Antimicrobial Stewardship and Antimicrobial Resistance.

Louis B Rice
Author Information
  1. Louis B Rice: Department of Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA. Electronic address: lrice@lifespan.org.

Abstract

Antimicrobial stewardship programs aim to reduce costs, optimize therapeutic outcomes, and reduce antimicrobial resistance. Reductions of antimicrobial resistance are the most elusive because emergence and spread of resistant bacteria involves antimicrobial selective pressure and lapses in infection control techniques. The relationship between antimicrobial usage and resistance is not always direct. The understanding of which techniques are most effective is limited because many studies are descriptive or quasiexperimental. Recent meta-analyses or systematic reviews of stewardship programs offer encouragement that some interventions reduce overall antimicrobial selective pressure and, where associated with infection control interventions, impact resistance rates in individual institutions.

Keywords

MeSH Term

Anti-Bacterial Agents
Antimicrobial Stewardship
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Drug Therapy, Combination
Humans
Infection Control
Inservice Training
Leadership
Medical Staff, Hospital

Chemicals

Anti-Bacterial Agents

Word Cloud

Created with Highcharts 10.0.0AntimicrobialantimicrobialresistancestewardshipreduceprogramsselectivepressureinfectioncontroltechniquesinterventionsaimcostsoptimizetherapeuticoutcomesReductionselusiveemergencespreadresistantbacteriainvolveslapsesrelationshipusagealwaysdirectunderstandingeffectivelimitedmanystudiesdescriptivequasiexperimentalRecentmeta-analysessystematicreviewsofferencouragementoverallassociatedimpactratesindividualinstitutionsStewardshipResistancecyclingrestrictionDecisionsupportInterventions

Similar Articles

Cited By