A plasma metabolite-based test to detect minimal residual disease in post-surgery colorectal cancer patients
| Title | A plasma metabolite-based test to detect minimal residual disease in post-surgery colorectal cancer patients |
|---|---|
| Description | Background: Colorectal cancer is among the leading causes of cancer-related deaths worldwide, predominantly caused by recurrence after treatment, underscoring the need for novel diagnostic biomarkers for early detection of relapse. We hypothesize that patient response to cancer is linked closely to metabolic changes and can be detected in the blood as an indicator for recurrence. Methods: Full metabolomics analysis was performed on the longitudinal samples of 160 patients with 30 relapse cases, totaling 546 serological samples. Key biomarkers that distinguish relapse and non-relapse patients were identified, and an MRD detection algorithm was constructed based on the discovered metabolic biomarkers. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA032102 |
| Release Date | 2024-11-13 |
| Submitter | Xiaojian Wu (wuxjian@mail.sysu.edu.cn) |
| Organization | The Sixth Affiliated Hospital, Sun Yat-sen University |
| Submission Date | 2024-11-11 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007853-01 | Injection_order | 1 | Metabolome Data by Mass Spectrometry (MS) | 156.5 KB | csv | 0 | |
| OMIX007853-02 | Metabolite_raw_data | 1 | Metabolome Data by Mass Spectrometry (MS) | 13.4 MB | csv | 0 |