| URL: | http://patho.phenomebrowser.net |
| Full name: | A database of pathogens and their phenotypes for diagnostic support in infections |
| Description: | PathoPhenoDB aims to support diagnosis of infectious diseases caused by known pathogens. The database relies on the pathogen-to-phenotype associations. Pathogen-disease relations are linked to disease-phenotypes by using text mining methods. |
| Year founded: | 2019 |
| Last update: | |
| Version: | |
| Accessibility: |
Accessible
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| Country/Region: | Saudi Arabia |
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| Data object: | |
| Database category: | |
| Major species: |
NA
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| Keywords: |
| University/Institution: | King Abdullah University of Science and Technology |
| Address: | Computer, Electrical and Mathematical Sciences & Engineering with Division, Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, 23955, Saudi Arabia |
| City: | |
| Province/State: | |
| Country/Region: | Saudi Arabia |
| Contact name (PI/Team): | Hoehndorf R |
| Contact email (PI/Helpdesk): | robert.hoehndorf@kaust.edu.sa |
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PathoPhenoDB, linking human pathogens to their phenotypes in support of infectious disease research. [PMID: 31160594]
Understanding the relationship between the pathophysiology of infectious disease, the biology of the causative agent and the development of therapeutic and diagnostic approaches is dependent on the synthesis of a wide range of types of information. Provision of a comprehensive and integrated disease phenotype knowledgebase has the potential to provide novel and orthogonal sources of information for the understanding of infectious agent pathogenesis, and support for research on disease mechanisms. We have developed PathoPhenoDB, a database containing pathogen-to-phenotype associations. PathoPhenoDB relies on manual curation of pathogen-disease relations, on ontology-based text mining as well as manual curation to associate host disease phenotypes with infectious agents. Using Semantic Web technologies, PathoPhenoDB also links to knowledge about drug resistance mechanisms and drugs used in the treatment of infectious diseases. PathoPhenoDB is accessible at http://patho.phenomebrowser.net/ , and the data are freely available through a public SPARQL endpoint. |