Database Commons

a catalog of biological databases

e.g., animal; RNA; Methylation; China

Database Profile

General information

URL: https://ngdc.cncb.ac.cn/brainbase
Full name: a curated knowledgebase for brain diseases
Description: BrainBase integrates not only valuable knowledge associations curated from published literatures but also comprehensive molecular profiles, particularly for glioma, through multi-omics data analysis. Thus, it bears great promise to serve as a valuable knowledgebase for brain studies.
Year founded: 2020
Last update: 2021
Version: v1
Accessibility:
Manual:
Accessible
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Country/Region: China

Classification and Labelling

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Contact information

University/Institution: Beijing Institute of Genomics, Chinese Academy of Sciences
Address: National Genomics Data Center China National Center for Bioinformation / Beijing Institute of Genomics Chinese Academy of Sciences No.1 Beichen West Road Chaoyang District, Beijing 100101 China
City: Beijing
Province/State: Beijing
Country/Region: China
Contact name (PI/Team): Zhang Zhang
Contact email (PI/Helpdesk): zhangzhang@big.ac.cn

Publications

34718720
BrainBase: a curated knowledgebase for brain diseases. [PMID: 34718720]
Liu L, Zhang Y, Niu G, Li Q, Li Z, Zhu T, Feng C, Liu X, Zhang Y, Xu T, Chen R, Teng X, Zhang R, Zou D, Ma L, Zhang Z.

Brain is the central organ of the nervous system and any brain disease can seriously affect human health. Here we present BrainBase (https://ngdc.cncb.ac.cn/brainbase), a curated knowledgebase for brain diseases that aims to provide a whole picture of brain diseases and associated genes. Specifically, based on manual curation of 2768 published articles along with information retrieval from several public databases, BrainBase features comprehensive collection of 7175 disease-gene associations spanning a total of 123 brain diseases and linking with 5662 genes, 16 591 drug-target interactions covering 2118 drugs/chemicals and 623 genes, and five types of specific genes in light of expression specificity in brain tissue/regions/cerebrospinal fluid/cells. In addition, considering the severity of glioma among brain tumors, the current version of BrainBase incorporates 21 multi-omics datasets, presents molecular profiles across various samples/conditions and identifies four groups of glioma featured genes with potential clinical significance. Collectively, BrainBase integrates not only valuable curated disease-gene associations and drug-target interactions but also molecular profiles through multi-omics data analysis, accordingly bearing great promise to serve as a valuable knowledgebase for brain diseases.

Nucleic Acids Res. 2022:50(D1) | 1 Citations (from Europe PMC, 2022-05-14)

Ranking

All databases:
3848/5177 (25.691%)
Expression:
744/989 (24.874%)
Modification:
208/251 (17.53%)
Interaction:
616/829 (25.814%)
Pathway:
253/360 (30%)
Health and medicine:
823/1164 (29.381%)
Literature:
298/435 (31.724%)
3848
Total Rank
1
Citations
1
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Record metadata

Created on: 2021-09-15
Curated by:
Zhang Zhang [2022-01-29]
Yang Zhang [2021-11-11]
lin liu [2021-09-15]