| URL: | https://ngdc.cncb.ac.cn/hervd |
| Full name: | Human endogenous retroviruses and diseases Atlas |
| Description: | HervD Atlas aggregates tens of thousands of high-quality data regarding the HERV-disease associations gathered from extensive publications for the first time. By incorporating findings from studies worldwide, HervD Atlas will serve as a valuable resource, enhancing the accessibility and usability of HERV-disease association discoveries. HervD will provide comprehensive and up-to-date knowledge, accelerate paradigm changes in disease research, and facilitate the exploration of HERVs as novel diagnostic and therapeutic strategies. |
| Year founded: | 2023 |
| Last update: | |
| Version: | v1.0 |
| Accessibility: |
Accessible
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| Country/Region: | China |
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| University/Institution: | Beijing Institute of Genomics, Chinese Academy of Sciences |
| Address: | National Genomics Data Center Beijing Institute of Genomics (China National Center for Bioinformation), Chinese Academy of Sciences No. 104 building, No.1 Beichen West Road, Chaoyang District Beijing 100101, China Tel: +86 (10) 8409-7443 Fax: +86 (10) 8409-7443 |
| City: | Beijing |
| Province/State: | |
| Country/Region: | China |
| Contact name (PI/Team): | HervD Atlas |
| Contact email (PI/Helpdesk): | hervd@big.ac.cn |
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HervD Atlas: a curated knowledgebase of associations between human endogenous retroviruses and diseases. [PMID: 37870452]
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been conducted to uncover their specific roles. Despite these efforts, a comprehensive source of HERV-disease association still needs to be added. To address this gap, we introduce the HervD Atlas (https://ngdc.cncb.ac.cn/hervd/), an integrated knowledgebase of HERV-disease associations manually curated from all related published literature. In the current version, HervD Atlas collects 60 726 HERV-disease associations from 254 publications (out of 4692 screened literature), covering 21 790 HERVs (21 049 HERV-Terms and 741 HERV-Elements) belonging to six types, 149 diseases and 610 related/affected genes. Notably, an interactive knowledge graph that systematically integrates all the HERV-disease associations and corresponding affected genes into a comprehensive network provides a powerful tool to uncover and deduce the complex interplay between HERVs and diseases. The HervD Atlas also features a user-friendly web interface that allows efficient browsing, searching, and downloading of all association information, research metadata, and annotation information. Overall, the HervD Atlas is an essential resource for comprehensive, up-to-date knowledge on HERV-disease research, potentially facilitating the development of novel HERV-associated diagnostic and therapeutic strategies. |