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Journal of fish diseases
Mar 26, 2025; e14116.

Serum and Tissue Kinetics of Oxolinic Acid in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Temperatures.

Jun Sung Bae, Chae Won Lee, Chan Yeong Yang, Eun Ha Jeong, Jung Soo Seo, Mun-Gyeong Kwon, Ji-Hoon Lee
Author Information
  1. Jun Sung Bae: Department of Aquatic Life Medicine, Kunsan National University, Gunsan, Republic of Korea.
  2. Chae Won Lee: Department of Aquatic Life Medicine, Kunsan National University, Gunsan, Republic of Korea.
  3. Chan Yeong Yang: Department of Aquatic Life Medicine, Kunsan National University, Gunsan, Republic of Korea.
  4. Eun Ha Jeong: Department of Aquatic Life Medicine, Kunsan National University, Gunsan, Republic of Korea.
  5. Jung Soo Seo: Aquatic Disease Control Division, National Fisheries Products Quality Management Service, Busan, Republic of Korea.
  6. Mun-Gyeong Kwon: Aquatic Disease Control Division, National Fisheries Products Quality Management Service, Busan, Republic of Korea.
  7. Ji-Hoon Lee: Department of Aquatic Life Medicine, Kunsan National University, Gunsan, Republic of Korea. ORCID
PMID: 40135728 DOI: 10.1111/jfd.14116

Abstract

The objective of this study was to investigate the pharmacokinetic (PK) properties of oxolinic acid (OA) in black rockfish (Sebastes schlegelii) following a single oral administration of 30���mg/kg at 13��C and 22��C. Serum and tissue (muscle, liver and kidney) samples were collected at pre-determined time points and analysed using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The results demonstrated that temperature significantly influenced the PK parameters of OA. The terminal half-life (t) was prolonged at 22��C across all tissues, while the total body clearance (CL/F) was reduced, suggesting a slower drug elimination at higher temperatures. The peak concentration (C) and the area under the concentration-time curve (AUC) values increased with temperature, indicating enhanced systemic exposure at 22��C. The volume of distribution (Vz/F) decreased from 13��C to 22��C, indicating reduced tissue distribution of OA at the higher temperature. PK/pharmacodynamic (PK/PD) analysis revealed that a single oral dose of 30���mg/kg was insufficient to achieve optimal antibacterial efficacy, implying that higher doses may be necessary. These findings highlight the necessity of temperature-adjusted dosing strategies for OA treatment in black rockfish aquaculture to optimise therapeutic efficacy while minimising antimicrobial resistance risks.

Keywords

black rockfish oxolinic acid (OA) pharmacokinetics temperature

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  1. /Ministry of Oceans and Fisheries
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