Rujiao Li

Senior Engineer

Team Leader, Methylation Bank

Email: lirj (AT)

Tel: +86 (10) 8409-7638


  • Senior Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences (CAS), China, 2009−Present

  • Engineer, Beijing Institute of Genomics, Chinese Academy of Sciences (CAS), China, 2008−2009

  • Senior Engineer, Beijing Hongcam Software Technologies Co.,Ltd., China, 2005−2007


  • PhD in Physical Chemistry, Jilin University, China, 2005

  • BS in Chemistry, Jilin University, China, 2000


  • Bioinformatics & Epigenetics

  • Big Data Integration and Analytics



  1. Zong W#, Kang H#, Xiong Z, Ma Y, Jin T, Gong Z, Yi L, Zhang M, Wu S, Wang G, Bao Y*Li R*scMethBank: a database for single-cell whole genome DNA methylation mapsNucleic Acids Res, 2021, doi: 10.1093/nar/gkab833.

  2. Xiong Z#, Yang F#, Li M#, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R*, Zhang Z*, Bao Y*, EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association studyNucleic Acids Res, 2021, doi: 10.1093/nar/gkab972.

  3. Li Ras co-first author in CNCB-NGDC and Partners (2022), Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022Nucleic Acids Res, 2021, doi: 10.1093/nar/gkab951.

  4. Li Ras co-first author in CNCB-NGDC and Partners (2021), Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021, Nucleic Acids Res, 2021, 49(D1):D18-D28.

  5. Song S#, Ma L#, Zou D#, Tian D#, Li C#, Zhu J, # …, Li R, …, Zhang Z*, Zhao W*, Xue Y*, BaoY*The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVRGenomics Proteomics Bioinformatics, 2020, 18, 749–759. 

  6.  Chen M#, Ma Y#Li R*, Bao Y*Current status and prospects of genomics data analysis methods. Front Data Comput. 2020, 2, 1-19.

  7. Li Ras co-first author in National Genomics Data Center Members and Partners (2020), Database Resources of the National Genomics Data Center in 2020, Nucleic Acids Res2020, 48(D1):D24-D33.[PMID: 31702008]

  8.  Xiong Z, Li M, Yang F, Ma Y, Sang J, Li R, ... & Bao, Y., EWAS Data Hub: a resource of DNA methylation array data and metadataNucleic Acids Res2020, 48(D1):D890-D895. [PMID: 31584095]

  9. Zhao W*, Song S*, Chen M*, Zou D*, Ma L*, Ma Y, Li R, Hao LL, Li C, Tian D et alThe 2019 novel coronavirus resourceYi Chuan, 2020, 42(2):212-221. [PMID: 32102777]

  10. Zhao Y#, Wang J#, Liang F, Liu Y, Wang Q, Zhang H, Jiang M, Zhang Z, Zhao W, Bao Y, Zhang Z, Wu J, Asmann Y*, Li R*, Xiao J*, NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Res2019, 47(D1):D163-D169. [PMID=30335176]

  11. Li M, Zou D, Li Z, Gao R, Sang J, Zhang Y, Li R, Xia L, Zhang T, Niu G, Bao Y, Zhang Z, EWAS Atlas: a curated knowledgebase of epigenome-wide association studies. Nucleic Acids Res. 2019, 47(D1):D983-D988. [PMID=30364969]

  12. Li R#*, Liang F#Li M#, Zou D#, Sun S, Zhao Y, Zhao W, Bao Y, Xiao J, Zhang Z*, MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res2018, 46(D1):D288-D295. [PMID=29161430]

  13. Li Ras co-first author in BIG Data Center Members, Database Resources of the BIG Data Center in 2018Nucleic Acids Res, 2018, 46(D1): D14-D20. [PMID=29036542]

  14. Li Ras co-first author in BIG Data Center Members, The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res, 2017, 45(D1), D18-24.

  15. Jin J, Li R#, Jiang C, Zhang R, Ge X, Liang F, Sheng X, Dai W, Chen M, Wu J, Xiao J*, Su W*Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cellsBMC genomics, 2017,18(Suppl 1):933. [PMID=28198671]

  16. Pan Y, Liang F, Li R, Qian W*MarR-Family Transcription Factor HpaR Controls Expression of the vgrR-vgrS Operon of Xanthomonas campestris pv. campestrisMolecular plant-microbe interactions: MPMI 2017. [PMID=29077520]

  17. Peng B#, Pan Y#Li R#, Wei J, Liang F, Wang L, Wang F, Qian W*An Essential Regulatory System Originating from Polygenic Transcriptional Rewiring of PhoP-PhoQ of Xanthomonas campestrisGenetics, 2017. [PMID=28550013]

  18. Yuan L, Yu Y, Zhu Y, Li Y, Li C, Li R, Ma Q, Siu GK, Yu J, Jiang T, Xiao J, Kang Y, GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomesBMC genomics, 2017, 18(Suppl 1):952. [PMID=28198678]

  19. Liu Q, Liu G, Wang T, Fu J, Li R, Song L, Wang ZG, Ding B, Chen F, Enhanced Stability of DNA Nanostructures by Incorporation of Unnatural Base PairsChem phys chem: a European journal of chemical physics and physical chemistry, 2017, 18(21):2977-2980. [PMID=28856771]

  20. Liang F, Hao L, Wang J, Shi S, Xiao J*Li R*BS-RNA: An efficient mapping and annotation tool for RNA bisulfite sequencing dataComputational biology and chemistry, 2016, 65:173-177. [PMID=27647160]

  21. Zou D, Sun S, Li R, Liu J, Zhang J, Zhang Z*MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming dataNucleic Acids Res2015, 43(Database issue):D54-58. [PMID=25294826]

  22. Li J#Li R#, Wang Y, Hu X, Zhao Y, Li L, Feng C, Gu X, Liang F, Lamont SJ, Hu S, Zhou H, Li N, Genome-wide DNA methylome variation in two genetically distinct chicken lines using MethylC-seqBMC genomics, 2015, 16(1):851.[PMID=26497311]

  23. Zhang Z, Jin Z, Zhao Y, Zhang Z, Li R, Xiao J, Wu J, Systematic study on G-protein couple receptor prototypes: did they really evolve from prokaryotic genes? IET systems biology 2014, 8(4):154-161. [PMID=25075528]

  24. Liang F#, Tang B#, Wang Y, Wang J, Yu C, Chen X, Zhu J, Yan J, Zhao W*, Li R*WBSA: web service for bisulfite sequencing data analysisPloS one, 2014, 9(1), e86707.[PMID=24497972]

  25. Zhang R, Hao L, Wang L, Chen M, Li W, Li R, Yu J, Xiao J, Wu J, Gene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromesBMC genomics, 2013, 14 Suppl 5:S8. [PMID=24564826]

  26. Zhao W, Liu W, Tian D, Tang B, Wang Y, Yu C,Li R, Ling Y, Wu J, Song S, Hu S, wapRNA: a web-based application for the processing of RNA sequencesBioinformatics, 2011,27(21):3076-3077. [PMID=21896507]

  27. Zhang M, Li R, Wu D, Sun XY, Li Z, Sun C, Ab initio Study on the Dipole Moments, Polarizabilities and First Hyperpolarizabilities of Fluor ide-water Clusters F-(H2O) n (n= 1-4)., Chemical Journal of Chinese Universities, 2005, 25:515-517.

  28. Li R, Li Z, Di W, Hao X,Li R, Sun C, Long-range pi-type hydrogen bond in the dimers CH2O-HF, CH2O-H2O, and CH2O-NH3Int J Quantum Chem, 2005, 103(3):299-307. [PMID=WOS:000228770900007]

  29. Li R#, Li Z, Wu D, Chen W, Li Y, Wang B, Sun C, Proton transfer of NH3-HCl catalyzed by only one moleculeJ Phys Chem A, 2005, 109(4):629-634. [PMID=WOS:000226626300013]

  30. Wang B, Li Z, Wu D, Hao X, Li R, Sun C, Ab initio study of the interaction hyperpolarizabilities of H-bond dimers between two pi-systemsJ Phys Chem A, 2004,108(13):2464-2468. [PMID=WOS:000220524300016]

  31. Li R#, Li Z, Wu D, Hao X, Wang B, Sun C, Ab initio study of the interaction hyperpolarizabilities of HCN-HF and HNC-HF complexesJ Phys Chem A, 2003, 107(32):6306-6310. [PMID=WOS:000184664700025]

  32. Li R#, Li Z, Wu D, Hao X, Li Y, Wang B, Tao F, Sun C, Density functional study of structures and interaction hyperpolarizabilities of NH3-HCl-(H2O)n (n=0-4) clustersChemical Physics Letters, 2003, 372(5-6):893-898. [PMID=WOS:000182795100047]