e.g., HRA000087; HRA000150
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HRA001205
   HRA001205.xlsx
Title:
Circular RNA-encoded oncogenic E_cadherin variant promotes glioblastoma tumorigenicity(lncRNA-seq)
Release date:
2021-09-13
Description:
Herein, we report an additional activation mechanism of EGFR signalling in GBM by an undescribed secretory E-cadherin protein variant (C-E-Cad) encoded by a circular E-cadherin (circ-E-Cad) RNA through multiple-round open reading frame translation. C-E-Cad is overexpressed in GBM and promotes glioma stem cell tumorigenicity. C-E-Cad activates EGFR independent of EGF through association with the EGFR CR2 domain using a unique 14-amino-acid carboxy terminus, thereby maintaining glioma stem cell tumorigenicity. Notably, inhibition of C-E-Cad markedly enhances the antitumour activity of therapeutic anti-EGFR strategies in GBM. Our results uncover a critical role of C-E-Cad in stimulating EGFR signalling and provide a promising approach for treating EGFR-driven GBM.These were the linear depeleted sequencing data for circRNA detecttion..These were the rRNA depeleted sequencing data for mRNA and lncRNA detecttion.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005969
Study type:
Disease Study
Disease name:
mixed glioma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000783
DAC name:
Nu Zhang lab Data Access Committee
Contact person:
Zhang Nu
Email:
zhangnu2@mail.sysu.edu.cn
Description:
Control the Nu Zhang lab's data access in NGDC
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Submitter:   Zhang Nu / zhangnu2@mail.sysu.edu.cn
Organization:   Sun Yat-sen University
Submission date:   2021-08-23
Requests:   -