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The abnormal RNA editing genes are significantly enriched in three networks based on Ingenuity Pathway Analysis (IPA).

Top Diseases and Functions: Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Cardiovascular Disease.

Ingenuity Canonical Pathways
Ingenuity Canonical Pathways Ratio Molecules
Glutamate Receptor Signaling 0.0938
Amyotrophic Lateral Sclerosis Signaling 0.05
Gap Junction Signaling 0.028
CREB Signaling in Neurons 0.0221
Calcium Signaling 0.0187
Neuropathic Pain Signaling In Dorsal Horn Neurons 0.0252
Synaptic Long Term Potentiation 0.0224
Synaptic Long Term Depression 0.0159
Serotonin Receptor Signaling 0.0377
Molecular Mechanisms of Cancer 0.00746
Protein Kinase A Signaling 0.00726
dTMP De Novo Biosynthesis 0.0714
Glioblastoma Multiforme Signaling 0.0116
Serotonin and Melatonin Biosynthesis 0.0588
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 0.01
Role of JAK1, JAK2 and TYK2 in Interferon Signaling 0.0417
Sonic Hedgehog Signaling 0.0323
Role of JAK2 in Hormone-like Cytokine Signaling 0.0294
autophagy 0.0152
Basal Cell Carcinoma Signaling 0.0137
Ephrin B Signaling 0.0133
VDR/RXR Activation 0.0127
Antiproliferative Role of Somatostatin Receptor 2 0.0118
IL-3 Signaling 0.0112
Growth Hormone Signaling 0.0112
JAK/Stat Signaling 0.0112
Erythropoietin Signaling 0.0111
FGF Signaling 0.0105
IL-4 Signaling 0.0103
CTLA4 Signaling in Cytotoxic T Lymphocytes 0.0101
STAT3 Pathway 0.00962
TR/RXR Activation 0.00952
Melanocyte Development and Pigmentation Signaling 0.00943
p53 Signaling 0.00901
SAPK/JNK Signaling 0.00901
IGF-1 Signaling 0.00877
VEGF Signaling 0.0087
LXR/RXR Activation 0.00781
Natural Killer Cell Signaling 0.00752
CD28 Signaling in T Helper Cells 0.0073
Renin-Angiotensin Signaling 0.0073
Aryl Hydrocarbon Receptor Signaling 0.0068
Corticotropin Releasing Hormone Signaling 0.00671
D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis 0.00667
D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis 0.00667
Phagosome Maturation 0.00645
3-phosphoinositide Degradation 0.00606
D-myo-inositol-5-phosphate Metabolism 0.00592
Acute Phase Response Signaling 0.00562
Mitochondrial Dysfunction 0.00532
Agranulocyte Adhesion and Diapedesis 0.00515
B Cell Receptor Signaling 0.00503
Clathrin-mediated Endocytosis Signaling 0.00476
3-phosphoinositide Biosynthesis 0.00467
Osteoarthritis Pathway 0.00457
Systemic Lupus Erythematosus Signaling 0.00422
Superpathway of Inositol Phosphate Compounds 0.00386
G-Protein Coupled Receptor Signaling 0.00345
Neuroinflammation Signaling Pathway 0.00307
Axonal Guidance Signaling 0.00216
Ingenuity Canonical Biological Processes
Category Disease, Function Annotation p-Value Molecules
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation of brain cells 1.28E-10
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation of brain 1.93E-9
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation of hippocampal cells 3.24E-9
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation 9.34E-9
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation of CA1 neuron 1.04E-8
  • Cardiovascular Disease
 Aneurysm 3.34E-7
  • Cellular Assembly and Organization
  • Cellular Function and Maintenance
 Depolarization of cellular membrane 3.56E-7
  • Neurological Disease
 Movement Disorders 4.01E-7
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Synaptic transmission 7.2E-7
  • Developmental Disorder
  • Skeletal and Muscular Disorders
 Hypoplasia of muscle 7.88E-7
  • Psychological Disorders
 Major affective disorder 8.84E-7
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation of hippocampal CA1 region 1.06E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Excitatory postsynaptic potential 1.14E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long-term potentiation of hippocampus 1.33E-6
  • Cell Morphology
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Plasticity of synapse 1.51E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Excitatory postsynaptic potential of neurons 2.46E-6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Neurotransmission 2.97E-6
  • Behavior
 Behavior 4.25E-6
  • Cellular Assembly and Organization
  • Cellular Function and Maintenance
 Depolarization of plasma membrane 4.33E-6
  • Cardiovascular System Development and Function
 Preservation of elastic lamina 4.53E-6
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Arterial aneurysm 5.24E-6
  • Nervous System Development and Function
 Dedepression of CA1 neuron 5.77E-6
  • Nervous System Development and Function
 Depotentiation of CA1 neuron 5.77E-6
  • Neurological Disease
 Progressive neurological disorder 6.48E-6
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Dementia 6.85E-6
  • Nervous System Development and Function
  • Neurological Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Abnormal morphology of brain 8.22E-6
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Behavioral variant frontotemporal dementia 1.04E-5
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Development of vascular lesion 1.07E-5
  • Nervous System Development and Function
  • Neurological Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Abnormal morphology of cerebral cortex 1.08E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Seizure disorder 1.09E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Early-onset encephalopathy 1.32E-5
  • Neurological Disease
  • Psychological Disorders
 Major depression 2.31E-5
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
 Psoriasis 2.35E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Inhibitory postsynaptic potential 2.43E-5
  • Neurological Disease
  • Psychological Disorders
 Bipolar disorder 2.45E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Synaptic transmission of nervous tissue 2.82E-5
  • Organismal Development
 Morphology of head 3.28E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Action potential of neurons 3.77E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Seizures 4.27E-5
  • Nervous System Development and Function
 Electrophysiology of nervous system 4.6E-5
  • Cellular Movement
 Migration of cells 4.72E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long term depression of neurons 5.16E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long term depression 5.68E-5
  • Nervous System Development and Function
  • Neurological Disease
 Abnormal morphology of nervous system 6.01E-5
  • Cell Morphology
 Morphology of fibrosarcoma cell lines 6.42E-5
  • Amino Acid Metabolism
  • Small Molecule Biochemistry
 Removal of L-glutamic acid 6.42E-5
  • Organismal Development
 Development of endocrine gland 6.81E-5
  • Cell Morphology
  • Nervous System Development and Function
  • Tissue Morphology
 Morphology of neurons 7.07E-5
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Abnormality of cerebral cortex 7.31E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Synaptic transmission of cells 8.08E-5
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 AMPA mediated synaptic current 8.8E-5
  • Dermatological Diseases and Conditions
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Hyperesthesia 9.56E-5
  • Organismal Development
  • Organismal Injury and Abnormalities
 Abnormal morphology of head 1.07E-4
  • Neurological Disease
 Cognitive impairment 1.14E-4
  • Skeletal and Muscular System Development and Function
 Grip strength 1.33E-4
  • Developmental Disorder
  • Skeletal and Muscular Disorders
 Hypoplasia of vascular smooth muscle cells 1.37E-4
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Synaptic transmission of cerebral cortex cells 1.43E-4
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Skeletal and Muscular Disorders
 Autosomal recessive early-onset Parkinson disease 1.43E-4
  • Cellular Movement
 Cell movement 1.44E-4
  • Cancer
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Neurofibromatosis 1.46E-4
  • Cell Morphology
  • Cellular Function and Maintenance
 Transmembrane potential 1.49E-4
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long term depression of synapse 1.55E-4
  • Cell Death and Survival
 Apoptosis 1.57E-4
  • Cell Death and Survival
 Apoptosis of neurons 1.57E-4
  • Cell Death and Survival
  • Cellular Compromise
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Neurodegeneration of pyramidal neurons 1.67E-4
  • Cancer
  • Organismal Injury and Abnormalities
 Head and neck tumor 1.71E-4
  • Cell Morphology
  • Nervous System Development and Function
  • Neurological Disease
  • Tissue Morphology
 Abnormal morphology of neurons 1.73E-4
  • Cell Death and Survival
 Necrosis 1.84E-4
  • Metabolic Disease
 Glucose metabolism disorder 1.89E-4
  • Developmental Disorder
  • Neurological Disease
 Mental retardation 1.99E-4
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Aortic aneurysm 2.06E-4
  • Tissue Morphology
 Quantity of lymphoma cell lines 2.12E-4
  • Nervous System Development and Function
 Morphology of nervous system 2.33E-4
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Diabetes mellitus 2.5E-4
  • Developmental Disorder
 Overgrowth syndrome 2.69E-4
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Long term depression of CA1 neuron 2.71E-4
  • Cellular Development
  • Cellular Growth and Proliferation
 Cell proliferation of lymphoma cell lines 2.83E-4
  • Neurological Disease
 Progressive motor neuropathy 2.84E-4
  • Cell Death and Survival
 Neuronal cell death 2.97E-4
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Progressive encephalopathy 3.02E-4
  • Cellular Movement
 Cell movement of tumor cell lines 3.04E-4
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Skeletal and Muscular Disorders
 Late-onset Parkinson disease 3.22E-4
  • Tissue Morphology
 Quantity of tumor cell lines 3.29E-4
  • Cell Death and Survival
 Cell death 3.36E-4
  • Cardiovascular Disease
  • Metabolic Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Cerebral amyloid angiopathy 3.41E-4
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Familial motor neuron disease 3.52E-4
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
 Transmigration of phagocytes 4.07E-4
  • Metabolic Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Alzheimer disease 4.45E-4
  • Cell Death and Survival
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Cell death of pyramidal neurons 4.49E-4
  • Cellular Growth and Proliferation
 Colony formation of cells 4.57E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Desmoplastic medulloblastoma 4.6E-4
  • Behavior
 Abnormal emotional behavior 5.2E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Large cell or anaplastic medulloblastoma 5.26E-4
  • Organismal Injury and Abnormalities
 Edema 5.5E-4
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Development of atherosclerotic lesion 5.57E-4
  • Nervous System Development and Function
  • Neurological Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Abnormal morphology of hippocampus 5.57E-4
  • Organismal Development
 Size of body 5.72E-4
  • Cellular Movement
 Migration of tumor cell lines 5.83E-4
  • Neurological Disease
  • Skeletal and Muscular Disorders
 Neuromuscular disease 6.04E-4
  • Cancer
  • Organismal Injury and Abnormalities
 Angiogenesis of malignant tumor 6.16E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Central nervous system cancer 6.42E-4
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Frontotemporal lobar degeneration or amyotrophic lateral sclerosis 6.46E-4
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Myelomonocytic leukemia 6.64E-4
  • Cell Death and Survival
 Killing of cells 7.79E-4
  • Cellular Development
  • Cellular Growth and Proliferation
 Proliferation of leukemia cell lines 8.02E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Glioma 8.3E-4
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Glioma cancer 8.45E-4
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Lip cancer 8.63E-4
  • Behavior
  • Nervous System Development and Function
 Spatial memory 8.79E-4
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Formation of vascular lesion 9.14E-4
  • Dermatological Diseases and Conditions
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Hyperalgesia 9.44E-4
  • Psychological Disorders
 Anxiety Disorders 9.52E-4
  • Cell Death and Survival
  • Nervous System Development and Function
 Cell viability of neurons 9.71E-4
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Early infantile epileptic encephalopathy type 41 0.001
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Peripheral vascular disease 0.00101
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Malignant epithelial ovarian tumor 0.00103
  • Behavior
 Learning 0.00104
  • Tissue Development
 Formation of gland 0.00107
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Oral tumor 0.00107
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Choroid plexus tumor 0.00111
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Synaptic transmission of pyramidal neurons 0.00112
  • Behavior
 Emotional behavior 0.00117
  • Cell Death and Survival
  • Cell Morphology
  • Nervous System Development and Function
  • Organ Morphology
  • Organismal Development
 Loss of cerebral cortex cells 0.00119
  • Cell-To-Cell Signaling and Interaction
 Aggregation of cervical cancer cell lines 0.0012
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Anaplastic medulloblastoma 0.0012
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of Burkitt lymphoma cells 0.0012
  • Cancer
  • Connective Tissue Disorders
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Autosomal dominant Neurofibromatosis-Noonan syndrome 0.0012
  • Cancer
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Autosomal dominant familial spinal neurofibromatosis 0.0012
  • Cancer
  • Dermatological Diseases and Conditions
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Cafe-au-lait macules with pulmonary stenosis 0.0012
  • Cell-To-Cell Signaling and Interaction
  • Cellular Assembly and Organization
  • Nervous System Development and Function
 Cell-cell contact of axons 0.0012
  • Cellular Growth and Proliferation
  • Nervous System Development and Function
 Colony formation of Schwann cells 0.0012
  • Metabolic Disease
 Deficiency of tryptophan 5-monooxygenase 0.0012
  • Embryonic Development
  • Tissue Morphology
 Deformation of floor plate 0.0012
  • Nervous System Development and Function
  • Tissue Morphology
 Density of GABAergic neurons 0.0012
  • Inflammatory Response
 Fibroinflammatory response 0.0012
  • Nervous System Development and Function
 Growth of nerve trunk 0.0012
  • Cellular Movement
 Invasion of Schwann cells 0.0012
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Major affective disorder type 1 0.0012
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
 Multiple cafe-au-lait spots 0.0012
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Tissue Morphology
 Pseudarthrosis 0.0012
  • Nervous System Development and Function
  • Tissue Morphology
 Quantity of type-2 astrocytes 0.0012
  • Cellular Movement
 Segregation of thalamic cells 0.0012
  • Cellular Assembly and Organization
 Stabilization of sarcolemma 0.0012
  • Neurological Disease
  • Psychological Disorders
 Susceptibility to attention deficit-hyperactivity disorder type 7 0.0012
  • Cancer
 Transformation of pancreatic cancer cell lines 0.0012
  • Cellular Function and Maintenance
 Turnover of myofiber 0.0012
  • Cell Morphology
 Morphology of sarcoma cell lines 0.00122
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Familial mental retardation 0.00123
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 T acute lymphoblastic leukemia 0.00132
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hypersensitivity Response
  • Inflammatory Response
  • Lymphoid Tissue Structure and Development
 Proliferation of mast cells 0.00132
  • Cell Cycle
 Interphase of lymphoma cell lines 0.00137
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
 Advanced stage psoriasis 0.0014
  • Cell Cycle
 Arrest in G1 phase of endometrial stromal cells 0.0014
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Autosomal recessive mental retardation type 6 0.0014
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Degeneration of nigrostriatum 0.0014
  • Cell Death and Survival
  • Cell Morphology
  • Nervous System Development and Function
  • Neurological Disease
  • Tissue Morphology
 Loss of hilar interneurons 0.0014
  • Cell-To-Cell Signaling and Interaction
  • Cellular Function and Maintenance
  • Nervous System Development and Function
 Paired-pulse facilitation of mossy fiber cells 0.0014
  • Cardiac Stenosis
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Retinal arterial macroaneurysm with supravalvular pulmonic stenosis 0.0014
  • Nervous System Development and Function
 Sensation 0.0014
  • Embryonic Development
  • Organismal Development
 Development of head 0.00141
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Degeneration of brain 0.00141
  • Cell Death and Survival
 Cell viability of central nervous system cells 0.00143
  • Neurological Disease
 Tremor 0.00145
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Cell viability of leukemia cells 0.00147
  • Cancer
  • Organismal Injury and Abnormalities
 Angiogenesis of tumor 0.00147
  • Nervous System Development and Function
  • Tissue Morphology
 Quantity of astrocytes 0.00149
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Volume of lesion 0.00151
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Formation of aneurysm 0.00153
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
 Proliferation of hematopoietic progenitor cells 0.00155
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Acute monocytic leukemia (M5) 0.00157
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Development of primitive neuroectodermal tumor 0.00158
  • Behavior
  • Nervous System Development and Function
 Memory 0.00158
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
 AIDS-related primary CNS lymphoma 0.0016
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Acute eosinophilic leukemia 0.0016
  • Cell Death and Survival
 Anoikis of hepatoma cell lines 0.0016
  • Cell Death and Survival
  • Embryonic Development
 Apoptosis of metanephric blastema 0.0016
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Autosomal dominant chronic kidney disease 0.0016
  • Nucleic Acid Metabolism
  • Small Molecule Biochemistry
 Biosynthesis of thymidine 0.0016
  • Infectious Diseases
 Chancroid 0.0016
  • Cell Death and Survival
  • Small Molecule Biochemistry
 Cytotoxicity of methotrexate 0.0016
  • Cellular Development
  • Embryonic Development
  • Organismal Development
  • Tissue Development
 Differentiation of gubernaculum 0.0016
  • Hereditary Disorder
  • Kidney Failure
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Frasier syndrome 0.0016
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Glomerulosclerosis of mesangium 0.0016
  • Inflammatory Disease
  • Ophthalmic Disease
  • Organismal Injury and Abnormalities
 Inclusion conjunctivitis 0.0016
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Invasive hydatidiform mole 0.0016
  • Developmental Disorder
 Meacham syndrome 0.0016
  • Cardiovascular Disease
  • Hematological Disease
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Megaloblastic anemia due to dihydrofolate reductase deficiency 0.0016
  • Infectious Diseases
  • Inflammatory Disease
  • Inflammatory Response
  • Neurological Disease
 Meningococcal meningitis 0.0016
  • Hereditary Disorder
  • Nephrosis
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Nephrotic syndrome type 4 0.0016
  • Amino Acid Metabolism
  • Drug Metabolism
  • Small Molecule Biochemistry
  • Vitamin and Mineral Metabolism
 Reduction of folic acid 0.0016
  • Dermatological Diseases and Conditions
  • Organismal Injury and Abnormalities
 Refractory psoriasis 0.0016
  • Connective Tissue Disorders
  • Immunological Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Severe juvenile rheumatoid arthritis 0.0016
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
  • Immune Cell Trafficking
 Tethering of lymphocytes 0.0016
  • Hematological Disease
  • Infectious Diseases
 Vivax malaria 0.0016
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 WT1-related Wilms tumorigenesis 0.0016
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Wilms tumor 1 0.0016
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 X-linked mental retardation type 94 0.0016
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Disorder of basal ganglia 0.00162
  • Embryonic Development
  • Endocrine System Development and Function
  • Organ Development
  • Organismal Development
  • Tissue Development
 Formation of adrenal gland 0.00163
  • Psychological Disorders
 Hyperactive behavior 0.0017
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Epilepsy 0.0017
  • Behavior
 Hyperactivity 0.00175
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Skeletal and Muscular System Development and Function
  • Tissue Development
 Formation of osteoclasts 0.00175
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
 Antagonization of T lymphocytes 0.0018
  • Connective Tissue Disorders
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Au-Kline syndrome 0.0018
  • Cellular Compromise
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Calcification of skeletal muscle cells 0.0018
  • Post-Translational Modification
 Hyperphosphorylation of protein 0.0018
  • Cellular Movement
 Invasion of brain cancer cell lines 0.0018
  • Cellular Growth and Proliferation
 Termination of proliferation of cells 0.0018
  • Cancer
  • Organismal Injury and Abnormalities
 Cancer of secretory structure 0.00182
  • Cell Death and Survival
 Cell death of tumor cell lines 0.00187
  • Organismal Survival
 Organismal death 0.00189
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Abdominal aortic aneurysm 0.00192
  • Behavior
 Ingestion of ethanol 0.00196
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Inhibitory postsynaptic current 0.00197
  • Antimicrobial Response
 Aggregation of rhinovirus 0.002
  • Antigen Presentation
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
  • Humoral Immune Response
  • Inflammatory Response
 Antigen presentation of B lymphocytes 0.002
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Atherosclerosis of abdominal aorta 0.002
  • Nervous System Development and Function
 Calcium permeability of neurons 0.002
  • Carbohydrate Metabolism
  • Drug Metabolism
  • Small Molecule Biochemistry
 Circulation of daunorubicin 0.002
  • Infectious Diseases
 Internalization of Hepatitis C virus 0.002
  • Cellular Assembly and Organization
  • Cellular Compromise
  • Nervous System Development and Function
 Retraction of glial cell projections 0.002
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Tissue Morphology
  • Tumor Morphology
 Size of brain tumor 0.002
  • Endocrine System Disorders
  • Metabolic Disease
 Metabolic syndrome X 0.00202
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Astrocytoma 0.00208
  • Nutritional Disease
 Obesity 0.00209
  • Cell-mediated Immune Response
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
 Transmigration of T lymphocytes 0.00209
  • Cell Death and Survival
 Apoptosis of tumor cell lines 0.00216
  • Organ Morphology
 Abnormal morphology of gland 0.00218
  • Embryonic Development
  • Nervous System Development and Function
  • Organ Development
  • Organ Morphology
  • Organismal Development
  • Tissue Development
  • Visual System Development and Function
 Morphogenesis of camera-type eye 0.00218
  • Organismal Injury and Abnormalities
 Organ Degeneration 0.00219
  • Cancer
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Angiogenesis of pancreatic endocrine tumor 0.0022
  • Cancer
  • Cell Cycle
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Contact growth inhibition of medulloblastoma cells 0.0022
  • Cell Death and Survival
 Killing of Staphylococcus aureus subsp. aureus str. Newman 0.0022
  • Infectious Diseases
  • Neurological Disease
 Rabies 0.0022
  • Cardiovascular Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
 Inflammation of blood vessel 0.0022
  • Embryonic Development
  • Nervous System Development and Function
  • Organ Development
  • Organismal Development
  • Tissue Development
 Development of spinal cord 0.00221
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Synaptic transmission of synapse 0.00224
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
 Transmigration of monocytes 0.00228
  • Embryonic Development
  • Nervous System Development and Function
  • Organ Development
  • Organismal Development
  • Tissue Development
 Development of cerebral cortex 0.00231
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Cervical cancer 0.00233
  • Cellular Movement
 Invasion of tumor cell lines 0.00235
  • Nervous System Development and Function
  • Tissue Morphology
 Density of dopaminergic neurons 0.0024
  • Connective Tissue Development and Function
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Skeletal and Muscular System Development and Function
  • Tissue Development
 Formation of metatarsal bone 0.0024
  • Vitamin and Mineral Metabolism
 Metabolism of dihydrofolate 0.0024
  • Embryonic Development
 Regression of notochord 0.0024
  • Dermatological Diseases and Conditions
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Xanthoma 0.0025
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Ovarian cancer 0.00251
  • Neurological Disease
  • Psychological Disorders
 Obsessive-compulsive disorder 0.00254
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Central nervous system solid tumor 0.00255
  • Behavior
 Social exploration 0.00258
  • Cellular Development
  • Connective Tissue Development and Function
  • Tissue Development
 Differentiation of perichondrial cells 0.0026
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Diabetic nephropathy 0.00261
  • Protein Synthesis
 Quantity of ldl cholesterol in blood 0.00274
  • Cell Death and Survival
  • Nervous System Development and Function
 Cell viability of cortical neurons 0.00278
  • Developmental Disorder
  • Embryonic Development
  • Organismal Development
  • Tissue Morphology
 Abnormal morphology of gonadal ridge 0.0028
  • Cell-To-Cell Signaling and Interaction
 Activation of bone cancer cell lines 0.0028
  • Cell-To-Cell Signaling and Interaction
  • Cellular Assembly and Organization
  • Nervous System Development and Function
 Cell-cell contact of Schwann cells 0.0028
  • Dermatological Diseases and Conditions
  • Infectious Diseases
  • Organismal Injury and Abnormalities
 Complicated skin and skin structure infection 0.0028
  • Cellular Growth and Proliferation
 Cytostasis of endometrial cancer cell lines 0.0028
  • Cell Cycle
 Delay in G1 phase of lymphoma cell lines 0.0028
  • Tissue Development
 Development of mesothelium 0.0028
  • Amino Acid Metabolism
  • Small Molecule Biochemistry
 Inactivation of L-glutamic acid 0.0028
  • Cancer
  • Neurological Disease
  • Ophthalmic Disease
  • Organismal Injury and Abnormalities
 Optic nerve glioma 0.0028
  • Cancer
  • Organismal Injury and Abnormalities
 Extraadrenal retroperitoneal tumor 0.00282
  • Vitamin and Mineral Metabolism
 Quantity of mineral 0.00283
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Type M2 acute myeloid leukemia 0.00288
  • Nervous System Development and Function
 Nociception 0.00289
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Cecum adenocarcinoma 0.00293
  • Cancer
  • Organismal Injury and Abnormalities
 ALK fusion positive solid tumor 0.00295
  • Cellular Assembly and Organization
  • Cellular Function and Maintenance
  • Organ Morphology
  • Skeletal and Muscular System Development and Function
  • Tissue Morphology
 Quantity of smooth muscle cells 0.00295
  • Cancer
  • Organismal Injury and Abnormalities
 Neoplasia of cells 0.00295
  • Cell Death and Survival
 Apoptosis of splenocytes 0.00296
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Tourette syndrome 0.00296
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Chronic myeloid leukemia 0.00299
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Growth of glioma 0.00299
  • Auditory Disease
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Bilateral vestibular schwannoma 0.003
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
 Colony formation of LSK cells 0.003
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Renal and Urological System Development and Function
  • Tissue Development
 Development of renal calyx 0.003
  • Hereditary Disorder
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Familial hemophagocytic lymphohistiocytosis type 2 0.003
  • Cell-mediated Immune Response
  • Lymphoid Tissue Structure and Development
 Frequency of central memory cytotoxic T cells 0.003
  • Cell-mediated Immune Response
  • Lymphoid Tissue Structure and Development
 Frequency of effector memory helper T cells 0.003
  • Amino Acid Metabolism
  • Small Molecule Biochemistry
 Influx of amino acids 0.003
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Lipid core of atherosclerotic plaque 0.003
  • Connective Tissue Development and Function
  • Tissue Morphology
 Quantity of fibrocartilage 0.003
  • Tissue Development
 Remodeling of stroma 0.003
  • Embryonic Development
  • Organ Development
  • Organ Morphology
  • Organismal Development
  • Renal and Urological System Development and Function
  • Tissue Development
 Size of renal medulla 0.003
  • Developmental Disorder
  • Hereditary Disorder
  • Neurological Disease
  • Nutritional Disease
  • Ophthalmic Disease
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 WAGR syndrome with obesity 0.003
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Type M4 acute myeloid leukemia 0.003
  • Cancer
  • Cardiovascular Disease
  • Hematological Disease
  • Organismal Injury and Abnormalities
 Refractory anemia with excess blasts 0.00303
  • Neurological Disease
 Dyskinesia 0.00303
  • Dermatological Diseases and Conditions
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Allodynia 0.00309
  • Behavior
 Spatial learning 0.00313
  • Cancer
  • Organismal Injury and Abnormalities
 ALK mutation positive malignant solid tumor 0.00314
  • Organ Morphology
  • Renal and Urological System Development and Function
 Quantity of nephron 0.00318
  • Cell-To-Cell Signaling and Interaction
 Activation of sarcoma cell lines 0.0032
  • Glomerular Injury
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Diffuse mesangial sclerosis 0.0032
  • Cancer
  • Hematological Disease
  • Hereditary Disorder
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Familial juvenile myelomonocytic leukemia 0.0032
  • Cell Cycle
 Senescence of lymphoma cell lines 0.0032
  • Cell Death and Survival
  • Cell Morphology
  • Nervous System Development and Function
  • Neurological Disease
  • Tissue Morphology
 Loss of neurons 0.00322
  • Cardiac Hemorrhaging
  • Cardiovascular Disease
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
 Bleeding of pericardium 0.00539
  • Cell Death and Survival
  • Renal Necrosis/Cell Death
  • Renal and Urological System Development and Function
 Cell viability of kidney cell lines 0.00787
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Experimental crescentic glomerulonephritis 0.00797
  • Increased Levels of Alkaline Phosphatase
 Increased activation of alkaline phosphatase 0.00819
  • Cell Morphology
  • Glomerular Injury
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Abnormal morphology of mesangial cells 0.00857
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Inflammatory Disease
  • Liver Cirrhosis
  • Organismal Injury and Abnormalities
 Primary biliary cirrhosis 0.0103
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal Transformation
 Transformation of kidney cells 0.0104
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Inflammatory Disease
  • Liver Cirrhosis
  • Organismal Injury and Abnormalities
 Early stage primary biliary cirrhosis 0.0105
  • Cardiac Arteriopathy
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Early-onset premature coronary artery disease 0.0119
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Nephritis 0.0179
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Pyelonephritis 0.0214
  • Cardiac Hypoplasia
  • Cardiovascular Disease
  • Developmental Disorder
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Hypoplasia of myocardium 0.023
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver cancer 0.0246
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver tumor 0.0277
  • Kidney Failure
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Chronic renal failure 0.03
  • Cancer
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal Hyperplasia/Hyperproliferation
  • Renal and Urological Disease
 Hyperplasia of mesangial cells 0.0304
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Focal necrosis of liver 0.0309
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Glomerular Injury
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
  • Tissue Morphology
 Abnormal morphology of glomerular capillary 0.0331
  • Glomerular Injury
  • Organ Development
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Formation of glomerular crescent 0.0339
  • Cancer
  • Gastrointestinal Disease
  • Hematological Disease
  • Hepatic System Disease
  • Immunological Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatosplenic T-cell lymphoma 0.036
  • Glomerular Injury
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Abnormal morphology of mesangial matrix 0.0445
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hemorrhaging
  • Organismal Injury and Abnormalities
 Bleeding of liver 0.0479
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Persistent truncus arteriosus 0.0487
  • Hereditary Disorder
  • Nephrosis
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Familial nephrotic syndrome 0.0511
  • Collagen(s)
  • WT1
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver carcinoma 0.0519
  • Cell Death and Survival
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Apoptosis of podocytes 0.0528
  • Liver Damage
 Hepatotoxicity 0.054
  • Cellular Development
  • Cellular Growth and Proliferation
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Proliferation
  • Organ Development
 Proliferation of liver cells 0.0544
  • Developmental Disorder
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hypoplasia
  • Organismal Injury and Abnormalities
 Hypoplasia of liver 0.0651
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Double outlet right ventricle 0.0659
  • Cardiac Stenosis
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Stenosis of aortic valve 0.067
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Myocardial infarction 0.068
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Glomerulonephritis 0.0688
  • Cardiac Damage
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Cardiotoxicity 0.0704
  • Glomerular Injury
  • Kidney Failure
  • Organismal Injury and Abnormalities
  • Renal Fibrosis
  • Renal and Urological Disease
 Interstitial fibrosis of kidney 0.0787
  • Cardiac Arteriopathy
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Coronary artery disease 0.0804
  • Cardiovascular System Development and Function
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Fibrosis
  • Liver
Proliferation of hepatic stellate cells 0.0867
  • Cardiovascular Disease
  • Heart Failure
  • Organismal Injury and Abnormalities
 Cardiac death 0.09
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Necrosis of liver 0.0931
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal Tubule Injury
  • Renal and Urological Disease
 Proximal tubular toxicity 0.103
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Cell death of kidney cells 0.161
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Development of liver tumor 0.2
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Fibrosis of liver 0.228
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Apoptosis of hepatocytes 0.252
  • ERK1/2
  • Insulin
  • LDLR
  • Mapk
  • Cellular Development
  • Cellular Growth and Proliferation
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Proliferation
  • Organ Development
  • Tissue Development
 Proliferation of hepatocytes 0.264
  • Collagen(s)
  • GLI1
  • Insulin
  • Cardiac Fibrosis
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Fibrosis of heart 0.282
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Hepatic steatosis 0.437
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Cell death of kidney cell lines 0.463
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Inflammation of liver 0.479
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hypertrophy of heart 0.5
  • ERK1/2
  • Insulin
  • NF1
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatocellular carcinoma 1.0
  • Cyclin E
  • GLI1
  • Hsp90

Top Diseases and Functions: Cellular Development, Cellular Growth and Proliferation, Cell Death and Survival.

Ingenuity Canonical Pathways
Ingenuity Canonical Pathways Ratio Molecules
Serotonin Receptor Signaling 0.0377
Caveolar-mediated Endocytosis Signaling 0.0274
Protein Kinase A Signaling 0.00726
Gq Signaling 0.0118
Polyamine Regulation in Colon Cancer 0.0435
Neuroinflammation Signaling Pathway 0.00307
G-Protein Coupled Receptor Signaling 0.00345
Ingenuity Canonical Biological Processes
Category Disease, Function Annotation p-Value Molecules
  • Cell Cycle
  • Embryonic Development
 Entry into senescence of embryonic cell lines 1.34E-7
  • Cell Cycle
  • Cellular Development
  • Connective Tissue Development and Function
 Entry into senescence of fibroblast cell lines 1.34E-7
  • Cellular Growth and Proliferation
 Cytostasis of breast cancer cell lines 1.43E-5
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Compromise
 Breakdown of lysosome 2.64E-5
  • IL6
  • TP53
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
  • Tissue Morphology
 Quantity of Th17 cells 2.95E-5
  • ELAVL1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of lung cancer cells 3.07E-5
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
 Cell cycle progression of breast cancer cell lines 3.25E-5
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Behavior
 Aggressive behavior toward males 3.45E-5
  • ESR1
  • IL6
  • PTEN
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Growth of mammary tumor 3.84E-5
  • ELAVL1
  • ESR1
  • PTEN
  • TP53
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal tumor 4.05E-5
  • AZIN1
  • ESR1
  • IL6
  • PCNA
  • PHTF2
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 Formation of DNA fragment 4.64E-5
  • PCNA
  • TP53
  • Cell Death and Survival
 Recovery of tumor cell lines 4.97E-5
  • IL6
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Large-cell follicular lymphoma 5.66E-5
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Adenoid cystic carcinoma 6.08E-5
  • ESR1
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in G0/G1 phase transition 6.25E-5
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
  • Cellular Development
  • Connective Tissue Development and Function
 Senescence of fibroblast cell lines 6.36E-5
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Testicular teratoma 7.18E-5
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 DNA damage 7.82E-5
  • Organismal Injury and Abnormalities
 Plasmacytosis 8.44E-5
  • ESR1
  • IL6
  • Cell Cycle
 G1/S phase transition of breast cancer cell lines 8.68E-5
  • ELAVL1
  • ESR1
  • TP53
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Reproductive System Development and Function
  • Reproductive System Disease
 Abnormal morphology of uterus 9.61E-5
  • ELAVL1
  • ESR1
  • PTEN
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Tumorigenesis of salivary gland tumor 1.13E-4
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Autosomal dominant breast cancer 1.18E-4
  • ESR1
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 WHO grade IV malignant astrocytoma 1.18E-4
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in cell cycle progression of breast cancer cell lines 1.24E-4
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Familial sarcoma 1.28E-4
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Invasive adenocarcinoma 1.29E-4
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in G1 phase of bladder cancer cell lines 1.34E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Tumorigenesis of prostatic intraepithelial tumor 1.34E-4
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
 Apoptosis of carcinoma 1.45E-4
  • IL6
  • PTEN
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Hereditary tumor 1.46E-4
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TMEM127
  • TP53
  • Cell Cycle
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
 Contact growth inhibition of tumor cell lines 1.48E-4
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
 Transformation of kidney cell lines 1.55E-4
  • ESR1
  • PTEN
  • TP53
  • Connective Tissue Disorders
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Experimentally-induced arthritis of ankle joint 1.57E-4
  • IL6
  • PTEN
  • Cell Cycle
 Delay in cell cycle progression 1.86E-4
  • IL6
  • PCNA
  • PTEN
  • Cell Death and Survival
 Apoptosis of salivary mucous cells 1.94E-4
  • ESR1
  • TP53
  • Cancer
 Transformation of lung cell lines 1.94E-4
  • IL6
  • TP53
  • Lymphoid Tissue Structure and Development
  • Tissue Morphology
 Quantity of bone marrow cells 1.98E-4
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Oropharyngeal tumor 1.98E-4
  • IL6
  • PCNA
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Frontal lobe astrocytoma 2.08E-4
  • PTEN
  • TP53
  • Cell Cycle
  • Embryonic Development
 G1 phase of embryonic stem cells 2.14E-4
  • PTEN
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of large-cell lymphoma 2.21E-4
  • IL6
  • TP53
  • Cell Cycle
 Arrest in G0/G1 phase transition of tumor cell lines 2.28E-4
  • IL6
  • PTEN
  • TP53
  • Biliary Hyperplasia
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Organismal Injury and Abnormalities
 Development of cholangiocarcinoma 2.36E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
  • Tissue Morphology
 Quantity of genital tumor 2.36E-4
  • PTEN
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Glioma susceptibility 2.43E-4
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in growth of melanoma cell lines 2.58E-4
  • IL6
  • TP53
  • Cell Death and Survival
 Apoptosis of lymphoblastoid cell lines 2.58E-4
  • IL6
  • PCNA
  • TP53
  • Cell Cycle
 Interphase of breast cancer cell lines 2.61E-4
  • ELAVL1
  • ESR1
  • IL6
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Parietal lobe astrocytoma 2.66E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Fibroma 2.69E-4
  • ESR1
  • PCNA
  • PTEN
  • TP53
  • Cancer
  • Cell-To-Cell Signaling and Interaction
  • Inflammatory Response
 Cytotoxic reaction of tumor cell lines 2.69E-4
  • IL6
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Tissue Development
  • Tissue Morphology
 Expansion of epithelial stem cells 2.73E-4
  • PTEN
  • TP53
  • Organ Development
 Function of thymus gland 2.73E-4
  • ESR1
  • TP53
  • Cell Cycle
 Cell cycle progression of bone marrow cell lines 2.81E-4
  • ESR1
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Drug Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Concentration of dopamine 2.9E-4
  • DNA Replication
  • Recombination
  • and Repair
 Cleavage of DNA 2.91E-4
  • Cell Morphology
 Morphology of melanoma cell lines 3.14E-4
  • IL6
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of non-Hodgkin lymphoma 3.22E-4
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
  • Gene Expression
 Binding of TATA box 3.22E-4
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Respiratory Disease
  • Tumor Morphology
 Progression of lung tumor 3.22E-4
  • IL6
  • TP53
  • Tissue Development
 Development of organoid 3.31E-4
  • PTEN
  • TP53
  • Cell Cycle
 G1/S phase transition of tumor cell lines 3.36E-4
  • ELAVL1
  • ESR1
  • IL6
  • TP53
  • Cell Cycle
 Aneuploidy of splenocytes 3.39E-4
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal cancer 3.42E-4
  • AZIN1
  • ESR1
  • IL6
  • PHTF2
  • PTEN
  • TP53
  • Organ Development
  • Reproductive System Development and Function
 Ovulation of ovary 3.57E-4
  • ESR1
  • IL6
  • Gene Expression
 Expression of mRNA 3.71E-4
  • CTIF
  • ELAVL1
  • ESR1
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Growth of adenocarcinoma 3.73E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Development of myosarcoma 3.84E-4
  • PTEN
  • TP53
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Damage of brain 3.89E-4
  • ESR1
  • IL6
  • NEIL1
  • PTEN
  • TP53
  • Cancer
  • Cell Cycle
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Senescence of cancer cells 3.93E-4
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Hereditary breast cancer 3.98E-4
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Cell viability of lung cancer cells 4.32E-4
  • PTEN
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Growth of medulloblastoma 4.32E-4
  • PTEN
  • TP53
  • Organismal Injury and Abnormalities
 Premalignant lesion 4.32E-4
  • ESR1
  • PTEN
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Skeletal and Muscular System Development and Function
 Stimulation of smooth muscle cells 4.41E-4
  • IL6
  • PTEN
  • Small Molecule Biochemistry
 Synthesis of nitrite 4.53E-4
  • IL6
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
 Cytostasis of cervical cancer cell lines 4.61E-4
  • IL6
  • TP53
  • Cell Cycle
  • Gene Expression
 Binding of thyroid hormone response element 4.72E-4
  • ESR1
  • TP53
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
 Colony formation of colony-forming units granulocytes 4.72E-4
  • ESR1
  • IL6
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Temporal lobe astrocytoma 4.82E-4
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
 Cytostasis of melanoma cell lines 4.92E-4
  • IL6
  • TP53
  • Cell Cycle
 Arrest in G2 phase of tumor cell lines 5.02E-4
  • ELAVL1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Fibroadenoma 5.03E-4
  • ESR1
  • PTEN
  • Cell Cycle
 Senescence of lymphatic system cells 5.13E-4
  • PTEN
  • TP53
  • Organ Morphology
  • Organismal Development
  • Reproductive System Development and Function
  • Tissue Morphology
 Quantity of sperm 5.3E-4
  • ESR1
  • IL6
  • TP53
  • Cell Cycle
  • Connective Tissue Development and Function
 Arrest in G0/G1 phase transition of fibroblast cell lines 5.35E-4
  • ESR1
  • TP53
  • Organ Development
  • Reproductive System Development and Function
 Growth of genital organ 5.58E-4
  • ESR1
  • PTEN
  • TP53
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal squamous cell carcinoma 5.63E-4
  • Cell Death and Survival
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Apoptosis of neural precursor cells 5.68E-4
  • PTEN
  • TP53
  • Cell Morphology
  • Connective Tissue Development and Function
  • Tissue Morphology
 Area of connective tissue cells 5.68E-4
  • IL6
  • TP53
  • Cancer
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Lymphatic node tumor 5.79E-4
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Development of melanoma 5.81E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Invasive ductal breast carcinoma 5.88E-4
  • ESR1
  • IL6
  • PCNA
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of diffuse lymphoma 6.13E-4
  • IL6
  • TP53
  • Cancer
  • Endocrine System Disorders
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Pheochromocytoma 6.14E-4
  • PTEN
  • TMEM127
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Development of papillary carcinoma 6.49E-4
  • PTEN
  • TP53
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Reproductive System Development and Function
  • Reproductive System Disease
 Abnormal morphology of small uterus 6.61E-4
  • ESR1
  • TRIM25
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in proliferation of tumor cell lines 6.72E-4
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Salivary gland tumor 6.83E-4
  • IL6
  • PTEN
  • TP53
  • Connective Tissue Development and Function
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Skeletal and Muscular System Development and Function
  • Tissue Development
  • Tissue Morphology
 Loss of bone tissue 6.97E-4
  • ESR1
  • IL6
  • Cell Death and Survival
 Cell viability of stem cells 6.99E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of B-cell non-Hodgkin lymphoma 7.22E-4
  • IL6
  • TP53
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Reproductive System Development and Function
  • Tissue Development
 Formation of primordial ovarian follicle 7.22E-4
  • ESR1
  • PCNA
  • Cancer
  • Organismal Injury and Abnormalities
 Growth of squamous-cell carcinoma 7.48E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Infiltrating duct and lobular carcinoma 7.48E-4
  • ESR1
  • TP53
  • Cell Cycle
 G1/S phase transition 7.56E-4
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 Breakage of DNA 7.73E-4
  • PCNA
  • PTEN
  • TP53
  • Cell Cycle
 Cell cycle progression of lymphoblastoid cell lines 7.73E-4
  • IL6
  • PCNA
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Familial lung cancer 7.73E-4
  • PTEN
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Drug Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Abnormal quantity of dopamine 8.26E-4
  • Cancer
  • Organismal Injury and Abnormalities
 Metaplastic carcinoma 8.4E-4
  • PTEN
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Abnormal morphology of liver 8.61E-4
  • ESR1
  • IL6
  • NEIL1
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Embryonic Development
  • Organismal Development
  • Tissue Development
 Proliferation of neural stem cells 8.62E-4
  • IL6
  • PTEN
  • TP53
  • Cell Death and Survival
 Apoptosis of B lymphoblastoid cell lines 8.81E-4
  • IL6
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Cellular Movement
 Recruitment of muscle cells 8.81E-4
  • IL6
  • PTEN
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Tumorigenesis of prostatic carcinoma 8.81E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Invasive breast carcinoma 8.93E-4
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Humoral Immune Response
  • Lymphoid Tissue Structure and Development
  • Tissue Morphology
 Quantity of germinal center 8.94E-4
  • ESR1
  • IL6
  • PTEN
  • Cell Cycle
  • DNA Replication
  • Recombination
  • and Repair
 Homologous recombination of chromosomes 8.95E-4
  • PTEN
  • TP53
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Skeletal and Muscular Disorders
 Parkinson's disease 9.2E-4
  • CTIF
  • HTR2C
  • IL6
  • PCNA
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in proliferation of lung cancer cell lines 9.37E-4
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
 Colony formation of macrophages 9.51E-4
  • ESR1
  • IL6
  • Cancer
  • Organismal Functions
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Inhibition of tumor 9.56E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Metastasis of adenocarcinoma 9.95E-4
  • PTEN
  • TP53
  • Cellular Function and Maintenance
 Cell saturation density 0.00101
  • PTEN
  • TP53
  • Cell Death and Survival
 Cell viability of lymphoblastoid cell lines 0.00107
  • PCNA
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Leiomyosarcoma 0.00108
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Atypical endometrial hyperplasia 0.00108
  • ESR1
  • PTEN
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Large cell neuroendocrine lung carcinoma 0.0011
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in G1 phase of prostate cancer cell lines 0.00115
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Tumorigenesis of intestinal polyp 0.00116
  • PTEN
  • TP53
  • Cell Cycle
 G1 phase of tumor cell lines 0.00116
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Development of mammary tumor 0.00117
  • ESR1
  • PCNA
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Quantity of adenocarcinoma 0.00118
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Papillary renal cell carcinoma type 1 0.00121
  • PTEN
  • TP53
  • Protein Synthesis
 Quantity of cytokine 0.00122
  • Cell Cycle
 Arrest in G1 phase of leukemia cell lines 0.00124
  • IL6
  • TP53
  • Cellular Compromise
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Damage of axons 0.00124
  • IL6
  • PTEN
  • Cellular Compromise
 Stress response of embryonic cell lines 0.00128
  • Cancer
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
  • Tumor Morphology
 Proliferation of mammary tumor cells 0.0013
  • ESR1
  • TP53
  • TRIM25
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Ductal breast carcinoma 0.0013
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Drug Metabolism
  • Endocrine System Development and Function
  • Lipid Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Secretion of beta-estradiol 0.00131
  • ESR1
  • IL6
  • Cell Cycle
 Arrest in G2/M phase of tumor cell lines 0.00131
  • IL6
  • PTEN
  • TP53
  • Nutritional Disease
  • Psychological Disorders
 Eating Disorders 0.00132
  • Cancer
  • Organismal Injury and Abnormalities
 Mixed neoplasia 0.00132
  • ESR1
  • FAM105A
  • GPR87
  • PCNA
  • PTEN
  • QRFPR
  • TMEM127
  • TP53
  • TRIM25
  • TSPAN9
  • Cell Cycle
 Cell cycle progression of stem cells 0.00133
  • PTEN
  • TP53
  • Molecular Transport
  • Small Molecule Biochemistry
 Transport of amphetamine 0.00138
  • Molecular Transport
 Transport of desipramine 0.00138
  • Molecular Transport
  • Small Molecule Biochemistry
 Transport of methamphetamine 0.00138
  • Cell Death and Survival
 Apoptosis of crypt cells 0.00138
  • ESR1
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Growth of soft tissue sarcoma 0.00139
  • IL6
  • TP53
  • Cell Morphology
 Shape change of melanoma cell lines 0.00141
  • IL6
  • TP53
  • Cellular Movement
 Cell movement of stem cells 0.00143
  • ESR1
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in cell cycle progression of tumor cell lines 0.00145
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in proliferation of leukemia cell lines 0.00145
  • IL6
  • TP53
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
 Cell death of mammary epithelial cells 0.00145
  • IL6
  • TP53
  • Cellular Growth and Proliferation
 Colony formation of melanoma cell lines 0.00148
  • PTEN
  • TP53
  • Hematological System Development and Function
  • Tissue Morphology
 Quantity of myeloid-derived suppressor cells 0.00148
  • IL6
  • TP53
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Disorder of epididymis 0.00149
  • ELAVL1
  • ESR1
  • PTEN
  • Skeletal and Muscular Disorders
 Abnormality of lower limb 0.00154
  • ESR1
  • GPR87
  • IL6
  • TP53
  • Cell-To-Cell Signaling and Interaction
 Gap junctional intercellular communication of cells 0.00155
  • ESR1
  • IL6
  • Cell Morphology
 Area of cells 0.00156
  • IL6
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 Excision repair 0.00158
  • Cell Death and Survival
  • Renal Necrosis/Cell Death
  • Renal and Urological System Development and Function
 Cell viability of kidney cell lines 0.00159
  • Cell Cycle
 Arrest in cell cycle progression of prostate cancer cell lines 0.00161
  • PTEN
  • TP53
  • Cell Cycle
 Delay in cell cycle progression of tumor cell lines 0.00161
  • PCNA
  • PTEN
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of prostate cancer cells 0.00163
  • PTEN
  • TP53
  • Cell Cycle
  • DNA Replication
  • Recombination
  • and Repair
 Checkpoint control of tumor cell lines 0.00163
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Metastasis of tumor cells 0.00164
  • PCNA
  • PTEN
  • TP53
  • Metabolic Disease
 Disorder of lipid metabolism 0.00164
  • ESR1
  • HTR2C
  • IL6
  • PTEN
  • TP53
  • Cellular Movement
 Cell movement of epithelial cells 0.00165
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Quantity of hepatocellular carcinoma 0.00167
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Invasive malignant bladder tumor 0.00168
  • PTEN
  • TP53
  • Cell Cycle
 Replicative senescence of cells 0.00169
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Medulloblastoma SHH subtype 0.0017
  • PTEN
  • TP53
  • Connective Tissue Disorders
  • Hereditary Disorder
  • Immunological Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Autoimmune interstitial lung, joint and kidney disease 0.00172
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Abnormality of gingiva 0.00174
  • IL6
  • PCNA
  • Cell Cycle
 Mitosis of breast cancer cell lines 0.00174
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Metastatic malignant neoplasm of prostate 0.00175
  • ESR1
  • PTEN
  • TP53
  • Embryonic Development
  • Organismal Development
  • Reproductive System Development and Function
 Development of female reproductive tract 0.00177
  • ESR1
  • PCNA
  • PTEN
  • TRIM25
  • Cell Morphology
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Tissue Development
 Size of fibroblast cell lines 0.00178
  • PTEN
  • TP53
  • Carbohydrate Metabolism
 Regulation of carbohydrate 0.0018
  • Cell Death and Survival
  • Nervous System Development and Function
 Survival of astrocytes 0.0018
  • PTEN
  • TP53
  • Connective Tissue Disorders
  • Developmental Disorder
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Kyphosis 0.00181
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in growth of breast cancer cell lines 0.00182
  • ESR1
  • PTEN
  • Cell Death and Survival
  • Skeletal and Muscular Disorders
 Apoptosis of vascular smooth muscle cells 0.00183
  • IL6
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
  • Organ Development
  • Reproductive System Development and Function
 Proliferation of endometrial cells 0.0019
  • ESR1
  • TRIM25
  • Cell Cycle
 Cell cycle progression of tumor cell lines 0.00191
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Preterm birth 0.00194
  • ESR1
  • IL6
  • Gene Expression
 Initiation of expression of RNA 0.00194
  • CTIF
  • ESR1
  • TP53
  • Embryonic Development
  • Nervous System Development and Function
  • Ophthalmic Disease
  • Organ Development
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Tissue Development
  • Visual System Development and Function
 Opacity of cornea 0.00198
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
 Development of thyroid gland tumor 0.002
  • PTEN
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Liver Enlargement
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hepatomegaly 0.00202
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 HER2 negative hormone receptor negative breast cancer 0.00202
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cell Death and Survival
 Cell death of bone marrow cell lines 0.00203
  • ESR1
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
  • Organ Development
  • Tissue Development
 Proliferation of splenocytes 0.00203
  • IL6
  • PTEN
  • TP53
  • Behavior
 Appetite 0.00206
  • Organismal Injury and Abnormalities
 Hamartoma 0.00215
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal carcinoma 0.00217
  • AZIN1
  • ESR1
  • PHTF2
  • PTEN
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Molecular Transport
  • Small Molecule Biochemistry
 Quantity of histamine 0.00217
  • Cell Death and Survival
 Cell death of gonadal cells 0.00223
  • ELAVL1
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Regression of malignant tumor 0.00223
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Grade 3-4 tumor 0.00224
  • ESR1
  • PTEN
  • TP53
  • Drug Metabolism
  • Endocrine System Development and Function
  • Lipid Metabolism
  • Small Molecule Biochemistry
  • Vitamin and Mineral Metabolism
 Synthesis of progesterone 0.00224
  • ESR1
  • IL6
  • TP53
  • Hematological System Development and Function
  • Immunological Disease
  • Lymphoid Tissue Structure and Development
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Abnormal morphology of enlarged thymus gland 0.00226
  • PTEN
  • TP53
  • Tissue Development
 Proliferation of epithelial tissue 0.00228
  • ESR1
  • PTEN
  • Cancer
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological Disease
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Proliferation of myeloma cells 0.0023
  • IL6
  • PTEN
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Hereditary cancer 0.00232
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
  • Tissue Development
 Proliferation of duct cells 0.00234
  • ESR1
  • IL6
  • Cellular Movement
 Migration of breast cancer cell lines 0.00241
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Reproductive System Disease
 Postpartum depression 0.00246
  • Reproductive System Development and Function
 Function of reproductive system 0.00247
  • ESR1
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
 Proliferation of Th17 cells 0.00248
  • ELAVL1
  • IL6
  • Cell Death and Survival
  • Embryonic Development
 Cell viability of embryonic stem cells 0.0025
  • PTEN
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Richter syndrome 0.0025
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of leukemia cells 0.00252
  • IL6
  • PTEN
  • TP53
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
  • Tissue Development
 Accumulation of regulatory T lymphocytes 0.00252
  • IL6
  • PTEN
  • Lipid Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Concentration of bile acid 0.00255
  • ESR1
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Development of breast adenocarcinoma 0.00255
  • ESR1
  • TP53
  • Cancer
  • Organismal Functions
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Inhibition of malignant tumor 0.00255
  • IL6
  • TP53
  • Respiratory System Development and Function
 Reactivity of airway 0.00257
  • IL6
  • PTEN
  • DNA Replication
  • Recombination
  • and Repair
 Repair of DNA 0.00261
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Hepatic steatosis 0.00261
  • ESR1
  • IL6
  • NEIL1
  • PTEN
  • TP53
  • Connective Tissue Development and Function
  • Skeletal and Muscular System Development and Function
  • Tissue Development
 Thickness of bone 0.00262
  • ESR1
  • IL6
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Activation of neurons 0.00264
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Schizoaffective disorder 0.00266
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Salivary duct carcinoma 0.00269
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
  • Nervous System Development and Function
 Proliferation of microglia 0.00274
  • IL6
  • TP53
  • Cell Cycle
 Arrest in G2/M phase transition of pancreatic cancer cell lines 0.00275
  • ELAVL1
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Delay in initiation of functional recovery of intestinal barrier 0.00275
  • ELAVL1
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Organismal Injury and Abnormalities
 Cholangiocarcinoma 0.00279
  • IL6
  • PTEN
  • TP53
  • Cellular Movement
 Cell movement of gonadal cells 0.0028
  • ESR1
  • PTEN
  • TP53
  • Cell Death and Survival
 Apoptosis of cervical cancer cell lines 0.00281
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Assembly and Organization
  • DNA Replication
  • Recombination
  • and Repair
 Formation of nuclear foci 0.00283
  • IL6
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organ Development
  • Skeletal and Muscular System Development and Function
  • Tissue Development
 Proliferation of smooth muscle cells 0.00287
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Nutritional Disease
 Adult-onset obesity 0.0029
  • Cell Cycle
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
 Contact growth inhibition of breast cancer cell lines 0.0029
  • ESR1
  • IL6
  • Dermatological Diseases and Conditions
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Angioedema 0.00298
  • Hematological System Development and Function
  • Nervous System Development and Function
  • Tissue Morphology
 Quantity of microglia 0.00298
  • IL6
  • TP53
  • Cell Death and Survival
 Cell death of spermatocytes 0.003
  • ELAVL1
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Development of hepatocellular carcinoma 0.00303
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
  • Gene Expression
 Binding of C/EBP binding site 0.00303
  • IL6
  • TP53
  • Behavior
 Stereotypy 0.00303
  • Cancer
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Development of pancreatic tumor 0.00305
  • PTEN
  • TP53
  • Cell Morphology
  • Cellular Assembly and Organization
 Mass of mitochondria 0.00305
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Endometrial serous carcinoma 0.00308
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Hematological System Development and Function
  • Hematopoiesis
  • Organismal Development
  • Tissue Development
 Differentiation of erythroid precursor cells 0.00309
  • IL6
  • PTEN
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 AA amyloidosis of liver 0.0031
  • IL6
  • Immunological Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 AA amyloidosis of spleen 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Activation of enteric neurons 0.0031
  • IL6
  • Inflammatory Response
 Acute phase reaction of hepatocytes 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Inflammatory Response
 Allostimulation of T lymphocytes 0.0031
  • IL6
  • Cellular Assembly and Organization
 Association of DNA damage focus 0.0031
  • PCNA
  • Cancer
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Ataxia-telangiectasia-like disorder type 2 0.0031
  • PCNA
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Atrophy of quadriceps muscle 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Cellular Assembly and Organization
  • Connective Tissue Development and Function
 Cell-cell contact of synovial cells 0.0031
  • IL6
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
 Cellular infiltration by inflammatory monocytes 0.0031
  • IL6
  • Cellular Development
 Differentiation of B lymphoblastoid cell lines 0.0031
  • IL6
  • Cell-mediated Immune Response
  • Cellular Development
  • Cellular Function and Maintenance
  • Cellular Growth and Proliferation
  • Embryonic Development
  • Hematological System Development and Function
  • Hematopoiesis
  • Lymphoid Tissue Structure and Development
  • Orga
 Differentiation of Th22 cells 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Small Molecule Biochemistry
 Downregulation of norepinephrine 0.0031
  • IL6
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Fibrosis of quadriceps muscle 0.0031
  • IL6
  • Tissue Development
 Growth of white matter 0.0031
  • IL6
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Hyperplasia of effector lymphocytes 0.0031
  • IL6
  • Endocrine System Disorders
  • Hematological Disease
 Hypozincemia 0.0031
  • IL6
  • Cellular Development
  • Hematological System Development and Function
 Inactivation of regulatory T lymphocytes 0.0031
  • IL6
  • Inflammatory Response
  • Skeletal and Muscular Disorders
 Inflammation of knee region 0.0031
  • IL6
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Inflammation of liver lobule 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Inflammatory Response
 Inflammatory response of peritoneal macrophages 0.0031
  • IL6
  • Cellular Growth and Proliferation
 Inhibition of hepatoma cell lines 0.0031
  • IL6
  • Connective Tissue Disorders
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Initiation of collagen-induced arthritis 0.0031
  • IL6
  • Cellular Movement
 Invasion of colon cell lines 0.0031
  • IL6
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Leukocytosis of plasma cells 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
 Mitogenic response of lymphocytes 0.0031
  • IL6
  • Gastrointestinal Disease
  • Inflammatory Disease
 Montreal B2 Crohn disease 0.0031
  • IL6
  • Cancer
  • Organismal Injury and Abnormalities
 Multicentric castleman disease 0.0031
  • IL6
  • Cardiovascular System Development and Function
  • Skeletal and Muscular System Development and Function
 Muscularization of arterial tree 0.0031
  • IL6
  • DNA Replication
  • Recombination
  • and Repair
 Mutagenesis of gene 0.0031
  • PCNA
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Infectious Diseases
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Opisthorchiasis periductal fibrosis 0.0031
  • IL6
  • Hematological Disease
  • Immunological Disease
  • Infectious Diseases
 Post transplant B-cell lymphoproliferative disorder 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
 Priming of TH17 lineage cells 0.0031
  • IL6
  • Cell Morphology
  • Connective Tissue Development and Function
 Projection of synovial cells 0.0031
  • IL6
  • Infectious Diseases
 Quantity of vaccinia virus 0.0031
  • IL6
  • Cell Death and Survival
 Recovery of hepatoma cell lines 0.0031
  • IL6
  • Organismal Functions
 Regulation of prostate gland 0.0031
  • IL6
  • Metabolic Disease
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Renal AA amyloidosis 0.0031
  • IL6
  • Cellular Response to Therapeutics
 Sensitivity of gonadal cell lines 0.0031
  • PCNA
  • Cancer
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Stimulation of acute myeloid leukemia blast cells 0.0031
  • IL6
  • Cell Death and Survival
  • Hematological System Development and Function
 Survival of Th17 cells 0.0031
  • IL6
  • Developmental Disorder
  • Gastrointestinal Disease
  • Inflammatory Disease
 Susceptibility to Crohn disease-associated growth failure 0.0031
  • IL6
  • Cardiovascular Disease
  • Developmental Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Susceptibility to intracranial hemorrhage in brain cerebrovascular malformations 0.0031
  • IL6
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Tumorigenesis of kidney cells 0.0031
  • IL6
  • Infectious Diseases
  • Respiratory Disease
 Bacterial respiratory infection 0.0031
  • IL6
  • PTEN
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Colonic polyp 0.00313
  • PTEN
  • TP53
  • Behavior
  • Reproductive System Development and Function
 Maternal behavior 0.00316
  • ESR1
  • PTEN
  • Cancer
  • Hematological Disease
  • Organismal Injury and Abnormalities
 Growth of hematological system tumor 0.00318
  • IL6
  • PTEN
  • TP53
  • Nutritional Disease
 Body mass index 0.00321
  • Cell Death and Survival
 Quantity of apoptotic cells 0.00321
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Familial brain tumor syndrome 0.00323
  • PTEN
  • TP53
  • Cell Morphology
  • Hematological System Development and Function
  • Nervous System Development and Function
 Morphology of microglia 0.00323
  • ESR1
  • IL6
  • Cardiac Necrosis/Cell Death
  • Cardiovascular Disease
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Apoptosis of cardiomyocytes 0.00364
  • ELAVL1
  • IL6
  • PTEN
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Biliary fibrosis 0.00378
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Degeneration
  • Organismal Injury and Abnormalities
 Degeneration of liver 0.0038
  • ESR1
  • IL6
  • Decreased Levels of Albumin
 Decreased Levels of Albumin 0.00426
  • IL6
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Delay in initiation of regression of hepatocellular carcinoma 0.00447
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Recurrent liver cancer 0.00447
  • TP53
  • Decreased Levels of Albumin
 Decreased production of albumin 0.00618
  • IL6
  • Increased Levels of CRP
 Increased synthesis of CRP 0.00618
  • IL6
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Regeneration
  • Organ Morphology
 Initiation of regeneration of liver 0.00618
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver cholangiocarcinoma 0.00633
  • PTEN
  • TP53
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Cell Morphology
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Skeletal and Muscular System Deve
 Hypertrophy of ventricular myocardium 0.00653
  • IL6
  • Liver Cirrhosis
 Cirrhosis 0.00702
  • ESR1
  • IL6
  • PCNA
  • TP53
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal and Urological Disease
 Lesioning of kidney 0.00755
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Hepatitis subtype infantile hepatitis syndrome 0.00824
  • IL6
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Infantile cholestatic hepatitis syndrome 0.00824
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Onset of development of liver tumor 0.00824
  • TP53
  • Cardiac Hemorrhaging
  • Cardiovascular Disease
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
 Bleeding of pericardium 0.00926
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Lesioning of liver 0.0096
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Liver Steatosis
  • Metabolic Disease
  • Organ Deve
 Steatohepatitis 0.0111
  • IL6
  • PTEN
  • Decreased Levels of Albumin
  • Molecular Transport
 Decreased secretion of albumin 0.0127
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hyperplasia of hepatocytes 0.0127
  • PTEN
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Cell Morphology
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hypertrophy of heart cells 0.0128
  • Decreased Levels of Albumin
 Decreased synthesis of albumin 0.013
  • IL6
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Cell death of sinusoidal endothelial cells 0.0134
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Failure
  • Organismal Injury and Abnormalities
 Failure of liver 0.014
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Proliferation
  • Organ Development
  • Tissue Development
 Proliferation of hepatocytes 0.0152
  • IL6
  • PTEN
  • TP53
  • Immunological Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Autoimmune glomerulonephritis 0.0156
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Renal Proliferation
  • Renal and Urological System Development and Function
 Cell proliferation of kidney cell lines 0.0167
  • ESR1
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Renal Proliferation
  • Renal and Urological System Development and Function
 Arrest in growth of kidney cell lines 0.0178
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Cirrhosis
  • Organismal Injury and Abnormalities
 Cirrhosis of liver 0.0179
  • IL6
  • PCNA
  • TP53
  • Decreased Levels of Albumin
 Decreased activation of albumin 0.0198
  • TP53
  • Cardiovascular Disease
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Reperfusion injury of liver 0.0201
  • PTEN
  • Increased Levels of Alkaline Phosphatase
 Increased activation of alkaline phosphatase 0.0233
  • ESR1
  • IL6
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Inflammation of liver 0.0233
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cardiac Proliferation
  • Cardiovascular System Development and Function
  • Cellular Development
  • Cellular Growth and Proliferation
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Skeletal and Muscular System Development and Function
  • Tissue
 Proliferation of cardiomyocytes 0.0268
  • IL6
  • PTEN
  • Increased Levels of ALT
 Increased release of ALT 0.0269
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Severe hepatic steatosis 0.0272
  • ESR1
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Cirrhosis
  • Organismal Injury and Abnormalities
 Compensated cirrhosis 0.0275
  • PCNA
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hypertrophy of heart 0.0283
  • Lipid Metabolism
  • Liver Cholestasis
  • Molecular Transport
  • Small Molecule Biochemistry
 Secretion of bile acid 0.0295
  • ESR1
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Susceptibility to myocardial infarction 0.0295
  • ESR1
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Cortical renal glomerulopathies 0.0305
  • ESR1
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Pyelonephritis 0.0366
  • IL6
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Myocardial infarction 0.0374
  • ELAVL1
  • ESR1
  • IL6
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Glomerulonephritis 0.038
  • ESR1
  • IL6
  • TP53
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Organismal Injury and Abnormalities
 Congenital heart disease 0.0414
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • DNA Replication
  • Recombination
  • and Repair
  • Developmental Disorder
  • Endocrine System Disorders
  • Hereditary Disorder
  • Immunological Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Skelet
 Shprintzen syndrome 0.0438
  • Biliary Hyperplasia
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organismal Development
  • Tissue Development
 Proliferation of cholangiocytes 0.0471
  • IL6
  • Glutathione Depletion In Liver
  • Liver Fibrosis
 Production of reactive oxygen species in liver 0.0475
  • PTEN
  • Cell Death and Survival
  • Cellular Development
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Regeneration
  • Organ Morphology
 Regeneration of liver cells 0.0475
  • IL6
  • Hepatic System Development and Function
  • Liver Proliferation
  • Organ Morphology
  • Tissue Morphology
 Quantity of hepatocytes 0.0537
  • TP53
  • Glutathione Depletion In Liver
 Quantity of glutathione in liver 0.0547
  • IL6
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Familial congenital heart disease 0.0554
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Necrosis of liver 0.0586
  • ESR1
  • IL6
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Microvesicular hepatic steatosis 0.0599
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Growth of hepatocellular carcinoma 0.0602
  • IL6
  • Cardiac Dysfunction
  • Cardiac Fibrosis
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Fibrosis of left ventricle 0.0654
  • ELAVL1
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Damage of liver 0.0667
  • IL6
  • PTEN
  • TP53
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Cell Morphology
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Skeletal and Muscular System Deve
 Hypertrophy of cardiomyocytes 0.0674
  • IL6
  • PTEN
  • Cardiac Dilation
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Idiopathic dilated cardiomyopathy 0.0705
  • IL6
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Right ventricular hypertrophy 0.0721
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Fibrosis of liver 0.0724
  • IL6
  • TP53
  • Increased Levels of ALT
 Increased localization of ALT 0.0744
  • IL6
  • Glomerular Injury
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Abnormal morphology of mesangial matrix 0.0753
  • ESR1
  • Cardiac Dysfunction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Dysfunction of left ventricle 0.0779
  • ELAVL1
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatoblastoma 0.0788
  • TP53
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Apoptosis of hepatocytes 0.0876
  • IL6
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Alcoholic hepatitis 0.088
  • IL6
  • Cardiac Necrosis/Cell Death
  • Cardiovascular System Development and Function
  • Cell Death and Survival
  • Skeletal and Muscular System Development and Function
 Cell viability of cardiomyocytes 0.088
  • PTEN
  • Cell Death and Survival
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Apoptosis of podocytes 0.0893
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatocellular adenoma 0.0927
  • PTEN
  • Immunological Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 IgA nephropathy 0.0937
  • TP53
  • Cardiac Necrosis/Cell Death
  • Cardiovascular Disease
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Apoptosis of ventricular myocytes 0.0996
  • TP53
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal and Urological Disease
 Damage of kidney 0.102
  • IL6
  • TP53
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Apoptosis of liver cell lines 0.104
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Infectious Diseases
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Damage
  • Liver Inflammation/Hepatitis
  • Organ Devel
 Chronic hepatitis B 0.107
  • IL6
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal Enlargement
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Hypertrophy of renal glomerulus 0.109
  • ESR1
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Double outlet right ventricle 0.111
  • TP53
  • Cardiac Damage
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Cardiotoxicity 0.118
  • ESR1
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal Tubule Injury
  • Renal and Urological Disease
 Damage of renal tubule 0.119
  • TP53
  • Increased Levels of Creatinine
 Increased Levels of Creatinine 0.129
  • IL6
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organ Development
  • Renal Proliferation
  • Renal and Urological System Development and Function
 Proliferation of mesangial cells 0.131
  • IL6
  • Cardiovascular System Development and Function
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Fibrosis
  • Liver
Proliferation of hepatic stellate cells 0.145
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Connective Tissue Development and Function
  • Hepatic System Development and Function
  • Liver Fibrosis
 Activation of hepatic stellate cells 0.155
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Hepatic injury 0.176
  • IL6
  • PTEN
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Infectious Diseases
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Damage
  • Liver Inflammation/Hepatitis
  • Organ Devel
 Chronic hepatitis C 0.185
  • IL6
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Apoptosis of kidney cell lines 0.189
  • ESR1
  • TP53
  • Cardiac Arteriopathy
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Coronary artery disease 0.196
  • ESR1
  • IL6
  • Increased Levels of Hematocrit
 Increased Levels of Hematocrit 0.208
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Cholestasis
 Cholestasis 0.21
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatocellular carcinoma 0.221
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Increased Levels of Red Blood Cells
 Increased Levels of Red Blood Cells 0.234
  • TP53
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Acute myocardial infarction 0.281
  • IL6
  • Cardiac Arrythmia
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Atrial fibrillation 0.293
  • IL6
  • Cardiac Congestive Cardiac Failure
  • Cardiovascular Disease
  • Heart Failure
  • Organismal Injury and Abnormalities
 Congestive heart failure 0.309
  • IL6
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal and Urological Disease
 Injury of kidney 0.323
  • IL6
  • Kidney Failure
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 End stage renal disease 0.331
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver carcinoma 1.0
  • COPA
  • ELAVL1
  • ESR1
  • GPR32
  • IL6
  • NEIL1
  • PTEN
  • TMEM127
  • TP53
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver tumor 1.0
  • CDC14B
  • COPA
  • ELAVL1
  • ESR1
  • FAM105A
  • FAM131A
  • GPR32
  • GPR87
  • HTR2C
  • IL6
  • NEIL1
  • PCNA
  • PHTF2
  • PTEN
  • QRFPR
  • TMEM127
  • TP53
  • TRIM25

Top Diseases and Functions: Cell Cycle, Hematological Disease, Neurological Disease.

Ingenuity Canonical Pathways
Ingenuity Canonical Pathways Ratio Molecules
ILK Signaling 0.0101
Semaphorin Signaling in Neurons 0.0189
Actin Nucleation by ARP-WASP Complex 0.0161
Glioma Invasiveness Signaling 0.013
Regulation of Actin-based Motility by Rho 0.0109
Sumoylation Pathway 0.0098
Cholecystokinin/Gastrin-mediated Signaling 0.00893
Virus Entry via Endocytic Pathways 0.0082
Sphingosine-1-phosphate Signaling 0.00775
Phagosome Formation 0.00763
HMGB1 Signaling 0.00719
Insulin Receptor Signaling 0.00654
Tec Kinase Signaling 0.00578
CXCR4 Signaling 0.00559
Germ Cell-Sertoli Cell Junction Signaling 0.00549
RhoGDI Signaling 0.00546
Hepatic Fibrosis / Hepatic Stellate Cell Activation 0.00524
IL-8 Signaling 0.00483
Endothelin-1 Signaling 0.00474
mTOR Signaling 0.00469
Thrombin Signaling 0.00463
Integrin Signaling 0.00455
Cardiac Hypertrophy Signaling 0.004
Phospholipase C Signaling 0.00397
Signaling by Rho Family GTPases 0.00394
Colorectal Cancer Metastasis Signaling 0.00386
Ingenuity Canonical Biological Processes
Category Disease, Function Annotation p-Value Molecules
  • Cell Cycle
  • Embryonic Development
 Entry into senescence of embryonic cell lines 1.34E-7
  • Cell Cycle
  • Cellular Development
  • Connective Tissue Development and Function
 Entry into senescence of fibroblast cell lines 1.34E-7
  • Cellular Growth and Proliferation
 Cytostasis of breast cancer cell lines 1.43E-5
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Compromise
 Breakdown of lysosome 2.64E-5
  • IL6
  • TP53
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
  • Tissue Morphology
 Quantity of Th17 cells 2.95E-5
  • ELAVL1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of lung cancer cells 3.07E-5
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
 Cell cycle progression of breast cancer cell lines 3.25E-5
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Behavior
 Aggressive behavior toward males 3.45E-5
  • ESR1
  • IL6
  • PTEN
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Growth of mammary tumor 3.84E-5
  • ELAVL1
  • ESR1
  • PTEN
  • TP53
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal tumor 4.05E-5
  • AZIN1
  • ESR1
  • IL6
  • PCNA
  • PHTF2
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 Formation of DNA fragment 4.64E-5
  • PCNA
  • TP53
  • Cell Death and Survival
 Recovery of tumor cell lines 4.97E-5
  • IL6
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Large-cell follicular lymphoma 5.66E-5
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Adenoid cystic carcinoma 6.08E-5
  • ESR1
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in G0/G1 phase transition 6.25E-5
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
  • Cellular Development
  • Connective Tissue Development and Function
 Senescence of fibroblast cell lines 6.36E-5
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Testicular teratoma 7.18E-5
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 DNA damage 7.82E-5
  • Organismal Injury and Abnormalities
 Plasmacytosis 8.44E-5
  • ESR1
  • IL6
  • Cell Cycle
 G1/S phase transition of breast cancer cell lines 8.68E-5
  • ELAVL1
  • ESR1
  • TP53
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Reproductive System Development and Function
  • Reproductive System Disease
 Abnormal morphology of uterus 9.61E-5
  • ELAVL1
  • ESR1
  • PTEN
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Tumorigenesis of salivary gland tumor 1.13E-4
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Autosomal dominant breast cancer 1.18E-4
  • ESR1
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 WHO grade IV malignant astrocytoma 1.18E-4
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in cell cycle progression of breast cancer cell lines 1.24E-4
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Familial sarcoma 1.28E-4
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Invasive adenocarcinoma 1.29E-4
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in G1 phase of bladder cancer cell lines 1.34E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Tumorigenesis of prostatic intraepithelial tumor 1.34E-4
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
 Apoptosis of carcinoma 1.45E-4
  • IL6
  • PTEN
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Hereditary tumor 1.46E-4
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TMEM127
  • TP53
  • Cell Cycle
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
 Contact growth inhibition of tumor cell lines 1.48E-4
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
 Transformation of kidney cell lines 1.55E-4
  • ESR1
  • PTEN
  • TP53
  • Connective Tissue Disorders
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Experimentally-induced arthritis of ankle joint 1.57E-4
  • IL6
  • PTEN
  • Cell Cycle
 Delay in cell cycle progression 1.86E-4
  • IL6
  • PCNA
  • PTEN
  • Cell Death and Survival
 Apoptosis of salivary mucous cells 1.94E-4
  • ESR1
  • TP53
  • Cancer
 Transformation of lung cell lines 1.94E-4
  • IL6
  • TP53
  • Lymphoid Tissue Structure and Development
  • Tissue Morphology
 Quantity of bone marrow cells 1.98E-4
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Oropharyngeal tumor 1.98E-4
  • IL6
  • PCNA
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Frontal lobe astrocytoma 2.08E-4
  • PTEN
  • TP53
  • Cell Cycle
  • Embryonic Development
 G1 phase of embryonic stem cells 2.14E-4
  • PTEN
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of large-cell lymphoma 2.21E-4
  • IL6
  • TP53
  • Cell Cycle
 Arrest in G0/G1 phase transition of tumor cell lines 2.28E-4
  • IL6
  • PTEN
  • TP53
  • Biliary Hyperplasia
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Organismal Injury and Abnormalities
 Development of cholangiocarcinoma 2.36E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
  • Tissue Morphology
 Quantity of genital tumor 2.36E-4
  • PTEN
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Glioma susceptibility 2.43E-4
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in growth of melanoma cell lines 2.58E-4
  • IL6
  • TP53
  • Cell Death and Survival
 Apoptosis of lymphoblastoid cell lines 2.58E-4
  • IL6
  • PCNA
  • TP53
  • Cell Cycle
 Interphase of breast cancer cell lines 2.61E-4
  • ELAVL1
  • ESR1
  • IL6
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Parietal lobe astrocytoma 2.66E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Fibroma 2.69E-4
  • ESR1
  • PCNA
  • PTEN
  • TP53
  • Cancer
  • Cell-To-Cell Signaling and Interaction
  • Inflammatory Response
 Cytotoxic reaction of tumor cell lines 2.69E-4
  • IL6
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Tissue Development
  • Tissue Morphology
 Expansion of epithelial stem cells 2.73E-4
  • PTEN
  • TP53
  • Organ Development
 Function of thymus gland 2.73E-4
  • ESR1
  • TP53
  • Cell Cycle
 Cell cycle progression of bone marrow cell lines 2.81E-4
  • ESR1
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Drug Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Concentration of dopamine 2.9E-4
  • DNA Replication
  • Recombination
  • and Repair
 Cleavage of DNA 2.91E-4
  • Cell Morphology
 Morphology of melanoma cell lines 3.14E-4
  • IL6
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of non-Hodgkin lymphoma 3.22E-4
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
  • Gene Expression
 Binding of TATA box 3.22E-4
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Respiratory Disease
  • Tumor Morphology
 Progression of lung tumor 3.22E-4
  • IL6
  • TP53
  • Tissue Development
 Development of organoid 3.31E-4
  • PTEN
  • TP53
  • Cell Cycle
 G1/S phase transition of tumor cell lines 3.36E-4
  • ELAVL1
  • ESR1
  • IL6
  • TP53
  • Cell Cycle
 Aneuploidy of splenocytes 3.39E-4
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal cancer 3.42E-4
  • AZIN1
  • ESR1
  • IL6
  • PHTF2
  • PTEN
  • TP53
  • Organ Development
  • Reproductive System Development and Function
 Ovulation of ovary 3.57E-4
  • ESR1
  • IL6
  • Gene Expression
 Expression of mRNA 3.71E-4
  • CTIF
  • ELAVL1
  • ESR1
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Growth of adenocarcinoma 3.73E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Development of myosarcoma 3.84E-4
  • PTEN
  • TP53
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Damage of brain 3.89E-4
  • ESR1
  • IL6
  • NEIL1
  • PTEN
  • TP53
  • Cancer
  • Cell Cycle
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Senescence of cancer cells 3.93E-4
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Hereditary breast cancer 3.98E-4
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Cell viability of lung cancer cells 4.32E-4
  • PTEN
  • TP53
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Growth of medulloblastoma 4.32E-4
  • PTEN
  • TP53
  • Organismal Injury and Abnormalities
 Premalignant lesion 4.32E-4
  • ESR1
  • PTEN
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Skeletal and Muscular System Development and Function
 Stimulation of smooth muscle cells 4.41E-4
  • IL6
  • PTEN
  • Small Molecule Biochemistry
 Synthesis of nitrite 4.53E-4
  • IL6
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
 Cytostasis of cervical cancer cell lines 4.61E-4
  • IL6
  • TP53
  • Cell Cycle
  • Gene Expression
 Binding of thyroid hormone response element 4.72E-4
  • ESR1
  • TP53
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
 Colony formation of colony-forming units granulocytes 4.72E-4
  • ESR1
  • IL6
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Temporal lobe astrocytoma 4.82E-4
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
 Cytostasis of melanoma cell lines 4.92E-4
  • IL6
  • TP53
  • Cell Cycle
 Arrest in G2 phase of tumor cell lines 5.02E-4
  • ELAVL1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Fibroadenoma 5.03E-4
  • ESR1
  • PTEN
  • Cell Cycle
 Senescence of lymphatic system cells 5.13E-4
  • PTEN
  • TP53
  • Organ Morphology
  • Organismal Development
  • Reproductive System Development and Function
  • Tissue Morphology
 Quantity of sperm 5.3E-4
  • ESR1
  • IL6
  • TP53
  • Cell Cycle
  • Connective Tissue Development and Function
 Arrest in G0/G1 phase transition of fibroblast cell lines 5.35E-4
  • ESR1
  • TP53
  • Organ Development
  • Reproductive System Development and Function
 Growth of genital organ 5.58E-4
  • ESR1
  • PTEN
  • TP53
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal squamous cell carcinoma 5.63E-4
  • Cell Death and Survival
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Apoptosis of neural precursor cells 5.68E-4
  • PTEN
  • TP53
  • Cell Morphology
  • Connective Tissue Development and Function
  • Tissue Morphology
 Area of connective tissue cells 5.68E-4
  • IL6
  • TP53
  • Cancer
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Lymphatic node tumor 5.79E-4
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Development of melanoma 5.81E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Invasive ductal breast carcinoma 5.88E-4
  • ESR1
  • IL6
  • PCNA
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of diffuse lymphoma 6.13E-4
  • IL6
  • TP53
  • Cancer
  • Endocrine System Disorders
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Pheochromocytoma 6.14E-4
  • PTEN
  • TMEM127
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Development of papillary carcinoma 6.49E-4
  • PTEN
  • TP53
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Reproductive System Development and Function
  • Reproductive System Disease
 Abnormal morphology of small uterus 6.61E-4
  • ESR1
  • TRIM25
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in proliferation of tumor cell lines 6.72E-4
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Salivary gland tumor 6.83E-4
  • IL6
  • PTEN
  • TP53
  • Connective Tissue Development and Function
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Skeletal and Muscular System Development and Function
  • Tissue Development
  • Tissue Morphology
 Loss of bone tissue 6.97E-4
  • ESR1
  • IL6
  • Cell Death and Survival
 Cell viability of stem cells 6.99E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Development of B-cell non-Hodgkin lymphoma 7.22E-4
  • IL6
  • TP53
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Reproductive System Development and Function
  • Tissue Development
 Formation of primordial ovarian follicle 7.22E-4
  • ESR1
  • PCNA
  • Cancer
  • Organismal Injury and Abnormalities
 Growth of squamous-cell carcinoma 7.48E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Infiltrating duct and lobular carcinoma 7.48E-4
  • ESR1
  • TP53
  • Cell Cycle
 G1/S phase transition 7.56E-4
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 Breakage of DNA 7.73E-4
  • PCNA
  • PTEN
  • TP53
  • Cell Cycle
 Cell cycle progression of lymphoblastoid cell lines 7.73E-4
  • IL6
  • PCNA
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Familial lung cancer 7.73E-4
  • PTEN
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Drug Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Abnormal quantity of dopamine 8.26E-4
  • Cancer
  • Organismal Injury and Abnormalities
 Metaplastic carcinoma 8.4E-4
  • PTEN
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Abnormal morphology of liver 8.61E-4
  • ESR1
  • IL6
  • NEIL1
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Embryonic Development
  • Organismal Development
  • Tissue Development
 Proliferation of neural stem cells 8.62E-4
  • IL6
  • PTEN
  • TP53
  • Cell Death and Survival
 Apoptosis of B lymphoblastoid cell lines 8.81E-4
  • IL6
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Cellular Movement
 Recruitment of muscle cells 8.81E-4
  • IL6
  • PTEN
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Tumorigenesis of prostatic carcinoma 8.81E-4
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Invasive breast carcinoma 8.93E-4
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Humoral Immune Response
  • Lymphoid Tissue Structure and Development
  • Tissue Morphology
 Quantity of germinal center 8.94E-4
  • ESR1
  • IL6
  • PTEN
  • Cell Cycle
  • DNA Replication
  • Recombination
  • and Repair
 Homologous recombination of chromosomes 8.95E-4
  • PTEN
  • TP53
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Skeletal and Muscular Disorders
 Parkinson's disease 9.2E-4
  • CTIF
  • HTR2C
  • IL6
  • PCNA
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in proliferation of lung cancer cell lines 9.37E-4
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Hematopoiesis
 Colony formation of macrophages 9.51E-4
  • ESR1
  • IL6
  • Cancer
  • Organismal Functions
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Inhibition of tumor 9.56E-4
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Metastasis of adenocarcinoma 9.95E-4
  • PTEN
  • TP53
  • Cellular Function and Maintenance
 Cell saturation density 0.00101
  • PTEN
  • TP53
  • Cell Death and Survival
 Cell viability of lymphoblastoid cell lines 0.00107
  • PCNA
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Leiomyosarcoma 0.00108
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Atypical endometrial hyperplasia 0.00108
  • ESR1
  • PTEN
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Large cell neuroendocrine lung carcinoma 0.0011
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in G1 phase of prostate cancer cell lines 0.00115
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Tumorigenesis of intestinal polyp 0.00116
  • PTEN
  • TP53
  • Cell Cycle
 G1 phase of tumor cell lines 0.00116
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Development of mammary tumor 0.00117
  • ESR1
  • PCNA
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Quantity of adenocarcinoma 0.00118
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Papillary renal cell carcinoma type 1 0.00121
  • PTEN
  • TP53
  • Protein Synthesis
 Quantity of cytokine 0.00122
  • Cell Cycle
 Arrest in G1 phase of leukemia cell lines 0.00124
  • IL6
  • TP53
  • Cellular Compromise
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Damage of axons 0.00124
  • IL6
  • PTEN
  • Cellular Compromise
 Stress response of embryonic cell lines 0.00128
  • Cancer
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
  • Tumor Morphology
 Proliferation of mammary tumor cells 0.0013
  • ESR1
  • TP53
  • TRIM25
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Ductal breast carcinoma 0.0013
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Drug Metabolism
  • Endocrine System Development and Function
  • Lipid Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Secretion of beta-estradiol 0.00131
  • ESR1
  • IL6
  • Cell Cycle
 Arrest in G2/M phase of tumor cell lines 0.00131
  • IL6
  • PTEN
  • TP53
  • Nutritional Disease
  • Psychological Disorders
 Eating Disorders 0.00132
  • Cancer
  • Organismal Injury and Abnormalities
 Mixed neoplasia 0.00132
  • ESR1
  • FAM105A
  • GPR87
  • PCNA
  • PTEN
  • QRFPR
  • TMEM127
  • TP53
  • TRIM25
  • TSPAN9
  • Cell Cycle
 Cell cycle progression of stem cells 0.00133
  • PTEN
  • TP53
  • Molecular Transport
  • Small Molecule Biochemistry
 Transport of amphetamine 0.00138
  • Molecular Transport
 Transport of desipramine 0.00138
  • Molecular Transport
  • Small Molecule Biochemistry
 Transport of methamphetamine 0.00138
  • Cell Death and Survival
 Apoptosis of crypt cells 0.00138
  • ESR1
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Growth of soft tissue sarcoma 0.00139
  • IL6
  • TP53
  • Cell Morphology
 Shape change of melanoma cell lines 0.00141
  • IL6
  • TP53
  • Cellular Movement
 Cell movement of stem cells 0.00143
  • ESR1
  • PTEN
  • TP53
  • Cell Cycle
 Arrest in cell cycle progression of tumor cell lines 0.00145
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in proliferation of leukemia cell lines 0.00145
  • IL6
  • TP53
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
 Cell death of mammary epithelial cells 0.00145
  • IL6
  • TP53
  • Cellular Growth and Proliferation
 Colony formation of melanoma cell lines 0.00148
  • PTEN
  • TP53
  • Hematological System Development and Function
  • Tissue Morphology
 Quantity of myeloid-derived suppressor cells 0.00148
  • IL6
  • TP53
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Disorder of epididymis 0.00149
  • ELAVL1
  • ESR1
  • PTEN
  • Skeletal and Muscular Disorders
 Abnormality of lower limb 0.00154
  • ESR1
  • GPR87
  • IL6
  • TP53
  • Cell-To-Cell Signaling and Interaction
 Gap junctional intercellular communication of cells 0.00155
  • ESR1
  • IL6
  • Cell Morphology
 Area of cells 0.00156
  • IL6
  • PTEN
  • TP53
  • DNA Replication
  • Recombination
  • and Repair
 Excision repair 0.00158
  • Cell Death and Survival
  • Renal Necrosis/Cell Death
  • Renal and Urological System Development and Function
 Cell viability of kidney cell lines 0.00159
  • Cell Cycle
 Arrest in cell cycle progression of prostate cancer cell lines 0.00161
  • PTEN
  • TP53
  • Cell Cycle
 Delay in cell cycle progression of tumor cell lines 0.00161
  • PCNA
  • PTEN
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of prostate cancer cells 0.00163
  • PTEN
  • TP53
  • Cell Cycle
  • DNA Replication
  • Recombination
  • and Repair
 Checkpoint control of tumor cell lines 0.00163
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Metastasis of tumor cells 0.00164
  • PCNA
  • PTEN
  • TP53
  • Metabolic Disease
 Disorder of lipid metabolism 0.00164
  • ESR1
  • HTR2C
  • IL6
  • PTEN
  • TP53
  • Cellular Movement
 Cell movement of epithelial cells 0.00165
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Quantity of hepatocellular carcinoma 0.00167
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Invasive malignant bladder tumor 0.00168
  • PTEN
  • TP53
  • Cell Cycle
 Replicative senescence of cells 0.00169
  • Cancer
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Medulloblastoma SHH subtype 0.0017
  • PTEN
  • TP53
  • Connective Tissue Disorders
  • Hereditary Disorder
  • Immunological Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Autoimmune interstitial lung, joint and kidney disease 0.00172
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Abnormality of gingiva 0.00174
  • IL6
  • PCNA
  • Cell Cycle
 Mitosis of breast cancer cell lines 0.00174
  • IL6
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Metastatic malignant neoplasm of prostate 0.00175
  • ESR1
  • PTEN
  • TP53
  • Embryonic Development
  • Organismal Development
  • Reproductive System Development and Function
 Development of female reproductive tract 0.00177
  • ESR1
  • PCNA
  • PTEN
  • TRIM25
  • Cell Morphology
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Tissue Development
 Size of fibroblast cell lines 0.00178
  • PTEN
  • TP53
  • Carbohydrate Metabolism
 Regulation of carbohydrate 0.0018
  • Cell Death and Survival
  • Nervous System Development and Function
 Survival of astrocytes 0.0018
  • PTEN
  • TP53
  • Connective Tissue Disorders
  • Developmental Disorder
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Kyphosis 0.00181
  • Cellular Development
  • Cellular Growth and Proliferation
 Arrest in growth of breast cancer cell lines 0.00182
  • ESR1
  • PTEN
  • Cell Death and Survival
  • Skeletal and Muscular Disorders
 Apoptosis of vascular smooth muscle cells 0.00183
  • IL6
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
  • Organ Development
  • Reproductive System Development and Function
 Proliferation of endometrial cells 0.0019
  • ESR1
  • TRIM25
  • Cell Cycle
 Cell cycle progression of tumor cell lines 0.00191
  • ESR1
  • IL6
  • PCNA
  • PTEN
  • TP53
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Preterm birth 0.00194
  • ESR1
  • IL6
  • Gene Expression
 Initiation of expression of RNA 0.00194
  • CTIF
  • ESR1
  • TP53
  • Embryonic Development
  • Nervous System Development and Function
  • Ophthalmic Disease
  • Organ Development
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Tissue Development
  • Visual System Development and Function
 Opacity of cornea 0.00198
  • Cancer
  • Endocrine System Disorders
  • Organismal Injury and Abnormalities
 Development of thyroid gland tumor 0.002
  • PTEN
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Liver Enlargement
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hepatomegaly 0.00202
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 HER2 negative hormone receptor negative breast cancer 0.00202
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cell Death and Survival
 Cell death of bone marrow cell lines 0.00203
  • ESR1
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
  • Organ Development
  • Tissue Development
 Proliferation of splenocytes 0.00203
  • IL6
  • PTEN
  • TP53
  • Behavior
 Appetite 0.00206
  • Organismal Injury and Abnormalities
 Hamartoma 0.00215
  • PTEN
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
  • Respiratory Disease
 Pharyngeal carcinoma 0.00217
  • AZIN1
  • ESR1
  • PHTF2
  • PTEN
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Molecular Transport
  • Small Molecule Biochemistry
 Quantity of histamine 0.00217
  • Cell Death and Survival
 Cell death of gonadal cells 0.00223
  • ELAVL1
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Regression of malignant tumor 0.00223
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
 Grade 3-4 tumor 0.00224
  • ESR1
  • PTEN
  • TP53
  • Drug Metabolism
  • Endocrine System Development and Function
  • Lipid Metabolism
  • Small Molecule Biochemistry
  • Vitamin and Mineral Metabolism
 Synthesis of progesterone 0.00224
  • ESR1
  • IL6
  • TP53
  • Hematological System Development and Function
  • Immunological Disease
  • Lymphoid Tissue Structure and Development
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Tissue Morphology
 Abnormal morphology of enlarged thymus gland 0.00226
  • PTEN
  • TP53
  • Tissue Development
 Proliferation of epithelial tissue 0.00228
  • ESR1
  • PTEN
  • Cancer
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological Disease
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Proliferation of myeloma cells 0.0023
  • IL6
  • PTEN
  • Cancer
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Hereditary cancer 0.00232
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Growth and Proliferation
  • Tissue Development
 Proliferation of duct cells 0.00234
  • ESR1
  • IL6
  • Cellular Movement
 Migration of breast cancer cell lines 0.00241
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Organismal Injury and Abnormalities
  • Psychological Disorders
  • Reproductive System Disease
 Postpartum depression 0.00246
  • Reproductive System Development and Function
 Function of reproductive system 0.00247
  • ESR1
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
 Proliferation of Th17 cells 0.00248
  • ELAVL1
  • IL6
  • Cell Death and Survival
  • Embryonic Development
 Cell viability of embryonic stem cells 0.0025
  • PTEN
  • TP53
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Richter syndrome 0.0025
  • PTEN
  • TP53
  • Cancer
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Apoptosis of leukemia cells 0.00252
  • IL6
  • PTEN
  • TP53
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
  • Tissue Development
 Accumulation of regulatory T lymphocytes 0.00252
  • IL6
  • PTEN
  • Lipid Metabolism
  • Molecular Transport
  • Small Molecule Biochemistry
 Concentration of bile acid 0.00255
  • ESR1
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Development of breast adenocarcinoma 0.00255
  • ESR1
  • TP53
  • Cancer
  • Organismal Functions
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Inhibition of malignant tumor 0.00255
  • IL6
  • TP53
  • Respiratory System Development and Function
 Reactivity of airway 0.00257
  • IL6
  • PTEN
  • DNA Replication
  • Recombination
  • and Repair
 Repair of DNA 0.00261
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Hepatic steatosis 0.00261
  • ESR1
  • IL6
  • NEIL1
  • PTEN
  • TP53
  • Connective Tissue Development and Function
  • Skeletal and Muscular System Development and Function
  • Tissue Development
 Thickness of bone 0.00262
  • ESR1
  • IL6
  • TP53
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Activation of neurons 0.00264
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Psychological Disorders
 Schizoaffective disorder 0.00266
  • Cancer
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Salivary duct carcinoma 0.00269
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Lymphoid Tissue Structure and Development
  • Nervous System Development and Function
 Proliferation of microglia 0.00274
  • IL6
  • TP53
  • Cell Cycle
 Arrest in G2/M phase transition of pancreatic cancer cell lines 0.00275
  • ELAVL1
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Delay in initiation of functional recovery of intestinal barrier 0.00275
  • ELAVL1
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Organismal Injury and Abnormalities
 Cholangiocarcinoma 0.00279
  • IL6
  • PTEN
  • TP53
  • Cellular Movement
 Cell movement of gonadal cells 0.0028
  • ESR1
  • PTEN
  • TP53
  • Cell Death and Survival
 Apoptosis of cervical cancer cell lines 0.00281
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cellular Assembly and Organization
  • DNA Replication
  • Recombination
  • and Repair
 Formation of nuclear foci 0.00283
  • IL6
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organ Development
  • Skeletal and Muscular System Development and Function
  • Tissue Development
 Proliferation of smooth muscle cells 0.00287
  • ELAVL1
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Nutritional Disease
 Adult-onset obesity 0.0029
  • Cell Cycle
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
 Contact growth inhibition of breast cancer cell lines 0.0029
  • ESR1
  • IL6
  • Dermatological Diseases and Conditions
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Angioedema 0.00298
  • Hematological System Development and Function
  • Nervous System Development and Function
  • Tissue Morphology
 Quantity of microglia 0.00298
  • IL6
  • TP53
  • Cell Death and Survival
 Cell death of spermatocytes 0.003
  • ELAVL1
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Development of hepatocellular carcinoma 0.00303
  • IL6
  • PTEN
  • TP53
  • Cell Cycle
  • Gene Expression
 Binding of C/EBP binding site 0.00303
  • IL6
  • TP53
  • Behavior
 Stereotypy 0.00303
  • Cancer
  • Endocrine System Disorders
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Development of pancreatic tumor 0.00305
  • PTEN
  • TP53
  • Cell Morphology
  • Cellular Assembly and Organization
 Mass of mitochondria 0.00305
  • PTEN
  • TP53
  • Cancer
  • Organismal Injury and Abnormalities
  • Reproductive System Disease
 Endometrial serous carcinoma 0.00308
  • PTEN
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Hematological System Development and Function
  • Hematopoiesis
  • Organismal Development
  • Tissue Development
 Differentiation of erythroid precursor cells 0.00309
  • IL6
  • PTEN
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 AA amyloidosis of liver 0.0031
  • IL6
  • Immunological Disease
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 AA amyloidosis of spleen 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Nervous System Development and Function
 Activation of enteric neurons 0.0031
  • IL6
  • Inflammatory Response
 Acute phase reaction of hepatocytes 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Hematological System Development and Function
  • Inflammatory Response
 Allostimulation of T lymphocytes 0.0031
  • IL6
  • Cellular Assembly and Organization
 Association of DNA damage focus 0.0031
  • PCNA
  • Cancer
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Ataxia-telangiectasia-like disorder type 2 0.0031
  • PCNA
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Atrophy of quadriceps muscle 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Cellular Assembly and Organization
  • Connective Tissue Development and Function
 Cell-cell contact of synovial cells 0.0031
  • IL6
  • Cellular Movement
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
 Cellular infiltration by inflammatory monocytes 0.0031
  • IL6
  • Cellular Development
 Differentiation of B lymphoblastoid cell lines 0.0031
  • IL6
  • Cell-mediated Immune Response
  • Cellular Development
  • Cellular Function and Maintenance
  • Cellular Growth and Proliferation
  • Embryonic Development
  • Hematological System Development and Function
  • Hematopoiesis
  • Lymphoid Tissue Structure and Development
  • Orga
 Differentiation of Th22 cells 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Small Molecule Biochemistry
 Downregulation of norepinephrine 0.0031
  • IL6
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Fibrosis of quadriceps muscle 0.0031
  • IL6
  • Tissue Development
 Growth of white matter 0.0031
  • IL6
  • Cancer
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Hyperplasia of effector lymphocytes 0.0031
  • IL6
  • Endocrine System Disorders
  • Hematological Disease
 Hypozincemia 0.0031
  • IL6
  • Cellular Development
  • Hematological System Development and Function
 Inactivation of regulatory T lymphocytes 0.0031
  • IL6
  • Inflammatory Response
  • Skeletal and Muscular Disorders
 Inflammation of knee region 0.0031
  • IL6
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Inflammation of liver lobule 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Inflammatory Response
 Inflammatory response of peritoneal macrophages 0.0031
  • IL6
  • Cellular Growth and Proliferation
 Inhibition of hepatoma cell lines 0.0031
  • IL6
  • Connective Tissue Disorders
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Initiation of collagen-induced arthritis 0.0031
  • IL6
  • Cellular Movement
 Invasion of colon cell lines 0.0031
  • IL6
  • Hematological Disease
  • Immunological Disease
  • Organismal Injury and Abnormalities
 Leukocytosis of plasma cells 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
 Mitogenic response of lymphocytes 0.0031
  • IL6
  • Gastrointestinal Disease
  • Inflammatory Disease
 Montreal B2 Crohn disease 0.0031
  • IL6
  • Cancer
  • Organismal Injury and Abnormalities
 Multicentric castleman disease 0.0031
  • IL6
  • Cardiovascular System Development and Function
  • Skeletal and Muscular System Development and Function
 Muscularization of arterial tree 0.0031
  • IL6
  • DNA Replication
  • Recombination
  • and Repair
 Mutagenesis of gene 0.0031
  • PCNA
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Infectious Diseases
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Opisthorchiasis periductal fibrosis 0.0031
  • IL6
  • Hematological Disease
  • Immunological Disease
  • Infectious Diseases
 Post transplant B-cell lymphoproliferative disorder 0.0031
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Hematological System Development and Function
  • Immune Cell Trafficking
  • Inflammatory Response
 Priming of TH17 lineage cells 0.0031
  • IL6
  • Cell Morphology
  • Connective Tissue Development and Function
 Projection of synovial cells 0.0031
  • IL6
  • Infectious Diseases
 Quantity of vaccinia virus 0.0031
  • IL6
  • Cell Death and Survival
 Recovery of hepatoma cell lines 0.0031
  • IL6
  • Organismal Functions
 Regulation of prostate gland 0.0031
  • IL6
  • Metabolic Disease
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Renal AA amyloidosis 0.0031
  • IL6
  • Cellular Response to Therapeutics
 Sensitivity of gonadal cell lines 0.0031
  • PCNA
  • Cancer
  • Cell-To-Cell Signaling and Interaction
  • Cellular Growth and Proliferation
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Stimulation of acute myeloid leukemia blast cells 0.0031
  • IL6
  • Cell Death and Survival
  • Hematological System Development and Function
 Survival of Th17 cells 0.0031
  • IL6
  • Developmental Disorder
  • Gastrointestinal Disease
  • Inflammatory Disease
 Susceptibility to Crohn disease-associated growth failure 0.0031
  • IL6
  • Cardiovascular Disease
  • Developmental Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Susceptibility to intracranial hemorrhage in brain cerebrovascular malformations 0.0031
  • IL6
  • Cancer
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Tumorigenesis of kidney cells 0.0031
  • IL6
  • Infectious Diseases
  • Respiratory Disease
 Bacterial respiratory infection 0.0031
  • IL6
  • PTEN
  • Gastrointestinal Disease
  • Organismal Injury and Abnormalities
 Colonic polyp 0.00313
  • PTEN
  • TP53
  • Behavior
  • Reproductive System Development and Function
 Maternal behavior 0.00316
  • ESR1
  • PTEN
  • Cancer
  • Hematological Disease
  • Organismal Injury and Abnormalities
 Growth of hematological system tumor 0.00318
  • IL6
  • PTEN
  • TP53
  • Nutritional Disease
 Body mass index 0.00321
  • Cell Death and Survival
 Quantity of apoptotic cells 0.00321
  • ESR1
  • PTEN
  • TP53
  • Cancer
  • Hereditary Disorder
  • Neurological Disease
  • Organismal Injury and Abnormalities
 Familial brain tumor syndrome 0.00323
  • PTEN
  • TP53
  • Cell Morphology
  • Hematological System Development and Function
  • Nervous System Development and Function
 Morphology of microglia 0.00323
  • ESR1
  • IL6
  • Cardiac Necrosis/Cell Death
  • Cardiovascular Disease
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Apoptosis of cardiomyocytes 0.00364
  • ELAVL1
  • IL6
  • PTEN
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Biliary fibrosis 0.00378
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Degeneration
  • Organismal Injury and Abnormalities
 Degeneration of liver 0.0038
  • ESR1
  • IL6
  • Decreased Levels of Albumin
 Decreased Levels of Albumin 0.00426
  • IL6
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
  • Tumor Morphology
 Delay in initiation of regression of hepatocellular carcinoma 0.00447
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Recurrent liver cancer 0.00447
  • TP53
  • Decreased Levels of Albumin
 Decreased production of albumin 0.00618
  • IL6
  • Increased Levels of CRP
 Increased synthesis of CRP 0.00618
  • IL6
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Regeneration
  • Organ Morphology
 Initiation of regeneration of liver 0.00618
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver cholangiocarcinoma 0.00633
  • PTEN
  • TP53
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Cell Morphology
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Skeletal and Muscular System Deve
 Hypertrophy of ventricular myocardium 0.00653
  • IL6
  • Liver Cirrhosis
 Cirrhosis 0.00702
  • ESR1
  • IL6
  • PCNA
  • TP53
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal and Urological Disease
 Lesioning of kidney 0.00755
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Hepatitis subtype infantile hepatitis syndrome 0.00824
  • IL6
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Infantile cholestatic hepatitis syndrome 0.00824
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Onset of development of liver tumor 0.00824
  • TP53
  • Cardiac Hemorrhaging
  • Cardiovascular Disease
  • Connective Tissue Disorders
  • Organismal Injury and Abnormalities
 Bleeding of pericardium 0.00926
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Lesioning of liver 0.0096
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Liver Steatosis
  • Metabolic Disease
  • Organ Deve
 Steatohepatitis 0.0111
  • IL6
  • PTEN
  • Decreased Levels of Albumin
  • Molecular Transport
 Decreased secretion of albumin 0.0127
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hyperplasia of hepatocytes 0.0127
  • PTEN
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Cell Morphology
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hypertrophy of heart cells 0.0128
  • Decreased Levels of Albumin
 Decreased synthesis of albumin 0.013
  • IL6
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Cell death of sinusoidal endothelial cells 0.0134
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Failure
  • Organismal Injury and Abnormalities
 Failure of liver 0.014
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Proliferation
  • Organ Development
  • Tissue Development
 Proliferation of hepatocytes 0.0152
  • IL6
  • PTEN
  • TP53
  • Immunological Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Autoimmune glomerulonephritis 0.0156
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Renal Proliferation
  • Renal and Urological System Development and Function
 Cell proliferation of kidney cell lines 0.0167
  • ESR1
  • IL6
  • TP53
  • Cellular Development
  • Cellular Growth and Proliferation
  • Renal Proliferation
  • Renal and Urological System Development and Function
 Arrest in growth of kidney cell lines 0.0178
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Cirrhosis
  • Organismal Injury and Abnormalities
 Cirrhosis of liver 0.0179
  • IL6
  • PCNA
  • TP53
  • Decreased Levels of Albumin
 Decreased activation of albumin 0.0198
  • TP53
  • Cardiovascular Disease
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Reperfusion injury of liver 0.0201
  • PTEN
  • Increased Levels of Alkaline Phosphatase
 Increased activation of alkaline phosphatase 0.0233
  • ESR1
  • IL6
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Inflammation of liver 0.0233
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Cardiac Proliferation
  • Cardiovascular System Development and Function
  • Cellular Development
  • Cellular Growth and Proliferation
  • Embryonic Development
  • Organ Development
  • Organismal Development
  • Skeletal and Muscular System Development and Function
  • Tissue
 Proliferation of cardiomyocytes 0.0268
  • IL6
  • PTEN
  • Increased Levels of ALT
 Increased release of ALT 0.0269
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Severe hepatic steatosis 0.0272
  • ESR1
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Cirrhosis
  • Organismal Injury and Abnormalities
 Compensated cirrhosis 0.0275
  • PCNA
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Hypertrophy of heart 0.0283
  • Lipid Metabolism
  • Liver Cholestasis
  • Molecular Transport
  • Small Molecule Biochemistry
 Secretion of bile acid 0.0295
  • ESR1
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Susceptibility to myocardial infarction 0.0295
  • ESR1
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 Cortical renal glomerulopathies 0.0305
  • ESR1
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Pyelonephritis 0.0366
  • IL6
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Myocardial infarction 0.0374
  • ELAVL1
  • ESR1
  • IL6
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 Glomerulonephritis 0.038
  • ESR1
  • IL6
  • TP53
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Organismal Injury and Abnormalities
 Congenital heart disease 0.0414
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • DNA Replication
  • Recombination
  • and Repair
  • Developmental Disorder
  • Endocrine System Disorders
  • Hereditary Disorder
  • Immunological Disease
  • Neurological Disease
  • Organismal Injury and Abnormalities
  • Skelet
 Shprintzen syndrome 0.0438
  • Biliary Hyperplasia
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organismal Development
  • Tissue Development
 Proliferation of cholangiocytes 0.0471
  • IL6
  • Glutathione Depletion In Liver
  • Liver Fibrosis
 Production of reactive oxygen species in liver 0.0475
  • PTEN
  • Cell Death and Survival
  • Cellular Development
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Regeneration
  • Organ Morphology
 Regeneration of liver cells 0.0475
  • IL6
  • Hepatic System Development and Function
  • Liver Proliferation
  • Organ Morphology
  • Tissue Morphology
 Quantity of hepatocytes 0.0537
  • TP53
  • Glutathione Depletion In Liver
 Quantity of glutathione in liver 0.0547
  • IL6
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Familial congenital heart disease 0.0554
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Necrosis of liver 0.0586
  • ESR1
  • IL6
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Steatosis
  • Metabolic Disease
  • Organismal Injury and Abnormalities
 Microvesicular hepatic steatosis 0.0599
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Growth of hepatocellular carcinoma 0.0602
  • IL6
  • Cardiac Dysfunction
  • Cardiac Fibrosis
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Fibrosis of left ventricle 0.0654
  • ELAVL1
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Damage of liver 0.0667
  • IL6
  • PTEN
  • TP53
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Cell Morphology
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
  • Skeletal and Muscular System Deve
 Hypertrophy of cardiomyocytes 0.0674
  • IL6
  • PTEN
  • Cardiac Dilation
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Idiopathic dilated cardiomyopathy 0.0705
  • IL6
  • Cardiac Enlargement
  • Cardiovascular Disease
  • Cardiovascular System Development and Function
  • Organ Morphology
  • Organismal Development
  • Organismal Injury and Abnormalities
 Right ventricular hypertrophy 0.0721
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Fibrosis
  • Organismal Injury and Abnormalities
 Fibrosis of liver 0.0724
  • IL6
  • TP53
  • Increased Levels of ALT
 Increased localization of ALT 0.0744
  • IL6
  • Glomerular Injury
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Abnormal morphology of mesangial matrix 0.0753
  • ESR1
  • Cardiac Dysfunction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Dysfunction of left ventricle 0.0779
  • ELAVL1
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatoblastoma 0.0788
  • TP53
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Apoptosis of hepatocytes 0.0876
  • IL6
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Inflammation/Hepatitis
  • Organ Development
  • Organismal Injury and Abnor
 Alcoholic hepatitis 0.088
  • IL6
  • Cardiac Necrosis/Cell Death
  • Cardiovascular System Development and Function
  • Cell Death and Survival
  • Skeletal and Muscular System Development and Function
 Cell viability of cardiomyocytes 0.088
  • PTEN
  • Cell Death and Survival
  • Glomerular Injury
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Apoptosis of podocytes 0.0893
  • TP53
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatocellular adenoma 0.0927
  • PTEN
  • Immunological Disease
  • Inflammatory Disease
  • Inflammatory Response
  • Organismal Injury and Abnormalities
  • Renal Inflammation
  • Renal Nephritis
  • Renal and Urological Disease
 IgA nephropathy 0.0937
  • TP53
  • Cardiac Necrosis/Cell Death
  • Cardiovascular Disease
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Apoptosis of ventricular myocytes 0.0996
  • TP53
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal and Urological Disease
 Damage of kidney 0.102
  • IL6
  • TP53
  • Cell Death and Survival
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Necrosis/Cell Death
  • Organismal Injury and Abnormalities
 Apoptosis of liver cell lines 0.104
  • TP53
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Infectious Diseases
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Damage
  • Liver Inflammation/Hepatitis
  • Organ Devel
 Chronic hepatitis B 0.107
  • IL6
  • Organ Morphology
  • Organismal Injury and Abnormalities
  • Renal Enlargement
  • Renal and Urological Disease
  • Renal and Urological System Development and Function
 Hypertrophy of renal glomerulus 0.109
  • ESR1
  • Cardiovascular Disease
  • Congenital Heart Anomaly
  • Developmental Disorder
  • Hereditary Disorder
  • Organismal Injury and Abnormalities
 Double outlet right ventricle 0.111
  • TP53
  • Cardiac Damage
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Cardiotoxicity 0.118
  • ESR1
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal Tubule Injury
  • Renal and Urological Disease
 Damage of renal tubule 0.119
  • TP53
  • Increased Levels of Creatinine
 Increased Levels of Creatinine 0.129
  • IL6
  • Cellular Development
  • Cellular Growth and Proliferation
  • Organ Development
  • Renal Proliferation
  • Renal and Urological System Development and Function
 Proliferation of mesangial cells 0.131
  • IL6
  • Cardiovascular System Development and Function
  • Cellular Development
  • Cellular Growth and Proliferation
  • Connective Tissue Development and Function
  • Digestive System Development and Function
  • Hepatic System Development and Function
  • Liver Fibrosis
  • Liver
Proliferation of hepatic stellate cells 0.145
  • IL6
  • Cell-To-Cell Signaling and Interaction
  • Connective Tissue Development and Function
  • Hepatic System Development and Function
  • Liver Fibrosis
 Activation of hepatic stellate cells 0.155
  • IL6
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Damage
  • Organismal Injury and Abnormalities
 Hepatic injury 0.176
  • IL6
  • PTEN
  • Digestive System Development and Function
  • Gastrointestinal Disease
  • Hepatic System Development and Function
  • Hepatic System Disease
  • Infectious Diseases
  • Inflammatory Disease
  • Inflammatory Response
  • Liver Damage
  • Liver Inflammation/Hepatitis
  • Organ Devel
 Chronic hepatitis C 0.185
  • IL6
  • Cell Death and Survival
  • Organismal Injury and Abnormalities
  • Renal Necrosis/Cell Death
  • Renal and Urological Disease
 Apoptosis of kidney cell lines 0.189
  • ESR1
  • TP53
  • Cardiac Arteriopathy
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
 Coronary artery disease 0.196
  • ESR1
  • IL6
  • Increased Levels of Hematocrit
 Increased Levels of Hematocrit 0.208
  • TP53
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Cholestasis
 Cholestasis 0.21
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Hepatocellular Carcinoma
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Hepatocellular carcinoma 0.221
  • ESR1
  • IL6
  • PTEN
  • TP53
  • Increased Levels of Red Blood Cells
 Increased Levels of Red Blood Cells 0.234
  • TP53
  • Cardiac Infarction
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Acute myocardial infarction 0.281
  • IL6
  • Cardiac Arrythmia
  • Cardiovascular Disease
  • Organismal Injury and Abnormalities
  • Skeletal and Muscular Disorders
 Atrial fibrillation 0.293
  • IL6
  • Cardiac Congestive Cardiac Failure
  • Cardiovascular Disease
  • Heart Failure
  • Organismal Injury and Abnormalities
 Congestive heart failure 0.309
  • IL6
  • Organismal Injury and Abnormalities
  • Renal Damage
  • Renal and Urological Disease
 Injury of kidney 0.323
  • IL6
  • Kidney Failure
  • Organismal Injury and Abnormalities
  • Renal and Urological Disease
 End stage renal disease 0.331
  • IL6
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver carcinoma 1.0
  • COPA
  • ELAVL1
  • ESR1
  • GPR32
  • IL6
  • NEIL1
  • PTEN
  • TMEM127
  • TP53
  • TRIM25
  • Cancer
  • Gastrointestinal Disease
  • Hepatic System Disease
  • Liver Hyperplasia/Hyperproliferation
  • Organismal Injury and Abnormalities
 Liver tumor 1.0
  • CDC14B
  • COPA
  • ELAVL1
  • ESR1
  • FAM105A
  • FAM131A
  • GPR32
  • GPR87
  • HTR2C
  • IL6
  • NEIL1
  • PCNA
  • PHTF2
  • PTEN
  • QRFPR
  • TMEM127
  • TP53
  • TRIM25