| Accession |
PRJCA014820 |
| Title |
Single-cell Sequence Data of Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated CD8+ exhausted T cells (Tex) in HNSCC. We performed cell level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. A proliferative exhausted CD8+ T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. P-Tex cells could aggregate in the antigen presenting cell niches and activate certain signaling pathways. Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. |
| Sample scope |
Single cell |
| Release date |
2023-02-16 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38655196
|
The diversity of inhibitory receptor co-expression patterns of exhausted CD8+ T cells in oropharyngeal carcinoma
|
IScience
|
10.1016/j.isci.2024.109668
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82002868
|
|
|
|
| Submitter |
Yu
Zhao (yutzhao@vip.163.com)
|
| Organization |
West China Hospital of Sichuan University |
| Submission date |
2023-02-08 |
