CeDR Atlas: a knowledgebase of cellular drug response.
CeDR represents an omnibus systematic exploration of tissue cell type specific drug response for human, mouse and cell lines. We collected the fast-growing single-cell transcriptome profiling generated by multiple international consortiums (e.g Single Cell Portal, Human Cell Landscape, and Mouse Cell Atlas) and other available labeled datasets to conduct the tissue cell type specific drug response analysis. CeDR provides direct references for cellular drug response profiles including not only disease cell types but also normal cell types. Currently, CeDR maintains the results for more than 582 single cell data objects for human, mouse and cell lines, including about 140 phenotypes and 1250 tissue-cell combination types, which result about 188,157 for human, 42,660 for mouse and 10,299 for cell line significant cell type-drug associations (enriched p-values<0.05, correlation p-value<0.01). Users can browse and search the drugs, cell types, tissues, and diseases and could also filter and prioritize the associations with exact gene signatures. Overall, CeDR infers drug response at cellular resolution and sheds light on the design of combinatory treatments and identification of drug resistance and even drug side effects.