| Gene Symbol | PLEKHA1 |
| Description | pleckstrin homology domain containing A1 |
| Ensembl ID | ENSG00000107679.14 |
| Location | chr10: 122374696 - 122442602 |
| Cytogenetic Region | 10q26.13 |
| Strand | + |
| Gene Type | protein_coding |
| Also Known As | TAPP1 |
| Summary | This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is lo ... |
| Links To |
Reported Trait | Mapped Trait | Tissue | Gene Symbol | Ensembl ID | Gene Type | Method/Software | Effect Size | P-value | Publication |
|---|---|---|---|---|---|---|---|---|---|
| Any Migraine | Migraine Disorder | Brain Hippocampus | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -5.32E+00 | 1.05E-07 | TWASP000056 |
| Any Migraine | Migraine Disorder | Brain Hippocampus | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -5.32E+00 | 1.05E-07 | TWASP000054 |
| Age-related Macular Degeneration | Age-Related Macular Degeneration | Brain Cerebellum | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -9.57E+00 | 1.05E-21 | TWASP000056 |
| Macdegen | Macular Degeneration | Ovary | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -1.07E+01 | 1.06E-26 | TWASP000054 |
| Macular Degeneration | Macular Degeneration | Breast Mammary Tissue | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -7.12E+00 | 1.09E-12 | TWASP000056 |
| Macdegen | Macular Degeneration | Breast Mammary Tissue | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -7.12E+00 | 1.09E-12 | TWASP000054 |
| Type-2 Diabetes | Type 2 Diabetes Mellitus | Artery Tibia | PLEKHA1 | ENSG00000107679.14 | protein-coding | FUSION | 6.09E+00 | 1.11E-09 | TWASP000150 |
| Age-related Macular Degeneration | Age-Related Macular Degeneration | Thyroid | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -1.83E+01 | 1.11E-74 | TWASP000056 |
| Age-related Macular Degeneration | Age-Related Macular Degeneration | Thyroid | PLEKHA1 | ENSG00000107679.14 | protein-coding | Summary-PrediXcan(S-PrediXcan) | -1.83E+01 | 1.11E-74 | TWASP000054 |
| Type-2 Diabetes | Type 2 Diabetes Mellitus | Adipose | PLEKHA1 | ENSG00000107679.14 | protein-coding | FUSION | 5.71E+00 | 1.14E-08 | TWASP000150 |
Gene Symbol | SNP | Ref Allele | Alt Allele | SNP Location | Effect Size | P-value | Tissue |
|---|---|---|---|---|---|---|---|
| PLEKHA1 | rs2421021 | A | G | chr10:122397530 | -0.167672 | 2.54691e-10 | Adipose_Subcutaneous |
| PLEKHA1 | rs180901369 | G | A | chr10:122443102 | 0.198131 | 1.80895e-07 | Adipose_Subcutaneous |
| PLEKHA1 | rs145368529 | TCCTGTCAGTTTAC | T | chr10:122379180 | 0.347928 | 1.94843e-10 | Brain_Cerebellum |
| PLEKHA1 | rs7900012 | C | T | chr10:122374526 | -0.291812 | 7.85564e-12 | Cells_Cultured_fibroblasts |
| PLEKHA1 | rs145368529 | TCCTGTCAGTTTAC | T | chr10:122379180 | 0.196715 | 4.12548e-08 | Cells_Cultured_fibroblasts |
| PLEKHA1 | rs11200592 | T | C | chr10:122379431 | -0.180886 | 5.78143e-06 | Cells_Cultured_fibroblasts |
| PLEKHA1 | rs2672602 | T | C | chr10:122457309 | -0.639263 | 3.1445e-09 | Cells_EBV-transformed_lymphocytes |
| PLEKHA1 | rs10082476 | A | G | chr10:122405138 | 0.272042 | 4.51756e-12 | Colon_Sigmoid |
| PLEKHA1 | rs3763764 | A | G | chr10:122460545 | -0.177074 | 5.93036e-06 | Colon_Sigmoid |
| PLEKHA1 | rs11200607 | C | T | chr10:122395110 | 0.226345 | 1.14545e-09 | Esophagus_Mucosa |
