1. Yearling coho salmon were fed diets containing the flesh of sexually mature adult coho salmon from Lakes Ontario, Erie and Michigan; Pacific Ocean coho salmon and a commercial trout chow were used to prepare control diets. The fish were fed the experimental diets for 27 weeks. Samples were taken of fed fish and fish fed for 27 weeks and then food deprived for 4 weeks. 2. Total accumulated organochlorine in the recipient was directly proportional to dietary total organochlorine levels, although there were considerable interlake differences in the degree of clearance of specific organochlorine compounds. 3. There was evidence of changes in thyroid physiology, hematocrit, liver structure and inter-renal gland activity in recipients fed the Great Lakes' coho salmon, apparently correlated with organochlorine bioaccumulation.
