC (receiver operating characteristic curve). The hearing thresholds across sex and age groups were examined. Overall, 37.04 % of patients had ototoxicity as measured audiometrically. The prevalence of males (46.43 %, p = .036) was higher than that of females. The cumulative dose of cisplatin was the most significant risk factor for ototoxicity (p = .002, OR = 1.29, per 100 mg/mm). The cut-off value for the cisplatin cumulative dose was 220 mg/m. Another risk factor is male (p = .037, OR = 2.54). The hearing thresholds at 8 kHz were higher in males (61.81 �� 15.05 dB HL; p = .042)than in females. The group of patients���3 years old showed more pronounced ototoxicity at 6 kHz [66.00 �� 9.37 dB HL]and 8 kHz [70.00 (65.00,80.00)dB HL] than the older group (4-6 years)at 6 kHz and 8 kHz. Ototoxicity in pediatric patients with platinum-containing chemotherapy is ubiquitous in China, which is influenced by cumulative dose of drugs, sex and age. The threshold of cumulative dose deserves attention.
