Post-operative infection following ankle fracture surgery: a current concepts review.

Jasper Tausendfreund, Jens Halm, Erik Tanis, Michael Swords, Tim Schepers
Author Information
  1. Jasper Tausendfreund: Trauma Unit, Noordwest Hospital Group, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands. ORCID
  2. Jens Halm: Trauma Unit, Amsterdam University Medical Center, Amsterdam Movement Sciences, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. ORCID
  3. Erik Tanis: Trauma Unit, Noordwest Hospital Group, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands. ORCID
  4. Michael Swords: Michigan Orthopedic Center, University of Michigan Health-Sparrow, 1215 Michigan Ave, Lansing, MI, USA. ORCID
  5. Tim Schepers: Trauma Unit, Amsterdam University Medical Center, Amsterdam Movement Sciences, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. t.schepers@amsterdamumc.nl. ORCID

Abstract

PURPOSE: The most common early complication of operative treatment of ankle fractures is a surgical site infection (SSI) with an incidence rate varying between 1.5 and 16%, depending on various risk factors. A SSI has multiple disadvantages, including worse outcome and a socio-economic burden. The aim of this review is to provide an updated overview of the current concepts pertinent to SSI in ankle fractures.
METHODS: A descriptive literature review was performed to provide the overview.
RESULTS: Well known risk factors for SSI are higher age, diabetes, open fractures and fracture dislocation. Diagnostic testing for infection include laboratory results (CRP, white blood cell count, leucocyte count), radiological imaging methods (conventional imaging, CT-scan, MRI-scan, 3-phase bone scan, FDG-PET) and microbiological deep tissue sampling. Treatment options for SSI are varied and include fracture reduction, antibiotic therapy with intravenous and oral treatment, surgical debridement and irrigation, transposition flaps in case of soft tissue defects with implant exposure and arthrodesis in severe infection with septic arthritis. Multiple studies show worse outcome scores in patients who develop a SSI. Prevention is important to reduce the rate of SSI. Surgery within 24 h decreases the risk of complications, compared to surgery performed in a delayed fashion. Appropriate timing and dosing of preoperative antibiotic prophylaxis is necessary.
CONCLUSION: This review described the most frequent risk factors, appropriate diagnostic testing methods, an oversight of treatment options, gives insight in the outcome and mentioned prevention measurements for SSI after ORIF in ankle fractures.

Keywords

References

  1. Foot Ankle Int. 2012 Mar;33(3):173-8 [PMID: 22734277]
  2. Foot Ankle Surg. 2022 Jul;28(5):550-556 [PMID: 34321185]
  3. J Bone Joint Surg Br. 1991 May;73(3):511-3 [PMID: 1670461]
  4. J Clin Med. 2023 Jun 22;12(13): [PMID: 37445250]
  5. Eur J Trauma Emerg Surg. 2020 Feb;46(1):121-130 [PMID: 30251154]
  6. Arch Orthop Trauma Surg. 1999;119(5-6):276-9 [PMID: 10447622]
  7. Clin Orthop Relat Res. 2003 Sep;(414):7-24 [PMID: 12966271]
  8. Foot Ankle Int. 2000 Apr;21(4):311-9 [PMID: 10808971]
  9. Joints. 2018 May 21;6(2):110-115 [PMID: 30051108]
  10. Acta Orthop Scand. 1983 Aug;54(4):641-7 [PMID: 6422695]
  11. Injury. 2006 May;37 Suppl 2:S59-66 [PMID: 16651073]
  12. Ann Chir Gynaecol. 2000;89(1):6-9 [PMID: 10791637]
  13. Eur J Med Res. 2010 Feb 26;15(2):54-8 [PMID: 20452884]
  14. Acta Orthop. 2012 Jun;83(3):276-81 [PMID: 22401675]
  15. BMC Musculoskelet Disord. 2014 Apr 12;15:128 [PMID: 24725554]
  16. J Orthop Sports Phys Ther. 2014 Sep;44(9):690-701, C1-7 [PMID: 25098197]
  17. Acta Orthop Suppl. 2015 Feb;86(358):1-32 [PMID: 25586467]
  18. Medicine (Baltimore). 2018 Feb;97(7):e9901 [PMID: 29443762]
  19. Acta Orthop Belg. 2018 Dec;84(4):397-406 [PMID: 30879443]
  20. Foot Ankle Int. 2015 Sep;36(9):1017-24 [PMID: 25967254]
  21. J Foot Ankle Surg. 2016 Jul-Aug;55(4):762-6 [PMID: 27086177]
  22. J Bone Joint Surg Am. 2013 Feb 20;95(4):348-53 [PMID: 23426769]
  23. Acta Orthop Scand. 1986 Feb;57(1):35-7 [PMID: 3083643]
  24. J Clin Microbiol. 1998 Oct;36(10):2932-9 [PMID: 9738046]
  25. J Orthop Surg Res. 2020 Oct 1;15(1):449 [PMID: 33004062]
  26. Arch Orthop Trauma Surg. 2018 Feb;138(2):189-194 [PMID: 28956151]
  27. Foot Ankle Surg. 2012 Jun;18(2):103-7 [PMID: 22443995]
  28. Injury. 2023 Oct;54(10):111011 [PMID: 37688812]
  29. Bone Joint J. 2017 Feb;99-B(2):225-230 [PMID: 28148665]
  30. Foot Ankle Int. 2007 Jan;28(1):32-7 [PMID: 17257535]
  31. J Orthop Trauma. 2016 Jul;30(7):345-52 [PMID: 27045369]
  32. Injury. 2018 Oct;49(10):1931-1935 [PMID: 30077358]
  33. Foot Ankle Surg. 2018 Feb;24(1):34-39 [PMID: 29413771]
  34. Bone Joint Res. 2019 Nov 02;8(10):459-468 [PMID: 31728184]
  35. Foot Ankle Spec. 2020 Apr;13(2):104-111 [PMID: 30913923]
  36. Foot Ankle Int. 1999 Nov;20(11):687-94 [PMID: 10582843]
  37. Int J Surg. 2017 Dec;48:86-91 [PMID: 29050964]
  38. J Orthop Trauma. 2020 Jan;34(1):8-17 [PMID: 31855973]
  39. Open Orthop J. 2009 Jul 22;3:56-60 [PMID: 19657462]
  40. J Trauma. 1999 Dec;47(6):1072-8 [PMID: 10608535]
  41. Health Technol Assess. 2016 Oct;20(75):1-158 [PMID: 27735787]
  42. Rev Esp Cir Ortop Traumatol. 2024 Jul-Aug;68(4):363-372 [PMID: 38043738]
  43. Bone. 2008 Aug;43(2):340-342 [PMID: 18538645]
  44. Injury. 1985 Jan;16(4):265-72 [PMID: 3967916]
  45. Int Orthop. 2013 Mar;37(3):489-94 [PMID: 23288046]
  46. Int J Surg. 2018 Aug;56:124-132 [PMID: 29929022]
  47. Injury. 2015 Aug;46(8):1650-5 [PMID: 25935358]
  48. J Orthop Trauma. 2022 Jan 1;36(1):43-48 [PMID: 34711768]
  49. Foot Ankle Spec. 2024 Oct 5;:19386400241273105 [PMID: 39367857]
  50. Clin Orthop Relat Res. 1985 Oct;(199):28-38 [PMID: 3930122]
  51. Medicine (Baltimore). 2017 Jul;96(29):e6903 [PMID: 28723736]
  52. J Foot Ankle Surg. 2009 May-Jun;48(3):330-9 [PMID: 19423033]
  53. J Clin Med. 2023 Oct 11;12(20): [PMID: 37892601]
  54. Injury. 2021 Jul;52(7):1959-1963 [PMID: 33896610]
  55. Foot Ankle Surg. 2017 Dec;23(4):311-316 [PMID: 29202994]
  56. JAMA Surg. 2017 Aug 01;152(8):784-791 [PMID: 28467526]
  57. J Bone Joint Surg Am. 2010 Apr;92(4):823-8 [PMID: 20360504]
  58. Surg Infect (Larchmt). 2013 Feb;14(1):73-156 [PMID: 23461695]
  59. Injury. 2013 Jul;44(7):1002-6 [PMID: 23561581]
  60. Injury. 2014 Apr;45(4):780-3 [PMID: 24388418]
  61. OTA Int. 2020 May 06;3(2):e077 [PMID: 33937701]
  62. J Clin Orthop Trauma. 2021 Feb 03;17:44-53 [PMID: 33717970]
  63. Lancet. 2024 Jun 29;403(10446):2787-2797 [PMID: 38848738]
  64. J Foot Ankle Surg. 2010 Jan-Feb;49(1):55-62 [PMID: 20123289]
  65. Acta Orthop Scand. 1998 Feb;69(1):48-50 [PMID: 9524518]
  66. Bone Joint J. 2016 Sep;98-B(9):1248-52 [PMID: 27587528]
  67. Front Microbiol. 2022 Jul 05;13:877060 [PMID: 35865928]
  68. Nucl Med Commun. 2016 Jun;37(6):589-92 [PMID: 26849073]
  69. Clin Microbiol Infect. 2016 May;22(5):457.e1-9 [PMID: 26806134]
  70. Foot Ankle Clin. 2002 Mar;7(1):175-90 [PMID: 12380388]
  71. Eur J Trauma Emerg Surg. 2024 Aug;50(4):1701-1707 [PMID: 38592465]
  72. J Orthop Trauma. 2015 Dec;29(12):e476-82 [PMID: 25785357]
  73. Foot Ankle Int. 2018 Nov;39(11):1278-1282 [PMID: 30035617]
  74. Dtsch Arztebl Int. 2014 May 23;111(21):377-88 [PMID: 24939377]
  75. J Orthop Trauma. 2020 Jan;34(1):30-41 [PMID: 31567902]
  76. Foot Ankle Surg. 2021 Dec;27(8):879-883 [PMID: 33277173]
  77. J Foot Ankle Surg. 2018 Sep - Oct;57(5):942-947 [PMID: 30005967]
  78. Foot Ankle Int. 2009 Jul;30(7):666-74 [PMID: 19589314]
  79. Int J Clin Pract. 2023 Apr 25;2023:4839701 [PMID: 37153693]
  80. Foot Ankle Int. 2019 May;40(5):526-536 [PMID: 30688533]
  81. Clin Orthop Relat Res. 2014 Jun;472(6):1921-9 [PMID: 24577615]
  82. JAMA. 2017 Dec 26;318(24):2438-2445 [PMID: 29279933]
  83. Int Wound J. 2024 Apr;21(4):e14581 [PMID: 38112250]
  84. Clin Orthop Relat Res. 2015 Mar;473(3):1133-9 [PMID: 25337977]
  85. Injury. 2023 Mar;54(3):841-847 [PMID: 36610943]
  86. J Orthop Surg (Hong Kong). 2015 Apr;23(1):59-61 [PMID: 25920646]
  87. Bone. 2002 Sep;31(3):430-3 [PMID: 12231418]
  88. OTA Int. 2023 Feb 21;6(1):e223 [PMID: 36846524]
  89. Orthopedics. 2015 Nov;38(11):e1025-33 [PMID: 26558667]
  90. J Foot Ankle Surg. 2017 Mar - Apr;56(2):287-290 [PMID: 28089125]
  91. BMC Surg. 2015 May 01;15:52 [PMID: 25925742]
  92. J Bone Joint Surg Br. 2005 Apr;87(4):489-95 [PMID: 15795198]
  93. N Engl J Med. 2019 Jan 31;380(5):425-436 [PMID: 30699315]
  94. J Foot Ankle Surg. 2016 Sep-Oct;55(5):939-43 [PMID: 27338653]
  95. Int Wound J. 2020 Jun;17(3):842-850 [PMID: 32219994]
  96. J Orthop Trauma. 2011 Dec;25(12):748-55 [PMID: 21886001]
  97. Unfallchirurg. 2012 Jun;115(6):511-7 [PMID: 21165587]
  98. J Bone Joint Surg Am. 2012 Nov 21;94(22):2047-52 [PMID: 23172322]
  99. Injury. 2003 Dec;34(12):928-31 [PMID: 14636737]
  100. J Foot Ankle Surg. 2011 Jan-Feb;50(1):25-30 [PMID: 21172639]
  101. Int Wound J. 2018 Dec;15(6):971-977 [PMID: 30091528]
  102. Lancet Infect Dis. 2020 Oct;20(10):1182-1192 [PMID: 32470329]
  103. Ir J Med Sci. 2013 Sep;182(3):453-6 [PMID: 23354494]
  104. Injury. 2018 Mar;49(3):511-522 [PMID: 27639601]
  105. Ned Tijdschr Geneeskd. 2019 Apr 11;163: [PMID: 31050271]
  106. Unfallchirurgie. 1986 Oct;12(5):241-6 [PMID: 3798588]
  107. Iowa Orthop J. 2005;25:47-52 [PMID: 16089072]
  108. Injury. 2014 Dec;45(12):2029-34 [PMID: 25458066]
  109. Acta Orthop Scand. 1987 Oct;58(5):539-44 [PMID: 3425285]
  110. OTA Int. 2021 Jul 21;4(3):e139 [PMID: 34746671]
  111. J Bone Joint Surg Br. 1991 Jan;73(1):79-82 [PMID: 1991782]
  112. Foot Ankle Surg. 2010 Jun;16(2):96-100 [PMID: 20483143]
  113. Cureus. 2022 Feb 16;14(2):e22270 [PMID: 35350520]
  114. Foot Ankle Int. 2016 Apr;37(4):401-6 [PMID: 26830839]
  115. Arch Orthop Trauma Surg. 2011 Nov;131(11):1545-53 [PMID: 21713539]
  116. Am J Infect Control. 1999 Apr;27(2):97-132; quiz 133-4; discussion 96 [PMID: 10196487]
  117. Injury. 2011 Oct;42(10):1125-9 [PMID: 21329921]
  118. J Bone Joint Surg Am. 2009 May;91(5):1042-9 [PMID: 19411451]
  119. J Orthop Trauma. 2005 Oct;19(9):635-9 [PMID: 16247309]
  120. BMC Musculoskelet Disord. 2018 Dec 13;19(1):441 [PMID: 30545314]
  121. Acta Orthop Belg. 2020 Sep;86(3):563-574 [PMID: 33581043]
  122. Bone Joint J. 2014 May;96-B(5):636-40 [PMID: 24788498]
  123. Acta Orthop. 2008 Jun;79(3):428-32 [PMID: 18622849]
  124. Acta Orthop. 2011 Aug;82(4):489-93 [PMID: 21657968]
  125. Orthopade. 2005 Dec;34(12):1216-28 [PMID: 16235088]

MeSH Term

Humans
Surgical Wound Infection
Ankle Fractures
Risk Factors
Anti-Bacterial Agents
Debridement
Antibiotic Prophylaxis
Fracture Fixation, Internal

Chemicals

Anti-Bacterial Agents

Word Cloud

Created with Highcharts 10.0.0SSIinfectionanklefracturesriskfactorsreviewtreatmentoutcomefracturesurgicalsiterateworseprovideoverviewcurrentconceptsperformedtestingincludecountimagingmethodstissueoptionsreductionantibioticPURPOSE:commonearlycomplicationoperativeincidencevarying1516%dependingvariousmultipledisadvantagesincludingsocio-economicburdenaimupdatedpertinentMETHODS:descriptiveliteratureRESULTS:WellknownhigheragediabetesopendislocationDiagnosticlaboratoryresultsCRPwhitebloodcellleucocyteradiologicalconventionalCT-scanMRI-scan3-phasebonescanFDG-PETmicrobiologicaldeepsamplingTreatmentvariedtherapyintravenousoraldebridementirrigationtranspositionflapscasesoftdefectsimplantexposurearthrodesisseveresepticarthritisMultiplestudiesshowscorespatientsdevelopPreventionimportantreduceSurgerywithin24 hdecreasescomplicationscomparedsurgerydelayedfashionAppropriatetimingdosingpreoperativeprophylaxisnecessaryCONCLUSION:describedfrequentappropriatediagnosticoversightgivesinsightmentionedpreventionmeasurementsORIFPost-operativefollowingsurgery:AnkleFracture-relatedOpeninternalfixationRiskSurgical

Similar Articles

Cited By