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Current radiology reports
Jun 01, 2013;1 (2): 102-114.

Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications.

Feliks Kogan, Hari Hariharan, Ravinder Reddy
Author Information
  1. Feliks Kogan: Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, B1 Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA 19104.
PMID: 23730540 DOI: 10.1007/s40134-013-0010-3

Abstract

Chemical exchange saturation transfer (CEST) is a magnetic resonance imaging (MRI) contrast enhancement technique that enables indirect detection of metabolites with exchangeable protons. Endogenous metabolites with exchangeable protons including many endogenous proteins with amide protons, glycosaminoglycans (GAG), glycogen, myo-inositol (MI), glutamate (Glu), creatine (Cr) and several others have been identified as potential endogenous CEST agents. These endogenous CEST agents can be exploited as non-invasive and non-ionizing biomarkers of disease diagnosis and treatment monitoring. This review focuses on the recent technical developments in endogenous CEST MRI from various metabolites as well as their potential clinical applications. The basic underlying principles of CEST, its potential limitations and new techniques to mitigate them are discussed.

Keywords

APT CEST Chemical Exchange GluCEST MRI Molecular Imaging

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Grants

  1. P41 EB015893/NIBIB NIH HHS
  2. R21 DA032256/NIDA NIH HHS
  3. T32 EB009384/NIBIB NIH HHS
Journal Article

Word Cloud

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