Disease Description: Abnormally high pressure in the eye.
Inherit Mode: Inherited open angle glaucoma is an autosomal recessive trait in beagles. Narrow angle glaucoma is inherited as an autosomal dominant trait in the Welsh springer spaniel. The mode of inheritance for glaucoma in other breeds has not been identified.
Disease Symptom: Primary open angle glaucoma develops slowly over weeks to months. With closed angle glaucoma, which is much more common, there is usually a sudden, rapid elevation in the pressure within the eye. This affects all the structures in the eye. The effects on the optic nerve and retina cause loss of vision. Glaucoma is moderately to extremely painful. The eye may be red and your dog may paw at it, or rub his or her head along the carpet. The eye may look cloudy due to swelling of the cornea and your dog will be very sensitive to light. The affected eye may seem larger, or appear to bulge out, relative to the other eye. Other more general signs of pain include loss of appetite and depression. Glaucoma is an emergency.Treatment must be started as soon as possible if your dog's sight is to be saved. Irreversible damage to the retina and optic nerve occur within a few hours of significant elevation of the intraocular pressure.
Disease Cause: -
Disease Diagnose: Glaucoma is one of the conditions your veterinarian will suspect if your dog has a painful eye. It is diagnosed by measuring the intraocular pressure with a tonometer. This can usually be done with local anaesthetic drops placed in your dog's eye. To determine the type of glaucoma, gonioscopy is used to measure the iridocorneal angle.
Treat Method: Preserving vision in an eye with glaucoma is difficult and requires aggressive medical and surgical therapy. Your veterinarian may choose to provide initial emergency medical therapy and refer you immediately to a larger veterinary centre. Treatment depends on several factors - the type of glaucoma present, the degree of elevation of IOP, and the extent of visual impairment. Primary open angle glaucoma tends to be slower in onset and may, at least initially, be controlled by medical therapy (drugs) alone. With closed angle glaucoma, which is much more common, there is usually a sudden, rapid elevation in IOP. Ultimately, most forms of glaucoma require surgery. If vision is present or has just recently been lost, a combination of medical and surgical therapy will be used to try and maintain your dog's sight . Aggressive medical therapy (meaning a combination of anti-glaucoma drugs administered frequently and monitored closely) is used to reduce IOP prior to surgery to prevent further damage to the eye. Some of these drugs will be used as well for additional minor IOP reductions following surgery. The aim of surgery in an eye that is still visual (or potentially visual) is to decrease the production of fluid within the eye, and to improve the drainage from the eye. There are a few different methods that a veterinary ophthalmologist can use to achieve this. If the eye is irretrievably blind, glaucoma can be treated by removing the globe of the eye (enucleation). This will eliminate the pain for your dog. There are also procedures that can be done that preserve the globe such as placing a prosthesis. Inherited glaucoma usually occurs in both eyes eventually. Your veterinarian will monitor the pressure in the other eye regularly, and discuss with you recognition of early signs of glaucoma. He or she may also recommend preventive medication for the unaffected eye.
Breeder Advice: Animals of predisposed breeds should be screened for glaucoma before being used for breeding. Affected dogs and their close relatives should not be bred. Unfortunately, glaucoma does not generally become apparent until after breeding age has been reached, usually 3 years of age or greater.
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Glaucoma, generic | - | - | - | ||
Glaucoma, primary open angle, ADAMTS10-related | Primary open angle glaucoma | Autosomal Recessive | ADAMTS10 | ||
Glaucoma, primary closed-angle | - | Autosomal Recessive | - | NEB | |
Glaucoma, primary open angle, ADAMTS17-related | - | Autosomal Recessive | ADAMTS17 | ||
Glaucoma, primary open angle | - | - | - | - |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB2 | Afghan Hound | Independent, sweet, silly | 63.5-68.6 cm | 22.7-27.2 kg | Afghanistan |
CB4 | Akita | Dignified, courageous, and profoundly loyal to their humans | 66-71.1 cm (male), 61-66 cm (female) | 45.4-59 kg (male), 31.8-45.4 kg (female) | Japan |
CB5 | Alaskan Malamute | Affectionate, loyal, playful but dignified | 63.5 cm (male), 58.4 cm (female) | 38.6 kg (male), 34 kg (female) | United States |
CB22 | Basset Hound | Patient and low-key; a bit stubborn but always charming | up to 38.1 cm | 18.1-29.5 kg | France |
CB23 | Bavarian Mountain Scent Hound | Loyal, Versatile, Reserved with Strangers | 17-20.5 inches | 37-66 pound | |
CB24 | English Beagle | Merry, friendly, and curious | 33 cm & under 33-38.1 cm | under 9.1 kg (5.9 inches & under), 9.1-13.6 kg (5.9-6.8 inches) | United Kingdom (England) |
CB25 | Bearded Collie | Bouncy, charismatic, friendly; smart, but also stubborn and independent | 53.3-55.9 cm (male), 50.8-53.3 cm (female) | 20.4-24.9 kg | United Kingdom (Scotland) |
CB27 | Bedlington Terrier | Rollicking, charming, and full of fun; a loyal member of the family | 40.6-44.5 cm (male), 38.1-41.9 cm (female) | 7.7-10.4 kg | United Kingdom |
CB46 | Boston Terrier | Friendly, bright, amusing, and adaptable. | 38.1-43.2 cm | 4.5-11.3 kg | United States |
CB47 | Bouvier des Flandres(Flanders Cattle Dog) | Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders | 62.2-69.9 cm (male), 59.7-67.3 cm (female) | 31.8-49.9 kg | Belgium |
CB54 | Brittany | Bright, upbeat, fun-loving at home; a tireless, enthusiastic worker afield | 44.5-52.1 cm | 13.6-18.1 kg | France |
CB60 | Cairn Terrier | Cheerful, alert, busy and independent-minded | 25.4 cm (male), 24.1 cm (female) | 6.4 kg (male), 5.9 kg (female) | United Kingdom (Scotland) |
CB61 | Canaan Dog | Alert, vigilant, territorial; docile with family, aloof with strangers | 50.8-61 cm (male), 48.3-58.4 cm (female) | 20.4-24.9 kg (male), 15.9-20.4 kg (female) | Middle East Lebanon - Israel |
CB64 | Carolina Dog | Loyal, Independent, Reserved with Strangers | 17.75-19.5 inches | 30-55 pounds | United States |
CB71 | Chihuahua | Graceful, charming, and sassy. | 15.2-22.9 cm | 1.4-2.7 kg | Mexico |
CB72 | Chinese Crested | Lively, alert, and affectionate | 27.9-33 cm | 3.6-5.4 kg | Africa, Mexico |
CB73 | Chinese Shar-Pei | Steadfastly devoted to loved ones, but standoffish and lordly toward strangers | 45.7-50.8 cm | 20.4-27.2 kg | China |
CB74 | Chinook | Patient, smart, willing to please; a devoted family dog | 61-66 cm (male), 55.9-61 cm (female) | 24.9-40.8 kg (male), 22.7-29.5 kg (female) | United States |
CB75 | Chow Chow | Serious-minded, dignified, bright, and aloof | 43.2-50.8 cm | 20.4-31.8 kg | China |
CB76 | Cirneco dell'Etna | Affectionate, Friendly, Independent | 18-19.5 inches (male), 16.5-18 inches (female) | 22-26 pounds (male), 17-22 pounds (female) | Italy |
CB78 | Cocker Spaniel | Happy, smart, gentle | 36.8-39.4 cm (male), 34.3-36.8 cm (female) | 11.3-13.6 kg (male), 9.1-11.3 kg (female) | |
CB83 | Dachshund | Friendly, Curious, Spunky | 20.3-22.9 cm (standard), 12.7-15.2 cm (miniature) | 7.3-14.5 kg (standard), 5 kg & under (miniature) | Germany |
CB84 | Dalmatian | Stable, Outgoing;Dignified but never shy | 48.3-61 cm | 20.4-31.8 kg | Croatia |
CB85 | Dandie Dinmont Terrier | Independent, proud, smart; affectionate at home, bold and tenacious in the field | 20.3-27.9 cm | 8.2-10.9 kg | United Kingdom (Scotland) |
CB86 | Danish-Swedish Farmdog | Energetic, Trainable, Attentive | 34-37cm (male), 32-35 cm (female) | 6.8-9 kg | Denmark, Sweden |
CB94 | English Cocker Spaniel | Merry and responsive, alive with energy | 40.6-43.2 cm (male), 38.1-40.6 cm (female) | 12.7-15.4 kg (male), 11.8-14.5 kg (female) | United Kingdom (England) |
CB95 | English Foxhound | Affectionate, Gentle, Sociable | 61 cm | 27.2-34 kg | United Kingdom (England) |
CB97 | English Springer Spaniel | Friendly, playful, obedient at home; hardworking and steady in the field | 50.8 cm (male), 48.3 cm (female) | 22.7 kg (male), 18.1 kg (female) | United Kingdom (England) |
CB98 | English Toy Spaniel | Affectionate, Alert, Merry | 22.9-25.4 cm | 3.6-6.4 kg | England |
CB115 | Irish Glen of Imaal Terrier | Gentler, less excitable than most terriers, but still bold and spirited | 31.8-35.6 cm | 14.5-18.1 kg | Ireland |
CB119 | Great Dane | Friendly, patient, & dependable. | 76.2-86.4 cm (male), 71.1-81.3 cm (female) | 54.4-90.7 kg (male), 44.9-59 kg (female) | Germany |
CB120 | Great Pyrenees | Calm, patient, smart; strong-willed yet affectionate | 68.6-81.3 cm (male), 63.5-73.7 cm (female) | 45.4 kg & up (male), 38.6 kg & up (female) | France, Spain |
CB136 | German Jagdterrier | Courageous, Intelligent, Hardworking | 33-40cm | 7.7-9.9kg | Germany |
CB141 | Keeshond | Outgoing, lively, friendly to all; a lover, not a fighter | 45.7 cm (male), 43.2 cm (female) | 15.9-20.4 kg | Netherlands, Germany |
CB142 | Irish Blue Terrier | Smart and alert; people oriented, with a dash of Irish humor in his heart | 45.7-49.5 cm (male), 44.5-48.3 cm (female) | 15-18.1 kg (male), females weigh slightly less than males | Ireland |
CB155 | Maltese | Gentle, playful, affectionate; fearless in a charming toy-dog way. | 20.3-25.4 cm | 2.7-3.6 kg | Italy |
CB156 | Manchester Terrier | Spirited, bright, keenly observant; dead loyal, in an independent terrier way | 38.1-40.6 cm | 5.4-10 kg (standard) | United Kingdom (England) |
CB161 | Miniature Schnauzer | Friendly, smart, obedient | 30.5-35.6 cm | 5-9.1 kg | Germany |
CB167 | Norfolk Terrier | Alert, fearless, fun-loving, and more sociable than the usual terrier | 22.9-25.4 cm | 5-5.4 kg | United Kingdom |
CB170 | Norwegian Elkhound | Confident, dependable; dignified but friendly | 52.1 cm (male), 49.5 cm (female) | 24.9 kg (male), 21.8 kg (female) | Norway |
CB171 | Norwegian Lundehund | Loving and loyal, also brave, tenacious, and a bit stubborn | 33-38.1 cm (male), 30.5-35.6 cm (female) | 9.1-13.6 kg | Norway |
CB209 | Saluki | Gentle, dignified, loyal but independent-minded | 58.4-71.1 cm (male), considerably smaller (female) | 18.1-29.5 kg | Fertile Crescent |
CB210 | Samoyed | Gentle, adaptable, eager, friendly; conservative but never shy | 53.3-59.7 cm (male), 48.3-53.3 cm (female) | 20.4-29.5 kg (male), 15.9-22.7 kg (female) | Russia |
CB211 | Schapendoes | Friendly, high spirited, and affectionate | Netherlands | ||
CB215 | Sealyham Terrier | Alert and outgoing; stubbornness is tempered by a sly sense of humor | 26.7 cm | 10.4-10.9 kg (male), slightly less (females) | United Kingdom (Wales) |
CB216 | Shetland Shepherd Dog | Bright, playful, and energetic | 33-40.6 cm | 6.8-11.3 kg | United Kingdom (Scotland) |
CB220 | Siberian Husky | Friendly, gentle, dignified; alert, but not aggressive. | 53.3-61 cm (male), 50.8-55.9 cm (female) | 20-27.2 kg (male), 15.9-23.1 kg (female) | Russia |
CB221 | Silky Terrier | Friendly, vivacious, cheeky; in all ways a true terrier | 22.9-25.4 cm | around 4.5 kg | Australia |
CB227 | Smooth Fox Terrier | Friendly and family oriented; bright enough to have a mind of their own | Not exceeding 39 cm in dogs, bitches slightly less. | Dogs: 7,5 - 8 kgs.Bitches: 7 - 7,5 kgs | United Kingdom (England) |
CB228 | Soft-Coated Wheaten Terrier | Happy, friendly, and deeply devoted; just stubborn enough to remind you they’re terriers | 45.7-48.3 cm (male), 43.2-45.7 cm (female) | 15.9-18.1 kg (male), 13.6-15.9 kg (female) | Ireland |
CB253 | Welsh Springer Spaniel | Happy, upbeat, family oriented; reserved but not shy with strangers | 45.7-48.3 cm (male), 43.2-45.7 cm (female) | 18.1-24.9 kg (male), 15.9-22.7 kg (female) | United Kingdom (Wales) |
CB254 | Welsh Terrier | As alert and spirited as any self-respecting terrier, but a bit calmer than most | 38.1 cm (male), porportionally smaller (female) | 9.1 kg, porportionally smaller (female) | United Kingdom (Wales) |
CB255 | West Highland White Terrier | Happy, smart, loyal, entertaining | 27.9 cm (male). 25.4 cm, female | 6.8-9.1 kg | United Kingdom (Scotland) |
CB257 | Wire-Haired Fox Terrier | Alert, quick of movement, keen of expression, on tiptoe of expectation at slightest provocation. Friendly, forthcoming and fearless. | 39 cm | 8.25 kg | United Kingdom (England) |
CB258 | Wire-Haired Pointing Griffon | Outgoing, eager, quick-minded; trustworthy in the field and around the house | Netherlands, France | ||
CB268 | Miniature Poodle | Intelligent, Eager-to-please , Charming companion | 25-38 cm | 4.5-6.8kg | France&Germany |
CB269 | Standard Poodle | Intelligent and quick-to-please | 56-66 cm | ||
CB270 | Toy Poodle | Intelligent, eager to please, quick to learn and an affectionate, loyal pet. | under 25 cm |
2019 |
Oliver,J.A.C.,Ricketts,S.L.,Kuehn,M.H.,Mellersh,C.S.: :
Primary closed angle glaucoma in the Basset Hound: Genetic investigations using genome-wide association and RNA sequencing strategies. Mol Vis 25:93-105, 2019. Pubmed reference: 30820145 . |
2019 |
Jeanes,E.C.,Oliver,J.A.C.,Ricketts,S.L.,Gould,D.J.,Mellersh,C.S.: :
Glaucoma-causing <i>ADAMTS17</i> mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma. Canine Genet Epidemiol 6:5, 2019. Pubmed reference: 31131111 . DOI: 10.1186/s40575-019-0071-6 . |
2019 |
Park,S.A.,Sledge,D.,Monahan,C.,Bartoe,J.T.,Komáromy,A.M.: :
Primary angle-closure glaucoma with goniodysgenesis in a Beagle dog. BMC Vet Res 15:75, 2019. Pubmed reference: 30832652 . DOI: 10.1186/s12917-019-1812-1 . |
2018 |
Oliver,J.A.C.,Rustidge,S.,Pettitt,L.,Jenkins,C.A.,Farias,F.H.G.,Giuliano,E.A.,Mellersh,C.S.: :
Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res 79:98-106, 2018. Pubmed reference: 29287154 . DOI: 10.2460/ajvr.79.1.98 . |
2017 |
Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 . |
2017 |
Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 . |
2017 |
Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 . |
2017 |
Bedford,P.G.: :
Open-angle glaucoma in the Petit Basset Griffon Vendeen. Vet Ophthalmol 20:98-102, 2017. Pubmed reference: 26945802 . DOI: 10.1111/vop.12369 . |
2017 |
Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 . |
2017 |
Graham,K.L.,McCowan,C.,White,A.: :
Genetic and Biochemical Biomarkers in Canine Glaucoma. Vet Pathol 54:194-203, 2017. Pubmed reference: 27681326 . DOI: 10.1177/0300985816666611 . |
2016 |
Oliver,J.A.,Ekiri,A.,Mellersh,C.S.: :
Prevalence of pectinate ligament dysplasia and associations with age, sex and intraocular pressure in the Basset hound, Flatcoated retriever and Dandie Dinmont terrier. Canine Genet Epidemiol 3:1, 2016. Pubmed reference: 26973793 . DOI: 10.1186/s40575-016-0033-1 . |
2016 |
Boote,C.,Palko,J.R.,Sorensen,T.,Mohammadvali,A.,Elsheikh,A.,Komáromy,A.M.,Pan,X.,Liu,J.: :
Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Mol Vis 22:503-17, 2016. Pubmed reference: 27212875 . |
2016 |
Palko,J.R.,Morris,H.J.,Pan,X.,Harman,C.D.,Koehl,K.L.,Gelatt,K.N.,Plummer,C.E.,Komáromy,A.M.,Liu,J.: :
Influence of Age on Ocular Biomechanical Properties in a Canine Glaucoma Model with ADAMTS10 Mutation. PLoS One 11:e0156466, 2016. Pubmed reference: 27271467 . DOI: 10.1371/journal.pone.0156466 . |
2016 |
Oliver,J.A.,Forman,O.P.,Pettitt,L.,Mellersh,C.S.: :
Correction: Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One 11:e0156192, 2016. Pubmed reference: 27192202 . DOI: 10.1371/journal.pone.0156192 . |
2015 |
Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015. Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 . |
2015 |
Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015. Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 . |
2015 |
Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015. Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 . |
2015 |
Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015. Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 . |
2015 |
Ahram,D.F.,Grozdanic,S.D.,Kecova,H.,Henkes,A.,Collin,R.W.,Kuehn,M.H.: :
Variants in Nebulin (NEB) Are Linked to the Development of Familial Primary Angle Closure Glaucoma in Basset Hounds. PLoS One 10:e0126660, 2015. Pubmed reference: 25938837 . DOI: 10.1371/journal.pone.0126660 . |
2015 |
Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015. Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 . |
2015 |
Pearl,R.,Gould,D.,Spiess,B.,Pearl,R.,Gould,D.,Spiess,B.: :
Progression of pectinate ligament dysplasia over time in two populations of Flat-Coated Retrievers. Vet Ophthalmol 18:6-12, 2015. Pubmed reference: 24025050 . DOI: 10.1111/vop.12098 . |
2015 |
Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015. Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 . |
2015 |
Forman,O.P.,Pettitt,L.,Komáromy,A.M.,Bedford,P.,Mellersh,C.: :
A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17. PLoS One 10:e0143546, 2015. Pubmed reference: 26683476 . DOI: 10.1371/journal.pone.0143546 . |
2015 |
Komáromy,A.M.,Petersen-Jones,S.M.: :
Genetics of Canine Primary Glaucomas. Vet Clin North Am Small Anim Pract 45:1159-82, v, 2015. Pubmed reference: 26277300 . DOI: 10.1016/j.cvsm.2015.06.003 . |
2015 |
Oliver,J.A.,Forman,O.P.,Pettitt,L.,Mellersh,C.S.: :
Two Independent Mutations in ADAMTS17 Are Associated with Primary Open Angle Glaucoma in the Basset Hound and Basset Fauve de Bretagne Breeds of Dog. PLoS One 10:e0140436, 2015. Pubmed reference: 26474315 . DOI: 10.1371/journal.pone.0140436 . |
2015 |
Pizzirani,S.: :
Definition, Classification, and Pathophysiology of Canine Glaucoma. Vet Clin North Am Small Anim Pract 45:1127-57, v, 2015. Pubmed reference: 26456751 . DOI: 10.1016/j.cvsm.2015.06.002 . |
2014 |
Chen,T.,Gionfriddo,J.R.,Tai,P.Y.,Novakowski,A.N.,Alyahya,K.,Madl,J.E.: :
Oxidative stress increases in retinas of dogs in acute glaucoma but not in chronic glaucoma. Vet Ophthalmol :, 2014. Pubmed reference: 24814303 . DOI: 10.1111/vop.12177 . |
2014 |
Ahonen,S.J.,Kaukonen,M.,Nussdorfer,F.D.,Harman,C.D.,Komáromy,A.M.,Lohi,H.: :
A novel missense mutation in ADAMTS10 in Norwegian Elkhound primary glaucoma. PLoS One 9:e111941, 2014. Pubmed reference: 25372548 . DOI: 10.1371/journal.pone.0111941 . |
2014 |
Ahram,D.F.,Cook,A.C.,Kecova,H.,Grozdanic,S.D.,Kuehn,M.H.: :
Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound. Mol Vis 20:497-510, 2014. Pubmed reference: 24791135 . |
2013 |
Low,M.C.,Landis,M.L.,Peiffer,R.L.: :
Intravitreal cidofovir injection for the management of chronic glaucoma in dogs. Vet Ophthalmol :, 2013. Pubmed reference: 23763487 . DOI: 10.1111/vop.12071 . |
2013 |
Pumphrey,S.A.,Pizzirani,S.,Pirie,C.G.,Anwer,M.S.,Logvinenko,T.: :
Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma. Am J Vet Res 74:621-8, 2013. Pubmed reference: 23531071 . DOI: 10.2460/ajvr.74.4.621 . |
2013 |
Wang,Q.,Grozdanic,S.D.,Harper,M.M.,Hamouche,K.,Hamouche,N.,Kecova,H.,Lazic,T.,Hernandez-Merino,E.,Yu,C.: :
Detection and characterization of glaucoma-like canine retinal tissues using Raman spectroscopy. J Biomed Opt 18:67008, 2013. Pubmed reference: 23804216 . DOI: 10.1117/1.JBO.18.6.067008 . |
2013 |
Kuchtey,J.,Kunkel,J.,Esson,D.,Sapienza,J.S.,Ward,D.A.,Plummer,C.E.,Gelatt,K.N.,Kuchtey,R.W.: :
Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in Beagles. Invest Ophthalmol Vis Sci 54:1881-6, 2013. Pubmed reference: 23422823 . DOI: 10.1167/iovs.12-10796 . |
2013 |
Palko,J.R.,Iwabe,S.,Pan,X.,Agarwal,G.,Komáromy,A.M.,Liu,J.: :
Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation. Invest Ophthalmol Vis Sci 54:2685-95, 2013. Pubmed reference: 23518772 . DOI: 10.1167/iovs.12-10621 . |
2013 |
Ahonen,S.J.,Pietilä,E.,Mellersh,C.S.,Tiira,K.,Hansen,L.,Johnson,G.S.,Lohi,H.: :
Genome-wide association study identifies a novel canine glaucoma locus. PLoS One 8:e70903, 2013. Pubmed reference: 23951034 . DOI: 10.1371/journal.pone.0070903 . |
2013 |
Kanemaki,N.,Tchedre,K.T.,Imayasu,M.,Kawarai,S.,Sakaguchi,M.,Yoshino,A.,Itoh,N.,Meguro,A.,Mizuki,N.: :
Dogs and Humans Share a Common Susceptibility Gene SRBD1 for Glaucoma Risk. PLoS One 8:e74372, 2013. Pubmed reference: 24040232 . DOI: 10.1371/journal.pone.0074372 . |
2012 |
Bouhenni,R.A.,Dunmire,J.,Sewell,A.,Edward,D.P.: :
Animal models of glaucoma. J Biomed Biotechnol 2012:692609, 2012. Pubmed reference: 22665989 . DOI: 10.1155/2012/692609 . |
2012 |
Pumphrey,S.A.,Pizzirani,S.,Pirie,C.G.,Needle,D.B.: :
Glaucoma associated with uveal cysts and goniodysgenesis in American Bulldogs: a case series. Vet Ophthalmol :, 2012. Pubmed reference: 23110479 . DOI: 10.1111/vop.12000 . |
2012 |
Kato,K.,Sasaki,N.,Shastry,B.S.: :
Retinal ganglion cell (RGC) death in glaucomatous Beagles is not associated with mutations in p53 and NTF4 genes. Vet Ophthalmol 15 Suppl 2:8-12, 2012. Pubmed reference: 22524196 . DOI: 10.1111/j.1463-5224.2012.01024.x . |
2011 |
Strom,A.R.,Hässig,M.,Iburg,T.M.,Spiess,B.M.: :
Epidemiology of canine glaucoma presented to University of Zurich from 1995 to 2009. Part 1: Congenital and primary glaucoma (4 and 123 cases). Vet Ophthalmol 14:121-6, 2011. Pubmed reference: 21366828 . DOI: 10.1111/j.1463-5224.2010.00855.x . |
2011 |
Strom,A.R.,Hässig,M.,Iburg,T.M.,Spiess,B.M.: :
Epidemiology of canine glaucoma presented to University of Zurich from 1995 to 2009. Part 2: secondary glaucoma (217 cases). Vet Ophthalmol 14:127-32, 2011. Pubmed reference: 21366829 . DOI: 10.1111/j.1463-5224.2010.00854.x . |
2011 |
Kuchtey,J.,Olson,L.M.,Rinkoski,T.,Mackay,E.O.,Iverson,T.M.,Gelatt,K.N.,Haines,J.L.,Kuchtey,R.W.: :
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS Genet 7:e1001306, 2011. Pubmed reference: 21379321 . DOI: 10.1371/journal.pgen.1001306 . |
2010 |
Grozdanic,SD.,Kecova,H.,Harper,MM.,Nilaweera,W.,Kuehn,MH.,Kardon,RH.: :
Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Invest Ophthalmol Vis Sci 51:255-63, 2010. Pubmed reference: 19661222 . DOI: 10.1167/iovs.09-4081 . |
2009 |
Dzanis,D.: :
Canine glaucoma: medical and surgical treatment options. Compend Contin Educ Vet 31:462-6, 2009. Pubmed reference: 20180215 . |
2009 |
Esson,D.,Armour,M.,Mundy,P.,Schobert,C.S.,Dubielzig,R.R.: :
The histopathological and immunohistochemical characteristics of pigmentary and cystic glaucoma in the Golden Retriever. Vet Ophthalmol 12:361-8, 2009. Pubmed reference: 19883466 . DOI: 10.1111/j.1463-5224.2009.00732.x . |
2009 |
Reinstein,S.,Rankin,A.,Allbaugh,R.: :
Canine glaucoma: medical and surgical treatment options. Compend Contin Educ Vet 31:454-60, 2009. Pubmed reference: 20180214 . |
2009 |
Reinstein,S.,Rankin,A.,Allbaugh,R.: :
Canine glaucoma: pathophysiology and diagnosis. Compend Contin Educ Vet 31:450-3, 2009. Pubmed reference: 20180213 . |
2009 |
Kato,K.,Kamida,A.,Sasaki,N.,Shastry,BS.: :
Evaluation of the CYP1B1 gene as a candidate gene in Beagles with primary open-angle glaucoma (POAG). Mol Vis 15:2470-4, 2009. Pubmed reference: 1428571 . |
2008 |
Mackay,E.O.,Källberg,M.E.,Gelatt,K.N.: :
Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles. Vet Ophthalmol 11:177-85, 2008. Pubmed reference: 18435660 . DOI: 10.1111/j.1463-5224.2008.00617.x . |
2006 |
Kato,K.,Sasaki,N.,Matsunaga,S.,Mochizuki,M.,Nishimura,R.,Ogawa,H.: :
Possible association of glaucoma with pectinate ligament dysplasia and narrowing of the iridocorneal angle in Shiba Inu dogs in Japan. Vet Ophthalmol 9:71-5, 2006. Pubmed reference: 16497230 . DOI: 10.1111/j.1463-5224.2006.00438.x . |
2005 |
Sapienza,JS.,vanderWoerdt,A.: :
Combined transscleral diode laser cyclophotocoagulation and Ahmed gonioimplantation in dogs with primary glaucoma: 51 cases (1996-2004). Vet Ophthalmol 8:121-7, 2005. Pubmed reference: 15762925 . DOI: 10.1111/j.1463-5224.2005.00356.x . |
2004 |
Gelatt,K.N.,MacKay,E.O.: :
Prevalence of the breed-related glaucomas in pure-bred dogs in North America. Vet Ophthalmol 7:97-111, 2004. Pubmed reference: 14982589 . DOI: 10.1111/j.1463-5224.2004.04006.x . |
2002 |
Bjerkas,E.,Ekesten,B.,Farstad,W.: :
Pectinate ligament dysplasia and narrowing of the iridocorneal angle associated with glaucoma in the English Springer Spaniel Veterinary Ophthalmology 5:49-54, 2002. Pubmed reference: 11940248 . |
1998 |
Read,R.A.,Wood,J.L.,Lakhani,K.H.: :
Pectinate ligament dysplasia (PLD) and glaucoma in Flat Coated Retrievers. I. Objectives, technique and results of a PLD survey. Vet Ophthalmol 1:85-90, 1998. Pubmed reference: 11397215 . |
1998 |
Wood,J.L.,Lakhani,K.H.,Read,R.A.: :
Pectinate ligament dysplasia and glaucoma in Flat Coated Retrievers. II. Assessment of prevalence and heritability. Vet Ophthalmol 1:91-99, 1998. Pubmed reference: 11397216 . |
1996 |
Ruhli,M.B.,Spiess,B.M.: :
Goniodysgenesis in the bouvier des flandres dog [German] Schweizer Archiv fur Tierheilkunde 138:307-311, 1996. Pubmed reference: 8765546 . |
1995 |
Miller, P.E. :
Glaucoma W.B. Saunders Co., Philadelphia J.D. Bonagura and R.W. Kirk (eds.). Kirk's Current Veterinary Therapy XII Small Animal Practice, p. 1265-1272 |
1995 |
Kural,E.,Lindley,D.,Krohne,S.: :
Canine glaucoma .1 Compendium on Continuing Education for the Practicing Veterinarian 17:1017 ff., 1995. |
1995 |
Kural,E.,Lindley,D.,Krohne,S.: :
Canine glaucoma .2 Compendium on Continuing Education for the Practicing Veterinarian 17:1253 ff., 1995. |
1995 |
Brooks,D.E.,Strubbe,D.T.,Kubilis,P.S.,Mackay,E.O.,Samuelson,D.A.,Gelatt,K.N.: :
Histomorphometry of the optic nerves of normal dogs and dogs with hereditary glaucoma Experimental Eye Research 60:71-89, 1995. Pubmed reference: 7720807 . |
1994 |
Spiess,B.M.: :
[Inherited Ocular Diseases in the Entlebucher Mountain Dog] Schweizer Archiv Fur Tierheilkunde 136:105-110, 1994. Pubmed reference: 8171308 . |
1990 |
Slatter, D :
Fundamentals of Veterinary Ophthalmology W. B. Saunders Co., Philadelphia |
1990 |
Brooks,D.E.: :
Glaucoma in the Dog and Cat Veterinary Clinics of North America-Small Animal Practice 20:775-797, 1990. Pubmed reference: 2194358 . |
1987 |
vanderLinde-Sipman,J.S.: :
Dysplasia of the pectinate ligament and primary glaucoma in the Bouvier des Flandres dog. Vet Pathol 24:201-6, 1987. Pubmed reference: 3603960 . |
1986 |
Hedhammar,A.: :
[Current situation regarding the eradication of genetically conditioned eye disorders in Sweden] Svensk Veterinartidning 38:152-160, 1986. |
1981 |
Gelatt,K.N.,Gum,G.G.: :
Inheritance of primary glaucoma in the Beagle. Am J Vet Res 42:1691-3, 1981. Pubmed reference: 7325430 . |
1980 |
Peiffer,R.L.,Gum,G.G.,Grimson,R.C.,Gelatt,K.N.: :
Aqueous humor outflow in Beagles with inherited glaucoma: constant pressure perfusion. Am J Vet Res 41:1808-13, 1980. Pubmed reference: 7212410 . |
1977 |
Gelatt,K.N.,Peiffer,R.L.,Gwin,R.M.,Gum,G.G.,Williams,L.W.: :
Clinical manifestations of inherited glaucoma in the beagle. Invest Ophthalmol Vis Sci 16:1135-42, 1977. Pubmed reference: 924743 . |
1972 |
Gelatt,K.N.: :
Familial glaucoma in the Beagle dog Journal of the American Animal Hospital Association 8:23-28, 1972. |
1968 |
Lovekin,L.G.,Bellhorn,R.W.: :
Clinicopathologic changes in primary glaucoma in the Cocker Spaniel American Journal of Veterinary Research 29:379-385, 1968. |
1968 |
Martin,C.L.,Wyman,M.: :
Glaucoma in the Basset Hound Journal of the American Veterinary Medical Association 153:1320-1327, 1968. Pubmed reference: 5748475 . |
1967 |
Roberts,S.R.: :
Recognizing glaucoma: the appearance, course, and effects of the disease in clinical veterinary medicine Proceedings of the American Society of Veterinary Ophthalmology, Dallas :8-12, 1967. |
1964 |
Lovekin,L.G.: :
Primary glaucoma in dogs. J Am Vet Med Assoc 145:1081-91, 1964. Pubmed reference: 14235477 . |
1957 |
Magrane,W.G.: :
Canine glaucoma. II. Primary classification. J Am Vet Med Assoc 131:372-4, 1957. Pubmed reference: 13475121 . |
1957 |
Magrane,W.G.: :
Canine glaucoma. IV. Medical and surgical treatment Journal of the American Veterinary Medical Association 131:456-464, 1957. Pubmed reference: 13475134 . |
1957 |
Magrane,W.G.: :
Canine glaucoma. III. Secondary classification. J Am Vet Med Assoc 131:374-8, 1957. Pubmed reference: 13475122 . |
1957 |
Magrane,W.G.: :
Canine glaucoma. I. Methods of diagnosis. J Am Vet Med Assoc 131:311-4, 1957. Pubmed reference: 13475109 . |
1950 |
Jourdan,R.H.: :
Pathogenesis of canine glaucoma. J Am Vet Med Assoc 117:419-22, 1950. Pubmed reference: 14784441 . |