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项目编号 PRJCA003775
项目标题 T and B cell receptor repertoire of COVID-19 patients
涉及领域 Medical
数据类型 Raw sequence reads
Assembly
物种名称 Homo sapiens
描述信息 We collected 23 peripheral blood mononuclear cells (PBMCs) samples from COVID-19 patients. We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze T (TCR) and B cell receptor (BCR) repertoires. In this study, iR-RepSeq-plus 7-Chain Cassette was used to generate NGS libraries covering all TCR and BCR chains including TCR-beta, -alpha, -delta, -gamma, and BCR-IgH, -IgK, -IgL. All seven chains were amplified in a single assay.
样品范围 Multiisolate
发布日期 2020-10-28
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients Frontiers in Immunology 10.3389/fimmu.2020.582010 2020
33117392 Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients Frontiers in Immunology 10.3389/fimmu.2020.582010 2020
33408723 Corrigendum: Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients Frontiers in Immunology 10.3389/fimmu.2020.633815 2020
36151403 SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope Nature Microbiology 10.1038/s41564-022-01235-4 2022
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 81661148056 Analysis of antibody repertoires in patients to elucidate the mechanism of antibody response after 2019-nCoV infection
提交者 Ling Chen (chen_ling@gibh.ac.cn)
提交单位 The First Affiliated Hospital of Guangzhou Medical University
提交日期 2020-10-28

项目包含数据信息

资源名称 描述
BioSample (23)  show -