| URL: | https://awi.cuhk.edu.cn/~MethHC/methhc_2020/php/index.php |
| Full name: | A database of DNA Methylation and gene expression in Human Cancer |
| Description: | The human pan-cancer methylation database, MethHC is a web based resource focused on the DNA methylation of human diseases. MethHC integrated data such as DNA methylation, gene expression, microRNA methylation, microRNA expression, and the correlation of methylation and gene expression from TCGA (The Cancer Genome Atlas) |
| Year founded: | 2015 |
| Last update: | 2020 |
| Version: | v2.0 |
| Accessibility: | |
| Country/Region: | China |
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| University/Institution: | National Chiao Tung University |
| Address: | Hsin-Chu 300,Taiwan |
| City: | Hsin-Chu |
| Province/State: | Taiwan |
| Country/Region: | China |
| Contact name (PI/Team): | Hsien-Da Huang |
| Contact email (PI/Helpdesk): | bryan@mail.nctu.edu.tw |
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MethHC 2.0: information repository of DNA methylation and gene expression in human cancer. [PMID: 33270889]
DNA methylation is an important epigenetic regulator in gene expression and has several roles in cancer and disease progression. MethHC version 2.0 (MethHC 2.0) is an integrated and web-based resource focusing on the aberrant methylomes of human diseases, specifically cancer. This paper presents an updated implementation of MethHC 2.0 by incorporating additional DNA methylomes and transcriptomes from several public repositories, including 33 human cancers, over 50 118 microarray and RNA sequencing data from TCGA and GEO, and accumulating up to 3586 manually curated data from >7000 collected published literature with experimental evidence. MethHC 2.0 has also been equipped with enhanced data annotation functionality and a user-friendly web interface for data presentation, search, and visualization. Provided features include clinical-pathological data, mutation and copy number variation, multiplicity of information (gene regions, enhancer regions, and CGI regions), and circulating tumor DNA methylation profiles, available for research such as biomarker panel design, cancer comparison, diagnosis, prognosis, therapy study and identifying potential epigenetic biomarkers. MethHC 2.0 is now available at http://awi.cuhk.edu.cn/∼MethHC. |
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MethHC: a database of DNA methylation and gene expression in human cancer. [PMID: 25398901]
We present MethHC (http://MethHC.mbc.nctu.edu.tw), a database comprising a systematic integration of a large collection of DNA methylation data and mRNA/microRNA expression profiles in human cancer. DNA methylation is an important epigenetic regulator of gene transcription, and genes with high levels of DNA methylation in their promoter regions are transcriptionally silent. Increasing numbers of DNA methylation and mRNA/microRNA expression profiles are being published in different public repositories. These data can help researchers to identify epigenetic patterns that are important for carcinogenesis. MethHC integrates data such as DNA methylation, mRNA expression, DNA methylation of microRNA gene and microRNA expression to identify correlations between DNA methylation and mRNA/microRNA expression from TCGA (The Cancer Genome Atlas), which includes 18 human cancers in more than 6000 samples, 6548 microarrays and 12 567 RNA sequencing data. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research. |