Role of comprehensive geriatric assessment, G8 and HOF score: how can we predict mortality in older patients with hematological malignancies?

F��rat Akag��nd��z, Nurdan ��ent��rk Durmu��, Yasin Y��ld��z, Zeynep Be��������k Y��lmaz, ��i��dem Alka��, B����ra Can, Asl�� Tufan
Author Information
  1. F��rat Akag��nd��z: Department of Internal Medicine, Marmara School of Medicine, Marmara University, Istanbul, T��rkiye. ORCID
  2. Nurdan ��ent��rk Durmu��: Department of Internal Medicine, Division of Geriatrics, Marmara University Medical School, Istanbul, T��rkiye. ORCID
  3. Yasin Y��ld��z: Department of Internal Medicine, Division of Geriatrics, Marmara University Medical School, Istanbul, T��rkiye. ORCID
  4. Zeynep Be��������k Y��lmaz: Department of Internal Medicine, Division of Geriatrics, Marmara University Medical School, Istanbul, T��rkiye. ORCID
  5. ��i��dem Alka��: Department of Internal Medicine, Division of Geriatrics, Marmara University Medical School, Istanbul, T��rkiye. ORCID
  6. B����ra Can: Department of Internal Medicine, Division of Geriatrics, Marmara University Medical School, Istanbul, T��rkiye. ORCID
  7. Asl�� Tufan: Department of Internal Medicine, Division of Geriatrics, Marmara University Medical School, Istanbul, T��rkiye. ORCID

Abstract

Comprehensive geriatric assessment (CGA) is recommended for the evaluation of older patients with hematological malignancies. We investigated the association between CGA and mortality during hospitalization and at 1-year follow-up. Frailty was assessed by FRAIL scale, nutritional status by Mini-Nutritional Assessment-Short Form (MNA-SF), sarcopenia risk status by SARC-F. The Haema-Oncology Frailty (HOF) and Geriatric-8 (G8) scores were calculated prior to treatment. Most of the participants had malnutrition or risk of malnutrition based on the MNA-SF score. Half of the participants had risk of sarcopenia (���=���42, 50%). According to the FRAIL score, 51.2% (n:43) of the patients were FRAIL and 38.1% (n:32) were pre-FRAIL. Frailty was identified in 42.9% (���=���36) (HOF scores). Frailty (���=���0.007) and sarcopenia risk (���=���0.044) were linked to in-hospital mortality, the risk of 1-year mortality increased with higher HOF scores (���=���0.040). Findings from this study support the use of the FRAIL scale, SARC-F, and HOF score in clinical settings.

Keywords

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