a catalog of biological databases
|Full name:||A database of DNA Methylation and gene expression in Human Cancer|
|Description:||The human pan-cancer methylation database, MethHC is a web based resource focused on the DNA methylation of human diseases. MethHC integrated data such as DNA methylation, gene expression, microRNA methylation, microRNA expression, and the correlation of methylation and gene expression from TCGA (The Cancer Genome Atlas)|
|University/Institution:||National Chiao Tung University|
|Contact name (PI/Team):||Hsien-Da Huang|
|Contact email (PI/Helpdesk):||email@example.com|
MethHC: a database of DNA methylation and gene expression in human cancer. [PMID: 25398901]
We present MethHC (http://MethHC.mbc.nctu.edu.tw), a database comprising a systematic integration of a large collection of DNA methylation data and mRNA/microRNA expression profiles in human cancer. DNA methylation is an important epigenetic regulator of gene transcription, and genes with high levels of DNA methylation in their promoter regions are transcriptionally silent. Increasing numbers of DNA methylation and mRNA/microRNA expression profiles are being published in different public repositories. These data can help researchers to identify epigenetic patterns that are important for carcinogenesis. MethHC integrates data such as DNA methylation, mRNA expression, DNA methylation of microRNA gene and microRNA expression to identify correlations between DNA methylation and mRNA/microRNA expression from TCGA (The Cancer Genome Atlas), which includes 18 human cancers in more than 6000 samples, 6548 microarrays and 12 567 RNA sequencing data. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.