Gene: ADGRA2;
Trait | Type | #Publications | #Studies | #Associations | Correlations | CpG Island |
|---|---|---|---|---|---|---|
| acute myelocytic leukemia (AML) | cancer | 2 | 5 | 2579 | Hyper: 1%; Hypo: 99%; NR: 0% | cpg: 28%; shore: 27%; shelf: 11%; other: 33% |
| aging | phenotype | 30 | 33 | 46883 | Hyper: 54%; Hypo: 41%; NR: 6% | cpg: 26%; shore: 26%; shelf: 11%; other: 38% |
| air pollution (NO2) | environmental factor | 4 | 4 | 5272 | Hyper: 67%; Hypo: 33%; NR: 0% | cpg: 7%; shore: 21%; shelf: 19%; other: 53% |
| air pollution (PM2.5) | environmental factor | 9 | 11 | 3977 | Hyper: 52%; Hypo: 48%; NR: 0% | cpg: 27%; shore: 24%; shelf: 16%; other: 33% |
| autism spectrum disorders (ASD) | non-cancer disease | 6 | 6 | 869 | Hyper: 23%; Hypo: 76%; NR: 1% | cpg: 15%; shore: 19%; shelf: 18%; other: 49% |
| B Acute Lymphoblastic Leukemia with dic(9;20)(p11;q13) | cancer | 1 | 1 | 2379 | Hyper: 36%; Hypo: 64%; NR: 0% | cpg: 34%; shore: 26%; shelf: 10%; other: 29% |
| B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1 | cancer | 2 | 2 | 4791 | Hyper: 32%; Hypo: 68%; NR: 0% | cpg: 21%; shore: 23%; shelf: 13%; other: 42% |
| B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) | cancer | 1 | 1 | 21099 | Hyper: 85%; Hypo: 15%; NR: 0% | cpg: 50%; shore: 24%; shelf: 12%; other: 14% |
| breast cancer | cancer | 13 | 13 | 3605 | Hyper: 35%; Hypo: 64%; NR: 1% | cpg: 31%; shore: 25%; shelf: 13%; other: 31% |
| child abuse | environmental factor | 4 | 4 | 2924 | Hyper: 59%; Hypo: 41%; NR: 0% | cpg: 57%; shore: 18%; shelf: 9%; other: 16% |
Probe ID | Studies | Correlations | Location | Related genes (transcript: location) | CpG islands | Related traits |
|---|---|---|---|---|---|---|
| cg13726789 | 9 | Hyper: 22%;Hypo: 44%;NR: 33% | chr8: 37678323 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Other | |
| cg18715243 | 9 | Hyper: 11%;Hypo: 89%;NR: 0% | chr8: 37658755 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Shelf | |
| cg07118000 | 7 | Hyper: 57%;Hypo: 43%;NR: 0% | chr8: 37656246 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: promoter); | Shore | |
| cg05552035 | 5 | Hyper: 40%;Hypo: 60%;NR: 0% | chr8: 37699239 | ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Island | |
| cg09121695 | 5 | Hyper: 100%;Hypo: 0%;NR: 0% | chr8: 37655503 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: promoter); ADGRA2 (ENST00000412232: promoter); | Island | |
| cg20272648 | 4 | Hyper: 0%;Hypo: 100%;NR: 0% | chr8: 37660108 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Other | |
| cg01751917 | 4 | Hyper: 25%;Hypo: 50%;NR: 25% | chr8: 37658571 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Shelf | |
| cg14930065 | 3 | Hyper: 100%;Hypo: 0%;NR: 0% | chr8: 37672607 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Other | |
| cg20011352 | 3 | Hyper: 100%;Hypo: 0%;NR: 0% | chr8: 37655269 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: promoter); ADGRA2 (ENST00000412232: promoter); | Island | |
| cg23649140 | 3 | Hyper: 67%;Hypo: 33%;NR: 0% | chr8: 37661612 | ADGRA2 (ENST00000428068: body); ADGRA2 (ENST00000315215: body); ADGRA2 (ENST00000412232: body); | Other |
Gene ID | Location | Expression | #Association | Promoter/Body | Correlations | #Related Traits | Most Related traits (#Associations) |
|---|---|---|---|---|---|---|---|
| ADGRA2; ENSG00000020181 | (+) chr8:37641709-37702414 | 78 | body: 99%; promoter: 1% | Hyper: 50%; Hypo: 42%; NR: 8% | 45 |
PMID | Title | Year | Journal | Citation | Datasets |
|---|---|---|---|---|---|
| 24287154 | Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer. | 2014 | Carcinogenesis | 53 | GSE19711 GSE20067 |
| 27651444 | Epigenetic Signatures of Cigarette Smoking. | 2016 | Circ Cardiovasc Genet | 123 | |
| 23332324 | Child abuse and epigenetic mechanisms of disease risk. | 2013 | Am J Prev Med | 70 | |
| 27040690 | DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. | 2016 | Am J Hum Genet | 173 | GSE33828 |
| 28428831 | Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns. | 2017 | Clin Epigenetics | 3 | |
| 27404287 | Genetic and epigenetic methylation defects and implication of the ERMN gene in autism spectrum disorders. | 2016 | Transl Psychiatry | 4 | GSE40279 |
| 27417303 | Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy. | 2016 | Genomics | 5 | GSE81339 |
| 26999364 | Whole-Genome Saliva and Blood DNA Methylation Profiling in Individuals with a Respiratory Allergy. | 2016 | PLoS One | 13 | GSE73745 |
| 24603685 | Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. | 2014 | PLoS Genet | 161 | |
| 26237075 | Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia. | 2015 | Epigenetics | 8 | GSE69229 |