Accession

PRJCA019575

Title

A Proteogenomic Analysis of Cervical Cancer in East Asia Reveals Biological Insights and Therapeutic Signatures

Relevance

Medical

Data types

Exome
Transcriptome or Gene expression
proteomic, phosphoproteomic, acetylproteomic

Organisms

Homo sapiens

Description

Cervical cancer remains the fourth most common malignancy and the fourth leading cause of cancer mortality in women. Unlike many other cancers lacking direct etiological association with virus infection, persistent human papillomavirus infection is the central cause of CC, and over 90% of CC patients are associated with HPV infection at the time of diagnosis. Although HPV vaccination may reduce disease risk, CC remains a severe threat to women's health in low- and middle-income countries due to financial constraints and the shortage of HPV vaccine supply . Patients with early-stage CC who are referred for radical hysterectomy with pelvic lymphadenectomy generally have a good prognosis; nevertheless, the five-year overall survival rate of IIB-IVA stage CC patients was only 36.5%. For middle and advanced stage patients, platinum-based chemoradiotherapy is recommended as an effective treatment option. However, the pelvic lymph node is frequently missed during radiotherapy, and CC patients with special pathological subtypes are either not sensitive to radiation or experience substantial side effects, resulting in a poor treatment outcome and a high recurrence rate. There is an urgent need in clinical practice to enhance the efficacy of radiotherapy for advanced patients. Investigating the molecular mechanism of CC development and its HPV association and identifying candidate biomarkers or therapeutic targets could improve individualized diagnosis and therapy for CC, which would greatly improve patient survival and quality of life.In this study, we used CPTAC guidelines(Rodriguez, Zenklusen et al. 2021) to perform integrated genomic, transcriptomic, proteomic, phosphoproteomic, and acetylproteomic analyses on 139 Chinese CC patients. Our proteogenomic study discovered: 1) HPV-promoted phenotypic perturbations at multi-omics levels; 2) proteomic subgroups associated with distinct clinical and biological features; 3) PRKCB as a biomarker for predicting the efficacy of radiotherapy; and 4) acetylation of FOSL2-K222 by EP300 accelerating malignant proliferation. The underlying data presented here serves as a valuable resource for advancing research in various aspects of CC, including biology, diagnosis, treatment strategies, and the exploration of potential therapeutic drugs.

Sample scope

Multiisolate

Release date

2024-10-08

Biomaterial provider

National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Grants

Agency	program	Grant ID	Grant title
National Key Research and Development Program of China		2022YFA1302900
Shanghai Young Excellent Academic Leader Program		20XD1424900

Submitter

Hu Zhou (zhouhu@simm.ac.cn)

Organization

Shanghai Institute of Materia Medica

Submission date

2023-09-06

Project Data

Resource name	Description
BioSample (287) show	-
SAMC3084699	B112-2-tissue whole exon sequencing data
SAMC3084698	B107-2-tissue whole exon sequencing data
SAMC3084697	B103-1-tissue whole exon sequencing data
SAMC3084696	N34-2-transcriptomic data, and whole exon sequencing data
SAMC3084695	N34-1-transcriptomic data, and whole exon sequencing data
SAMC3084694	N33-2-transcriptomic data, and whole exon sequencing data
SAMC3084693	B162-transcriptomic data, and whole exon sequencing data
SAMC3084692	B161-transcriptomic data, and whole exon sequencing data
SAMC3084691	B160-transcriptomic data, and whole exon sequencing data
SAMC3084690	B159-transcriptomic data, and whole exon sequencing data
SAMC3084689	B158-transcriptomic data, and whole exon sequencing data
SAMC3084688	B156-transcriptomic data, and whole exon sequencing data
SAMC3084687	B155-transcriptomic data, and whole exon sequencing data
SAMC3084686	B154-transcriptomic data, and whole exon sequencing data
SAMC3084685	B153-transcriptomic data, and whole exon sequencing data
SAMC3084684	B152-transcriptomic data, and whole exon sequencing data
SAMC3084683	B151-transcriptomic data, and whole exon sequencing data
SAMC3084682	B150-transcriptomic data, and whole exon sequencing data
SAMC3084681	B149-transcriptomic data, and whole exon sequencing data
SAMC3084680	B147-transcriptomic data, and whole exon sequencing data
SAMC3084679	B146-transcriptomic data, and whole exon sequencing data
SAMC3084678	B145-transcriptomic data, and whole exon sequencing data
SAMC3084677	B144-transcriptomic data, and whole exon sequencing data
SAMC3084676	B143-transcriptomic data, and whole exon sequencing data
SAMC3084675	B142-2-transcriptomic data, and whole exon sequencing data
SAMC3084674	B141-1-transcriptomic data, and whole exon sequencing data
SAMC3084673	B140-2-transcriptomic data, and whole exon sequencing data
SAMC3084672	B140-1-transcriptomic data, and whole exon sequencing data
SAMC3084671	B139-2-transcriptomic data, and whole exon sequencing data
SAMC3084670	B138-2-transcriptomic data, and whole exon sequencing data
SAMC3084669	B138-1-transcriptomic data, and whole exon sequencing data
SAMC3084668	B137-2-transcriptomic data, and whole exon sequencing data
SAMC3084667	B137-1-transcriptomic data, and whole exon sequencing data
SAMC3084666	B124-transcriptomic data, and whole exon sequencing data
SAMC3084665	B115-2-transcriptomic data, and whole exon sequencing data
SAMC3084664	B115-1-transcriptomic data, and whole exon sequencing data
SAMC3084663	B114-1-transcriptomic data, and whole exon sequencing data
SAMC3084662	B113-2-transcriptomic data, and whole exon sequencing data
SAMC3084661	B113-1-transcriptomic data
SAMC3084660	B111-2-transcriptomic data, and whole exon sequencing data
SAMC3084659	B111-1-transcriptomic data, and whole exon sequencing data
SAMC3084658	B110-2-transcriptomic data, and whole exon sequencing data
SAMC3084657	B110-1-transcriptomic data, and whole exon sequencing data
SAMC3084656	B109-1-transcriptomic data, and whole exon sequencing data
SAMC3084655	B109-2-transcriptomic data, and whole exon sequencing data
SAMC3084654	B108-1-transcriptomic data, and whole exon sequencing data
SAMC3084653	B108-2-transcriptomic data, and whole exon sequencing data
SAMC3084652	B107-1-transcriptomic data, and whole exon sequencing data
SAMC3084651	B106-2-transcriptomic data, and whole exon sequencing data
SAMC3084650	B106-1-transcriptomic data, and whole exon sequencing data
SAMC3084649	B105-1-transcriptomic data, and whole exon sequencing data
SAMC3084648	B104-2-transcriptomic data, and whole exon sequencing data
SAMC3084647	B104-1-transcriptomic data, and whole exon sequencing data
SAMC3084646	B103-2-transcriptomic data, and whole exon sequencing data
SAMC3084645	B102-2-transcriptomic data, and whole exon sequencing data
SAMC3084644	B102-1-transcriptomic data, and whole exon sequencing data
SAMC3084643	B101-2-transcriptomic data, and whole exon sequencing data
SAMC3084642	B101-1-transcriptomic data, and whole exon sequencing data
SAMC3084641	B100-1-transcriptomic data, and whole exon sequencing data
SAMC3084640	B99-1-transcriptomic data, and whole exon sequencing data
SAMC3084639	B97-2-transcriptomic data, and whole exon sequencing data
SAMC3084638	B97-1-transcriptomic data, and whole exon sequencing data
SAMC3084637	B96-2-transcriptomic data, and whole exon sequencing data
SAMC3084636	B96-1-transcriptomic data, and whole exon sequencing data
SAMC3084635	B95-1-transcriptomic data, and whole exon sequencing data
SAMC3084634	B94-2-transcriptomic data, and whole exon sequencing data
SAMC3084633	B94-1-transcriptomic data, and whole exon sequencing data
SAMC3084632	B93-1-transcriptomic data, and whole exon sequencing data
SAMC3084631	B92-2-transcriptomic data, and whole exon sequencing data
SAMC3084630	B92-1-transcriptomic data, and whole exon sequencing data
SAMC3084629	B91-1-transcriptomic data, and whole exon sequencing data
SAMC3084628	B90-2-transcriptomic data, and whole exon sequencing data
SAMC3084627	B90-1-transcriptomic data, and whole exon sequencing data
SAMC3084626	B89-2-transcriptomic data, and whole exon sequencing data
SAMC3084625	B89-1-transcriptomic data, and whole exon sequencing data
SAMC3084624	B88-1-transcriptomic data, and whole exon sequencing data
SAMC3084623	B87-1-transcriptomic data, and whole exon sequencing data
SAMC3084622	B86-2-transcriptomic data, and whole exon sequencing data
SAMC3084621	B86-1-transcriptomic data, and whole exon sequencing data
SAMC3084620	B85-2-transcriptomic data, and whole exon sequencing data
SAMC3084619	B85-1-transcriptomic data, and whole exon sequencing data
SAMC3084618	B76-transcriptomic data, and whole exon sequencing data
SAMC3084617	B45-transcriptomic data, and whole exon sequencing data
SAMC3084616	B40-transcriptomic data, and whole exon sequencing data
SAMC3084615	B39-transcriptomic data, and whole exon sequencing data
SAMC3084614	N32-transcriptomic data, and whole exon sequencing data
SAMC3084613	N31-transcriptomic data, and whole exon sequencing data
SAMC3084612	N28-transcriptomic data, and whole exon sequencing data
SAMC3084611	N27-transcriptomic data, and whole exon sequencing data
SAMC3084610	N26-transcriptomic data, and whole exon sequencing data
SAMC3084609	N24-transcriptomic data, and whole exon sequencing data
SAMC3084608	N21-transcriptomic data, and whole exon sequencing data
SAMC3084607	N19-transcriptomic data, and whole exon sequencing data
SAMC3084606	N17-transcriptomic data, and whole exon sequencing data
SAMC3084605	N15-transcriptomic data, and whole exon sequencing data
SAMC3084604	N12-transcriptomic data, and whole exon sequencing data
SAMC3084603	N10-transcriptomic data, and whole exon sequencing data
SAMC3084602	N9-transcriptomic data, and whole exon sequencing data
SAMC3084601	N7-transcriptomic data, and whole exon sequencing data
SAMC3084600	N3-transcriptomic data, and whole exon sequencing data
SAMC3084599	B135-transcriptomic data, and whole exon sequencing data
SAMC3084598	B134-transcriptomic data, and whole exon sequencing data
SAMC3084597	B133-transcriptomic data, and whole exon sequencing data
SAMC3084596	B130-transcriptomic data, and whole exon sequencing data
SAMC3084595	B126-transcriptomic data, and whole exon sequencing data
SAMC3084594	B125-transcriptomic data, and whole exon sequencing data
SAMC3084593	B123-transcriptomic data, and whole exon sequencing data
SAMC3084592	B121-transcriptomic data, and whole exon sequencing data
SAMC3084591	B120-transcriptomic data, and whole exon sequencing data
SAMC3084590	B119-transcriptomic data, and whole exon sequencing data
SAMC3084589	B118-transcriptomic data, and whole exon sequencing data
SAMC3084588	B117-transcriptomic data, and whole exon sequencing data
SAMC3084587	B116-transcriptomic data, and whole exon sequencing data
SAMC3084586	B84-transcriptomic data, and whole exon sequencing data
SAMC3084585	B82-transcriptomic data, and whole exon sequencing data
SAMC3084584	B81-transcriptomic data, and whole exon sequencing data
SAMC3084583	B80-transcriptomic data, and whole exon sequencing data
SAMC3084582	B78-transcriptomic data, and whole exon sequencing data
SAMC3084581	B77-transcriptomic data, and whole exon sequencing data
SAMC3084580	B75-transcriptomic data, and whole exon sequencing data
SAMC3084579	B74-transcriptomic data, and whole exon sequencing data
SAMC3084578	B72-transcriptomic data, and whole exon sequencing data
SAMC3084577	B71-transcriptomic data, and whole exon sequencing data
SAMC3084576	B69-transcriptomic data, and whole exon sequencing data
SAMC3084575	B65-transcriptomic data, and whole exon sequencing data
SAMC3084574	B64-transcriptomic data, and whole exon sequencing data
SAMC3084573	B63-transcriptomic data, and whole exon sequencing data
SAMC3084572	B62-transcriptomic data, and whole exon sequencing data
SAMC3084571	B61-transcriptomic data, and whole exon sequencing data
SAMC3084570	B60-transcriptomic data, and whole exon sequencing data
SAMC3084569	B59-transcriptomic data, and whole exon sequencing data
SAMC3084568	B58-transcriptomic data, and whole exon sequencing data
SAMC3084567	B55-transcriptomic data, and whole exon sequencing data
SAMC3084566	B53-transcriptomic data, and whole exon sequencing data
SAMC3084565	B52-transcriptomic data, and whole exon sequencing data
SAMC3084564	B51-transcriptomic data, and whole exon sequencing data
SAMC3084563	B50-transcriptomic data, and whole exon sequencing data
SAMC3084562	B49-transcriptomic data, and whole exon sequencing data
SAMC3084561	B46-transcriptomic data, and whole exon sequencing data
SAMC3084560	B48-transcriptomic data, and whole exon sequencing data
SAMC3084559	B47-transcriptomic data, and whole exon sequencing data
SAMC3084558	B43-transcriptomic data, and whole exon sequencing data
SAMC3084557	B42-transcriptomic data, and whole exon sequencing data
SAMC3084556	B41-transcriptomic data, and whole exon sequencing data
SAMC3084555	B38-transcriptomic data, and whole exon sequencing data
SAMC3084554	B37-transcriptomic data, and whole exon sequencing data
SAMC3084553	B36-transcriptomic data, and whole exon sequencing data
SAMC3084552	B33-transcriptomic data, and whole exon sequencing data
SAMC3084551	B32-transcriptomic data, and whole exon sequencing data
SAMC3084550	B31-transcriptomic data, and whole exon sequencing data
SAMC3084549	B29-transcriptomic data, and whole exon sequencing data
SAMC3084548	B28-transcriptomic data, and whole exon sequencing data
SAMC3084547	B27-transcriptomic data, and whole exon sequencing data
SAMC3084546	B26-transcriptomic data, and whole exon sequencing data
SAMC3084545	B24-transcriptomic data, and whole exon sequencing data
SAMC3084544	B23-transcriptomic data, and whole exon sequencing data
SAMC3084543	B17-transcriptomic data, and whole exon sequencing data
SAMC3084542	B12-transcriptomic data, and whole exon sequencing data
SAMC3084541	B8-transcriptomic data, and whole exon sequencing data
SAMC3084540	B6-transcriptomic data, and whole exon sequencing data
SAMC3084539	B4-transcriptomic data, and whole exon sequencing data
SAMC3084538	B3-transcriptomic data, and whole exon sequencing data
SAMC3084537	B2-transcriptomic data, and whole exon sequencing data
SAMC3084536	B1-transcriptomic data
SAMC3084535	N34-1B-Blood whole exon sequencing data
SAMC3084534	B162B-Blood whole exon sequencing data
SAMC3084533	B161B-Blood whole exon sequencing data
SAMC3084532	B160B-Blood whole exon sequencing data
SAMC3084531	B159B-Blood whole exon sequencing data
SAMC3084530	B158B-Blood whole exon sequencing data
SAMC3084529	B156B-Blood whole exon sequencing data
SAMC3084528	B155B-Blood whole exon sequencing data
SAMC3084527	B154B-Blood whole exon sequencing data
SAMC3084526	B153B-Blood whole exon sequencing data
SAMC3084525	B152B-Blood whole exon sequencing data
SAMC3084524	B151B-Blood whole exon sequencing data
SAMC3084523	B150B-Blood whole exon sequencing data
SAMC3084522	B149B-Blood whole exon sequencing data
SAMC3084521	B147B-Blood whole exon sequencing data
SAMC3084520	B146B-Blood whole exon sequencing data
SAMC3084519	B145B-Blood whole exon sequencing data
SAMC3084518	B144B-Blood whole exon sequencing data
SAMC3084517	B143B-Blood whole exon sequencing data
SAMC3084516	B141-1B-Blood whole exon sequencing data
SAMC3084515	B140-1B-Blood whole exon sequencing data
SAMC3084514	B138-1B-Blood whole exon sequencing data
SAMC3084513	B137-1B-Blood whole exon sequencing data
SAMC3084512	B124B-Blood whole exon sequencing data
SAMC3084511	B115-1B-Blood whole exon sequencing data
SAMC3084510	B114-1B-Blood whole exon sequencing data
SAMC3084509	B111-1B-Blood whole exon sequencing data
SAMC3084508	B110-1B-Blood whole exon sequencing data
SAMC3084507	B109-1B-Blood whole exon sequencing data
SAMC3084506	B108-1B-Blood whole exon sequencing data
SAMC3084505	B107-1B-Blood whole exon sequencing data
SAMC3084504	B106-1B-Blood whole exon sequencing data
SAMC3084503	B105-1B-Blood whole exon sequencing data
SAMC3084502	B104-1B-Blood whole exon sequencing data
SAMC3084501	B103-1B-Blood whole exon sequencing data
SAMC3084500	B102-1B-Blood whole exon sequencing data
SAMC3084499	B101-1B-Blood whole exon sequencing data
SAMC3084498	B100-1B-Blood whole exon sequencing data
SAMC3084497	B99-1B-Blood whole exon sequencing data
SAMC3084496	B97-1B-Blood whole exon sequencing data
SAMC3084495	B96-1B-Blood whole exon sequencing data
SAMC3084494	B95-1B-Blood whole exon sequencing data
SAMC3084493	B94-1B-Blood whole exon sequencing data
SAMC3084492	B93-1B-Blood whole exon sequencing data
SAMC3084491	B92-1B-Blood whole exon sequencing data
SAMC3084490	B91-1B-Blood whole exon sequencing data
SAMC3084489	B90-1B-Blood whole exon sequencing data
SAMC3084488	B89-1B-Blood whole exon sequencing data
SAMC3084487	B88-1B-Blood whole exon sequencing data
SAMC3084486	B87-1B-Blood whole exon sequencing data
SAMC3084485	B86-1B-Blood whole exon sequencing data
SAMC3084484	B85-1B-Blood whole exon sequencing data
SAMC3084483	B76B-Blood whole exon sequencing data
SAMC3084482	B45B-Blood whole exon sequencing data
SAMC3084481	B40B-Blood whole exon sequencing data
SAMC3084480	B39B-Blood whole exon sequencing data
SAMC3084479	N32B-Blood whole exon sequencing data
SAMC3084478	N28B-Blood whole exon sequencing data
SAMC3084477	N27B-Blood whole exon sequencing data
SAMC3084476	N26B-Blood whole exon sequencing data
SAMC3084475	N17B-Blood whole exon sequencing data
SAMC3084474	B135B-Blood whole exon sequencing data
SAMC3084473	B134B-Blood whole exon sequencing data
SAMC3084472	B133B-Blood whole exon sequencing data
SAMC3084471	B130B-Blood whole exon sequencing data
SAMC3084470	B126B-Blood whole exon sequencing data
SAMC3084469	B125B-Blood whole exon sequencing data
SAMC3084468	B123B-Blood whole exon sequencing data
SAMC3084467	B121B-Blood whole exon sequencing data
SAMC3084466	B120B-Blood whole exon sequencing data
SAMC3084465	B119B-Blood whole exon sequencing data
SAMC3084464	B118B-Blood whole exon sequencing data
SAMC3084463	B117B-Blood whole exon sequencing data
SAMC3084462	B116B-Blood whole exon sequencing data
SAMC3084461	B84B-Blood whole exon sequencing data
SAMC3084460	B82B-Blood whole exon sequencing data
SAMC3084459	B81B-Blood whole exon sequencing data
SAMC3084458	B80B-Blood whole exon sequencing data
SAMC3084457	B78B-Blood whole exon sequencing data
SAMC3084456	B77B-Blood whole exon sequencing data
SAMC3084455	B75B-Blood whole exon sequencing data
SAMC3084454	B74B-Blood whole exon sequencing data
SAMC3084453	B72B-Blood whole exon sequencing data
SAMC3084452	B71B-Blood whole exon sequencing data
SAMC3084451	B69B-Blood whole exon sequencing data
SAMC3084450	B65B-Blood whole exon sequencing data
SAMC3084449	B64B-Blood whole exon sequencing data
SAMC3084448	B63B-Blood whole exon sequencing data
SAMC3084447	B62B-Blood whole exon sequencing data
SAMC3084446	B61B-Blood whole exon sequencing data
SAMC3084445	B60B-Blood whole exon sequencing data
SAMC3084444	B59B-Blood whole exon sequencing data
SAMC3084443	B58B-Blood whole exon sequencing data
SAMC3084442	B55B-Blood whole exon sequencing data
SAMC3084441	B53B-Blood whole exon sequencing data
SAMC3084440	B52B-Blood whole exon sequencing data
SAMC3084439	B51B-Blood whole exon sequencing data
SAMC3084438	B50B-Blood whole exon sequencing data
SAMC3084437	B49B-Blood whole exon sequencing data
SAMC3084436	B46B-Blood whole exon sequencing data
SAMC3084435	B48B-Blood whole exon sequencing data
SAMC3084434	B47B-Blood whole exon sequencing data
SAMC3084433	B43B-Blood whole exon sequencing data
SAMC3084432	B42B-Blood whole exon sequencing data
SAMC3084431	B41B-Blood whole exon sequencing data
SAMC3084430	B38B-Blood whole exon sequencing data
SAMC3084429	B37B-Blood whole exon sequencing data
SAMC3084428	B36B-Blood whole exon sequencing data
SAMC3084427	B33B-Blood whole exon sequencing data
SAMC3084426	B32B-Blood whole exon sequencing data
SAMC3084425	B31B-Blood whole exon sequencing data
SAMC3084424	B29B-Blood whole exon sequencing data
SAMC3084423	B28B-Blood whole exon sequencing data
SAMC3084422	B27B-Blood whole exon sequencing data
SAMC3084421	B26B-Blood whole exon sequencing data
SAMC3084420	B24B-Blood whole exon sequencing data
SAMC3084419	B23B-Blood whole exon sequencing data
SAMC3084418	B17B-Blood whole exon sequencing data
SAMC3084417	B12B-Blood whole exon sequencing data
SAMC3084416	B8B-Blood whole exon sequencing data
SAMC3084415	B6B-Blood whole exon sequencing data
SAMC3084414	B4B-Blood whole exon sequencing data
SAMC3084413	B2B-Blood whole exon sequencing data
GSA-Human (1)	-
HRA005516	A Proteogenomic Analysis of Cervical Cancer in East Asia Reveals Biological Insights and Therapeutic Signatures
OMIX (1)	-
OMIX004882	A Proteogenomic Analysis of Cervical Cancer in East Asia Reveals Biological Insights and Therapeutic Signatures

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