e.g., HRA000087; HRA000150
HRA006885
Title:
Single-Cell and Spatial Analyses Reveal Tertiary Lymphoid Structures Linked to Tumour Progression and Immunotherapy Response in Nasopharyngeal Carcinoma
Release date:
2024-07-01
Description:
Here, we revealed the composition of TLSs in NPC, by analysing the single-cell and spatial transcriptional profiles. We identified TLS-associated cell subpopulations (germinal centre B, CD4+ T follicular helper, CXCL13+TCF7+CD8+ T cells, and CXCL13+ fibroblasts) in NPC. Moreover, TLS-associated signatures predicted better prognosis and were correlated with immunotherapy outcomes in independent NPC cohorts.
Data Accessibility:   
Controlled access Request Data
BioProject:
Study type:
Disease Study
Disease name:
nasopharynx carcinoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
DAC name:
BEL_LAB
Contact person:
BEI JINXIN
Email:
beijx@sysucc.org.cn
Description:
SYSUCC
Individuals & samples
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
HRI929925P02maleHRS1186763NPC_SC1802-BCR-TNPC single cell RNA-seq
HRI929925P02maleHRS1186764NPC_SC1802-BCR-BNPC single cell RNA-seq
HRI929926P05maleHRS1186765NPC_SC1805-BCR-TNPC single cell RNA-seq
HRI929926P05maleHRS1186766NPC_SC1805-BCR-BNPC single cell RNA-seq
HRI929927P06maleHRS1186767NPC_SC1806-BCR-TNPC single cell RNA-seq
HRI929927P06maleHRS1186768NPC_SC1806-BCR-BNPC single cell RNA-seq
HRI929928P07maleHRS1186769NPC_SC1807-BCR-TNPC single cell RNA-seq
HRI929928P07maleHRS1186770NPC_SC1807-BCR-BNPC single cell RNA-seq
HRI929929P08maleHRS1186771NPC_SC1808-BCR-TNPC single cell RNA-seq
HRI929929P08maleHRS1186772NPC_SC1808-BCR-BNPC single cell RNA-seq
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Run accession
Files
Experiment
Experiment title
Platform
Sample
Run accession
Files
Experiment
Experiment title
Platform
Sample
HRR1659109HRR1659109_f1.fastq.gz (0.80 GB)HRX1326745NPC_SC1802-BCR-TIllumina HiSeq X TenHRS1186763 (SAMC3447522)
HRR1659109HRR1659109_r2.fastq.gz (0.92 GB)HRX1326745NPC_SC1802-BCR-TIllumina HiSeq X TenHRS1186763 (SAMC3447522)
HRR1659110HRR1659110_f1.fastq.gz (0.77 GB)HRX1326746NPC_SC1802-BCR-BIllumina HiSeq X TenHRS1186764 (SAMC3447523)
HRR1659110HRR1659110_r2.fastq.gz (0.89 GB)HRX1326746NPC_SC1802-BCR-BIllumina HiSeq X TenHRS1186764 (SAMC3447523)
HRR1659111HRR1659111_f1.fastq.gz (0.75 GB)HRX1326747NPC_SC1805-BCR-TIllumina HiSeq X TenHRS1186765 (SAMC3447524)
HRR1659111HRR1659111_r2.fastq.gz (0.87 GB)HRX1326747NPC_SC1805-BCR-TIllumina HiSeq X TenHRS1186765 (SAMC3447524)
HRR1659112HRR1659112_f1.fastq.gz (0.64 GB)HRX1326748NPC_SC1805-BCR-BIllumina HiSeq X TenHRS1186766 (SAMC3447525)
HRR1659112HRR1659112_r2.fastq.gz (0.75 GB)HRX1326748NPC_SC1805-BCR-BIllumina HiSeq X TenHRS1186766 (SAMC3447525)
HRR1659113HRR1659113_f1.fastq.gz (1.00 GB)HRX1326749NPC_SC1806-BCR-TIllumina HiSeq X TenHRS1186767 (SAMC3447526)
HRR1659113HRR1659113_r2.fastq.gz (1.15 GB)HRX1326749NPC_SC1806-BCR-TIllumina HiSeq X TenHRS1186767 (SAMC3447526)
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Submitter:   BEI JINXIN / beijx@sysucc.org.cn
Organization:   Sun Yat-sen University Cancer Center
Submission date:   2022-04-12
Requests:   10