Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: http://jjwanglab.org/dbpshp
Full name: Database of Positive Selection across Human Populations
Description: dbPSHP collects putative positively selected loci in human evolution and help researchers to discover the mechanism governing these natural selections.
Year founded: 2013
Last update: NA
Version: v1.0
Accessibility:
Manual:
Accessible
Real time : Checking...
Country/Region: China
Data type:
DNA
Data object:
Database category:
Major organism:
Keywords:

Contact information

University/Institution: The University of Hong Kong
Address: Department of Biochemistry,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong SAR,China
City: Hong Kong
Province/State: Hong Kong
Country/Region: China
Contact name (PI/Team): Junwen Wang
Contact email (PI/Helpdesk): junwen@hku.hk

Publications

24194603
dbPSHP: a database of recent positive selection across human populations. [PMID: 24194603]
Li MJ, Wang LY, Xia Z, Wong MP, Sham PC, Wang J.

The dbPSHP database (http://jjwanglab.org/dbpshp) aims to help researchers to efficiently identify, validate and visualize putative positively selected loci in human evolution and further discover the mechanism governing these natural selections. Recent evolution of human populations at the genomic level reflects the adaptations to the living environments, including climate change and availability and stability of nutrients. Many genetic regions under positive selection have been identified, which assist us to understand how natural selection has shaped population differences. Here, we manually collect recent positive selections in different human populations, consisting of 15,472 loci from 132 publications. We further compiled a database that used 15 statistical terms of different evolutionary attributes for single nucleotide variant sites from the HapMap 3 and 1000 Genomes Project to identify putative regions under positive selection. These attributes include variant allele/genotype properties, variant heterozygosity, within population diversity, long-range haplotypes, pairwise population differentiation and evolutionary conservation. We also provide interactive pages for visualization and annotation of different selective signals. The database is freely available to the public and will be frequently updated.

Nucleic Acids Res. 2014:42(Database issue) | 27 Citations (from Europe PMC, 2021-06-19)

Ranking

All databases:
1820/5061 (64.058%)
1820
Total Rank
27
Citations
3.857
z-index

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Record metadata

Created on: 2015-06-20
Curated by:
Zhang Zhang [2016-04-26]
Jian Sang [2016-04-04]
Jian Sang [2015-12-01]
Jian Sang [2015-06-26]