Cardiovascular Disease Atlas
Data release 1.0
| Disease | Stroke |
|---|---|
| CVD Atlas ID | CVDD000144 |
| MeSH ID | D020521 |
| Ontology ID | NCIT:C3390 |
| Description [MeSH] | A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) |
| Dataset | Reported disease | Tissue/cell type | Omics | Data accession |
|---|---|---|---|---|
| CVDS000304 | Vascular/heart problems diagnosed by doctor: Stroke (UKB data field 6150_3) | - | Genomics | GCST90044350 |
| CVDS000206 | Stroke (UKB data field 6150) | - | Genomics | GCST90079444 |
| CVDS000091 | Stroke | - | Genomics | GCST90104534 |
| CVDS000096 | Stroke | - | Genomics | GCST90104539 |
| CVDS000101 | Stroke | - | Genomics | GCST90104544 |
| Variant | Gene | Beta | Standard error | P value | Odds ratio | Study | Ancestry | Link |
|---|
| Gene | Tissue | Best coloc SNP | GWAS risk SNP | SNP.PP.H4 | PP.H4.abf | Ancestry | Dataset |
|---|
| Variant | Gene | Description | PMID |
|---|
| Variant | Pre miRNA | Region | Mature miRNA |
ΔG
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Predict
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PMID |
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| SNP | Reported disease | Gene | Description | PMID |
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| Reported disease | Gene | Category | Description | Publication |
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| Tissue/cell type | Gene | Reported disease | Alteration | log2FC | P value | Adjusted P value | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| No data available in table | ||||||||
| Tissue/cell type | Gene | Reported disease | Mapped disease | log2FC | P value | Adjusted P value | Method | Dataset |
|---|---|---|---|---|---|---|---|---|
| Blood | CD177 | Stroke | Stroke | 4.33 | 2.11e-5 | 4.95e-3 | RNA-seq | CVDS000592 |
| Blood | PGA4 | Stroke | Stroke | 4.20 | 3.53e-7 | 4.79e-4 | RNA-seq | CVDS000592 |
| Blood | TCL1B | Stroke | Stroke | 3.29 | 3.59e-4 | 3.20e-2 | RNA-seq | CVDS000592 |
| Blood | C2orf27A | Stroke | Stroke | 2.95 | 3.20e-6 | 1.76e-3 | RNA-seq | CVDS000592 |
| Blood | SFRP2 | Stroke | Stroke | 2.59 | 2.41e-6 | 1.66e-3 | RNA-seq | CVDS000592 |
| Blood | TEK | Stroke | Stroke | 2.33 | 9.27e-5 | 1.51e-2 | RNA-seq | CVDS000592 |
| Blood | RPS26 | Stroke | Stroke | 2.33 | 4.21e-5 | 8.03e-3 | RNA-seq | CVDS000592 |
| Blood | LINC00664 | Stroke | Stroke | 2.32 | 2.60e-4 | 2.66e-2 | RNA-seq | CVDS000592 |
| Blood | LINC02772 | Stroke | Stroke | 2.19 | 2.48e-5 | 5.57e-3 | RNA-seq | CVDS000592 |
| Blood | ENSG00000268713 | Stroke | Stroke | 2.13 | 3.37e-4 | 3.06e-2 | RNA-seq | CVDS000592 |
| Gene | Gene type | Species | Reported disease | Score | PMID | Gene link |
|---|
| Reported disease | Tissue | Gene | Effect size | P value | Method | Publication | PMID | Gene link |
|---|---|---|---|---|---|---|---|---|
| Stroke | Adipose | LRCH1 | -4.81 | 1.54e-06 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Stroke | Adipose | PLEKHA1 | 4.23 | 2.39e-05 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Stroke | Adipose | SLC25A44 | 6.21 | 5.46e-10 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Stroke | Peripheral Blood | ZNF318 | 3.97 | 7.04e-05 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Stroke | Adipose | CD40 | -3.95 | 7.67e-05 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Stroke | Adipose | FES | -3.94 | 8.06e-05 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Stroke | Peripheral Blood | RERE | 3.9 | 9.77e-05 | FUSION | TWASP000034 | 31392102 | TWAS Atlas |
| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| Stroke | MIR21 | circulation_biomarker_diagnosis_ns | The increase in miR-21a-5p secretion may have biomarker potential, as high blood levels of miR5p in stroke patients were associated with significant disability at hospital discharge. | 36594832 |
| Stroke | hsa-mir-181c | circulation_biomarker_diagnosis_up | CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS. | 36212996 |
| Stroke | MIR25 | genetics_knock down_suppress | * miR-25 inhibits loss of neurons and provides neuronal recovery in animal model of stroke via inhibiting HDAC3 and ATXN3. | 35025075 |
| Stroke | hsa-mir-374a | genetics_knock down_suppress | Knockdown of NEAT1 regulated OGD/R injury of CHME5 cells via miR374a5p/NFAT5 axis to induce the shifting of microglia from M1 to M2 and inhibit inflammatory response, making it a potential target for stroke treatment. | 35014985 |
| Stroke | hsa-mir-4292 | circulation_biomarker_diagnosis_up | After adjusting for potential confounders, we found plasma levels of 3 miRNAs to be associated with incident stroke (false discovery rate-adjusted P<0.05). These include miR-6124 (hazard ratio, 1.66 [95% CI, 1.31-2.09]), miR-5196-5p (hazard ratio, 1.90 [95% CI, 1.39-2.61]), and miR-4292 (hazard ratio, 2.65 [95% CI, 1.62-4.34]). | 33563011 |
| Stroke | MIR6124 | circulation_biomarker_diagnosis_up | After adjusting for potential confounders, we found plasma levels of 3 miRNAs to be associated with incident stroke (false discovery rate-adjusted P<0.05). These include miR-6124 (hazard ratio, 1.66 [95% CI, 1.31-2.09]), miR-5196-5p (hazard ratio, 1.90 [95% CI, 1.39-2.61]), and miR-4292 (hazard ratio, 2.65 [95% CI, 1.62-4.34]). | 33563011 |
| Stroke | hsa-mir-5196 | circulation_biomarker_diagnosis_up | After adjusting for potential confounders, we found plasma levels of 3 miRNAs to be associated with incident stroke (false discovery rate-adjusted P<0.05). These include miR-6124 (hazard ratio, 1.66 [95% CI, 1.31-2.09]), miR-5196-5p (hazard ratio, 1.90 [95% CI, 1.39-2.61]), and miR-4292 (hazard ratio, 2.65 [95% CI, 1.62-4.34]). | 33563011 |
| Stroke | hsa-mir-134 | genetics_overexpression_suppress | Our present study reported that HIF-1alpha overexpression protected PC12 cells against OGD/R-evoked injury via down-regulation of miR-134, which making HIF-1alpha and miR-134 to be promising targets for cerebral stroke therapy. | 32266863 |
| Stroke | MIR15A | circulation_biomarker_diagnosis_up | Endothelium-targeted deletion of the miR-15a/16-1 cluster also enhances post-stroke angiogenesis by promoting vascular remodeling and stimulating the generation of newly formed functional vessels, and increases the ipsilateral cerebral blood flow. | 32131693 |
| Stroke | MIR340 | circulation_biomarker_diagnosis_up | 5p), a suppressor of certain target genes in brain, reportedly is decreased in peripheral circulation of acute stroke patients. | 31870893 |
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| Stroke | mmu-miR-124 | Mus musculus | Ectopic miR-124 expression, therefore, appears as an attractive and novel tool in stroke treatment, mediating neuroprotection via a hitherto unknown mechanism that involves Usp14-dependent REST degradation | 23754622 |
| Name | Gene | Relation to gene | Tissue | Reported disease | Delta beta | P value | Adjusted P value | Dataset | GEO accession |
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| Name | Gene | Relation to gene | Reported disease | Delta beta | P value | Adjusted P value | Tissue | PMID |
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| Reported disease | Gene | Category | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Reported disease | Gene | Species | Description | Publication |
|---|---|---|---|---|
| No data available in table | ||||
| Gene | Protein | Average log2FC | P value | Dataset |
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| Metabolite | VIP | Dataset |
|---|---|---|
| No data available in table | ||
| Chemical name | Chemical ID | Direct evidence | Reported disease | Inference gene | Inference score | #PMIDs | Gene link |
|---|