e.g., HRA000087; HRA000150
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HRA001206
   HRA001206.xlsx
Title:
Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab
Release date:
2021-09-07
Description:
Circular HER2 RNA (circHER2) encoded a novel protein, HER2_103. Unexpectedly, while HER2 mRNA and protein were barely detected, circ_HER2/HER2_103 was expressed in about 30% TNBC clinical samples. Circ_HER2/HER2_103 positive TNBC patients harbored worse overall prognosis than circ_HER2/HER2_103 negative patients.Knockdown circ_HER2 inhibited TNBC cells proliferation, invasion and tumorigenesis in vitro and in vivo, suggesting the critical role of circ_HER2/HER2_103 in TNBC tumorigenicity. Mechanistically, HER2_103 promoted homo/hetero dimerization of epidermal growth factor receptor (EGFR)/HER3, sustained AKT phosphorylation and downstream malignant phenotypes. Furthermore, HER2_103 shared most of the same amino acid sequences as HER2 CR1 domain which could be antagonized by Pertuzumab, a clinical used HER2 antibody. Pertuzumab markedly attenuated in vivo tumorigenicity of circ_HER2/HER2_103 expressing TNBC cells but showed no effects in circ_HER2/HER2_103 negative TNBC cells.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005969
Study type:
Disease Study
Disease name:
triple-receptor negative breast cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000783
DAC name:
Nu Zhang lab Data Access Committee
Contact person:
Zhang Nu
Email:
zhangnu2@mail.sysu.edu.cn
Description:
Control the Nu Zhang lab's data access in NGDC
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Submitter:   Zhang Nu / zhangnu2@mail.sysu.edu.cn
Organization:   Sun Yat-sen University
Submission date:   2021-08-23
Requests:   1