| Accession | SAMC3447524 |
|---|---|
| Accession in Other Database | GSA-Human: HRS1186765 |
| Sample name | NPC_SC1805-BCR-T |
| Title | Tumor for BCR |
| Sample type | Human sample |
| Organism | Homo sapiens |
| Description | NPC single cell RNA-seq |
| Attributes | *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA006885 in the GSA-Human system. |
| Release date | 2024-07-01 |
| BioProject Accession | PRJCA009213 |
| Submitter | JINXIN BEI (beijx@sysucc.org.cn) |
| Organization | Sun Yat-sen University Cancer Center |
| Submission date | 2024-03-18 |
| Resource name | Description |
|---|---|
| GSA-Human (1) | - |
| HRA006885 (Controlled Access) | Here, we revealed the composition of TLSs in NPC, by analysing the single-cell and spatial transcriptional profiles. We identified TLS-associated cell subpopulations (germinal centre B, CD4+ T follicular helper, CXCL13+TCF7+CD8+ T cells, and CXCL13+ fibroblasts) in NPC. Moreover, TLS-associated signatures predicted better prognosis and were correlated with immunotherapy outcomes in independent NPC cohorts. |