e.g., HRA000087; HRA000150
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HRA003921
Title:
Single-cell Sequence Data of Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma
Release date:
2023-02-16
Description:
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated CD8+ exhausted T cells (Tex) in HNSCC. We performed cell level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. A proliferative exhausted CD8+ T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. P-Tex cells could aggregate in the antigen presenting cell niches and activate certain signaling pathways.
Data Accessibility:   
Open access
BioProject:
PRJCA014820
Study type:
Disease Study
Disease name:
head and neck squamous cell carcinoma
Dataset Download
MetaData:
HRA003921.xlsx
Files:
HTTPS：https://download.cncb.ac.cn/gsa-human/HRA003921
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FTP：ftp://download.big.ac.cn/gsa-human/HRA003921

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Submitter:   Zhao Yu / yutzhao@vip.163.com
Organization:   West China Hospital of Sichuan University
Submission date:   2023-02-08