Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

Full name: Internal ribosome entry sites
Description: A Comprehensive Database of Experimentally Validated Internal Ribosome Entry Sites.
Year founded: 2020
Last update: 2020-04-01
Real time : Checking...
Country/Region: China
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Contact information

University/Institution: Nanjing University of Aeronautics and Astronautics
Address: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China
City: Nanjing
Province/State: Jiangsu
Country/Region: China
Contact name (PI/Team): Xiaofeng Song
Contact email (PI/Helpdesk):


IRESbase: A Comprehensive Database of Experimentally Validated Internal Ribosome Entry Sites. [PMID: 32512182]
Jian Zhao, Yan Li, Cong Wang, Haotian Zhang, Hao Zhang, Bin Jiang, Xuejiang Guo, Xiaofeng Song

Internal ribosome entry sites (IRESs) are functional RNA elements that can directly recruit ribosomes to an internal position of the mRNA in a cap-independent manner to initiate translation. Recently, IRES elements have attracted much attention for their critical roles in various processes including translation initiation of a new type of RNA, circular RNA (circRNA), with no 5' cap to support classical cap-dependent translation. Thus, an integrative data resource of IRES elements with experimental evidence will be useful for further studies. In this study, we present IRESbase, a comprehensive database of IRESs, by curating the experimentally validated functional minimal IRES elements from literature and annotating their host linear and circular RNAs. The current version of IRESbase contains 1328 IRESs, including 774 eukaryotic IRESs and 554 viral IRESs from 11 eukaryotic organisms and 198 viruses, respectively. As IRESbase collects only IRES of minimal length with functional evidence, the median length of IRESs in IRESbase is 174 nucleotides. By mapping IRESs to human circRNAs and long non-coding RNAs (lncRNAs), 2191 circRNAs and 168 lncRNAs were found to contain at least one entire or partial IRES sequence. IRESbase is available at

Genomics Proteomics Bioinformatics. 2020:() | 5 Citations (from Europe PMC, 2021-06-19)


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122/384 (68.49%)
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Created on: 2020-11-11
Curated by:
lin liu [2021-02-19]
Zhao Li [2020-11-23]
Ming Chen [2020-11-11]