In the majority of cases, patients with multiple myeloma (MM) generally exhibit normal or decreased blood lipid levels. However, a minority of cases demonstrate the significant role of M protein in elevated lipid levels, particularly in the close association between IgA type MM and hypertriglyceridemia and hypercholesterolemia. Here, we report a case of IgA-κ type MM with concurrent hyperlipidemia, wherein the patient presented with elevated lipid levels upon admission: total cholesterol of 10.44 mmol/L (normal range: 2.8-5.6 mmol/L) and triglycerides of 28.45 mmol/L (normal range: 0.45-1.70 mmol/L). The patient also had concurrent multiple myeloma and was treated with the PCD regimen along with lipid-lowering measures, hydration, alkalization, liver protection, and symptomatic supportive care, and showed a significant improvement in symptoms and was discharged. The aim was to explore the relationship between IgA type MM and hyperlipidemia, and then provide guidance for clinical diagnosis and treatment.
