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HRA001248
   HRA001248.xlsx
Title:
Polymorphisms and haplotype of mitochondrial DNA D-loop region are associated with polycystic ovary syndrome in a Chinese population
Release date:
2021-09-23
Description:
Polymorphisms in mitochondrial DNA (mtDNA) have been linked to a range of diseases. Here we investigate the relationship between mtDNA D-loop region polymorphisms, mtDNA haplotype and polycystic ovary syndrome (PCOS), as well as the correlation of D-loop variants and clinical characteristics of PCOS, in a Chinese population. The mtDNA D-loop of whole blood samples from 421 PCOS patients and 409 controls underwent next generation sequencing. The variants G207A, 16036GGins and 16049Gins were associated with decreased risk of PCOS. No variants were associated with PCOS, and within the PCOS group, no statistical significance was found between D-loop polymorphisms and clinical characteristics. Patient haplotype was identified from D-loop single nucleotide polymorphisms and analysis suggested that haplotype A15 was significantly associated with decreased risk of PCOS. In conclusion, mtDNA D-loop alterations and haplotype appear to confer resistance to PCOS in Chinese women.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005803
Study type:
Disease Study
Disease name:
polycystic ovary syndrome
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000714
DAC name:
Dongmei Ji
Contact person:
Ji Dongmei
Email:
cahsxjdm@aliyun.com
Description:
mitochondrial research
Individuals & samples
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
Individual Accession
Individual Name
Gender
Sample Accession
Sample Name
Sample Description
HRI145504PCOS-20femaleHRS277366PCOS-20To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145505PCOS-21femaleHRS277367PCOS-21To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145506PCOS-25femaleHRS277368PCOS-25To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145507PCOS-26femaleHRS277369PCOS-26To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145508PCOS-27femaleHRS277370PCOS-27To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145509PCOS-29femaleHRS277371PCOS-29To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145510PCOS-31femaleHRS277372PCOS-31To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145511PCOS-37femaleHRS277373PCOS-37To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145512PCOS-38femaleHRS277374PCOS-38To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
HRI145513PCOS-39femaleHRS277375PCOS-39To investigate the relationship between polycystic ovary syndrome and mitochondrial alteration.
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Experiment
Experiment title
Platform
Sample
Run accession
Files
Experiment
Experiment title
Platform
Sample
HRR362431HRR362431.fasta.gz (0.00 GB)HRX302072PCOS-20AB 3730 Genetic AnalyzerHRS277366 (SAMC1841610)
HRR362432HRR362432.fasta.gz (0.00 GB)HRX302073PCOS-21AB 3730 Genetic AnalyzerHRS277367 (SAMC1841615)
HRR362433HRR362433.fasta.gz (0.00 GB)HRX302074PCOS-25AB 3730 Genetic AnalyzerHRS277368 (SAMC1841619)
HRR362434HRR362434.fasta.gz (0.00 GB)HRX302075PCOS-26AB 3730 Genetic AnalyzerHRS277369 (SAMC1841622)
HRR362435HRR362435.fasta.gz (0.00 GB)HRX302076PCOS-27AB 3730 Genetic AnalyzerHRS277370 (SAMC1841626)
HRR362436HRR362436.fasta.gz (0.00 GB)HRX302077PCOS-29AB 3730 Genetic AnalyzerHRS277371 (SAMC1841630)
HRR362437HRR362437.fasta.gz (0.00 GB)HRX302078PCOS-31AB 3730 Genetic AnalyzerHRS277372 (SAMC1841634)
HRR362438HRR362438.fasta.gz (0.00 GB)HRX302079PCOS-37AB 3730 Genetic AnalyzerHRS277373 (SAMC1841638)
HRR362439HRR362439.fasta.gz (0.00 GB)HRX302080PCOS-38AB 3730 Genetic AnalyzerHRS277374 (SAMC1841641)
HRR362440HRR362440.fasta.gz (0.00 GB)HRX302081PCOS-39AB 3730 Genetic AnalyzerHRS277375 (SAMC1841645)
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Submitter:   Ji Dongmei / cahsxjdm@aliyun.com
Organization:   The First Affiliated Hospital of Anhui Medical University
Submission date:   2021-07-10
Requests:   -